Assessment of punctal metrics and tear meniscus height in epiphora: clinical insights and diagnostic potential.

Purpose: To use anterior segment optical coherence tomography (AS-OCT) to investigate differences in punctal dimensions, tear meniscus height (TMH), and cornea among epiphora patients and healthy individuals; to assess its utility in screening and diagnosing epiphora; and to examine its effects on the cornea.

Study Design: Prospective, cross-sectional METHODS: A total of 43 patients (31 women) with epiphora (Munk score >2) and 58 healthy individuals (38 women) without ocular symptoms were enrolled in this study. AS-OCT (Maestro, Topcon) was used to measure TMH, outer punctal diameter (OPD), punctal depth (PD), and corneal epithelial thickness (CET).

Do positional and non-positional obstructive sleep apnoea differ clinically? A further comparison of supine-isolated and supine-predominant subgroups.

Introduction: Obstructive Sleep Apnoea (OSA) is a heterogeneous disorder characterized by recurrent upper airway obstructions during sleep. Positional OSA (POSA) and non-positional OSA are major subgroups that differ in clinical, polysomnographic, and treatment aspects. Furthermore, POSA can be classified into supine-isolated POSA (siPOSA) and supine-predominant POSA (spPOSA), which exhibit distinct characteristics.

Association of maternal calprotectin plasma levels with abruption placenta.

Objective: The aim of this study was to investigate the relationship between placental abruption and maternal plasma calprotectin levels.

Materials And Methods: This prospective study included 3865 pregnant women aged 24 weeks' gestation and older who were admitted to Etlik Zübeyde Hanım Women's Health Training and Research Hospital between January 2021 and January 2024. Calprotectin levels were prospectively studied in 33 pregnant women with placental abruption and compared with 48 healthy pregnant women matched for age, parity, body mass index (BMI) and week of gestation.

End-of-life decision disparities according to the gross national income in critically ill patients: a secondary analysis of the ETHICUS-2 study.

Aim: This study aimed to evaluate the association of end-of-life decisions and time to death in a global cohort of critically ill patients who participated in the international study on end-of-life practices in intensive care units (ICU) (Ethicus-2 study).

Methods: A post hoc analysis was conducted on data from a worldwide observational study that prospectively recruited adult ICU patients who died between September 1, 2015, and September 30, 2016, from 199 ICUs in 36 countries.

Results: The end-of-life pathways of 10,547 ICU non-survivors were s analysed.

Impact of Growth Hormone Co-Treatment in Patients with Diminished Ovarian Reserve on In-Vitro Fertilisation Outcomes.

Objective: To assess the efficacy of growth hormone (GH) co-treatment during controlled ovarian stimulation for in-vitro fertilisation (IVF).

Study Design: Descriptive analytical. Place and Duration of the Study: Department of Gynaecology, Etlik Zubeyde Hanim Training and Research Hospital, Ankara, Turkiye, from January 2010 to 2023.

Post-Transcatheter Aortic Valve Implantation QRS Interval Alternans: What Is the Mechanism?

Alternating bundle branch block is a significant conduction abnormality observed after transcatheter aortic valve replacement. This electrocardiographic finding indicates progressive conduction system disease, often on a background of preexisting conduction disturbances (eg, right bundle branch block). However, the presence of alternating fascicular block is very rare.

Repeat Microvascular Decompression for Recurrent Trigeminal Neuralgia.

Introduction: Trigeminal neuralgia (TN) is described as the most excruciating pain typically involving the face. Microvascular decompression (MVD) is regarded as the established method of treatment of the condition. We aimed to detect the underlying pathology in recurrent TN cases, to prevent the recurrence rate of the patients and to determine the difficulties encountered during surgery.

Colon Cancer Screening, Surveillance, and Treatment: Novel AI driving strategies in the management of colon lesions.

Colonoscopy, a crucial procedure for detecting and removing colorectal polyps, has seen transformative advancements through the integration of Artificial Intelligence (AI), specifically in Computer-Aided Detection (CADe) and Diagnosis (CADx). These tools enhance real-time detection and characterization of lesions, potentially reducing human error, and standardizing the quality of colonoscopy across endoscopists. CADe has proven effective in increasing adenoma detection rate, potentially reducing long-term colorectal cancer incidence.

Multimodal Imaging for Evaluation and Quantification of Atrophy Progression in Extensive Macular Atrophy with Pseudodrusen.

Aim: To present the atrophy progression rate with fundus autofluorescence (FAF) and optical coherence tomography (OCT) findings in patients with extensive macular atrophy with a pseudodrusen-like appearance.

Methods: Eight patients who were followed up with the diagnosis of diffuse macular atrophy accompanied by pseudodrusen were included. Medical records, FAF, and OCT images at consecutive follow-ups were reviewed.

Metal hypersensitivity after Nuss procedure: What and when to do?

Background: Metal hypersensitivity after Nuss procedure is a known complication, but there is no accepted treatment guideline available.

Methods: Patients undergoing Nuss procedure between 2013-2023 were examined retrospectively. Patients with known allergy, positive blood and/or culture tests, and re-do cases were excluded.

Ovarian Hyperstimulation secondary to clomiphene citrate resulting in ovarian torsion: A rare report.

Introduction: Ovarian hyperstimulation syndrome (OHSS) is a potentially severe complication of ovulation induction. Although less common than with gonadotropin treatment, OHSS can occur secondary to an excessive dose of clomiphene citrate, a first-line ovulation induction agent. A serious complication of OHSS is ovarian torsion, which demands prompt diagnosis and intervention to prevent permanent damage.

Outcomes after pancreatoduodenectomy and total pancreatectomy in patients with a high-risk pancreatic anastomosis: An entropy balance analysis.

Background: The benefit of performing a total pancreatectomy in high-risk patients is largely debated. Our aim is to evaluate what would have been the short-term outcomes of patients who underwent a high-risk pancreatoduodenectomy if a total pancreatectomy was performed instead.

Methods: Perioperative data from patients who underwent pancreatoduodenectomy or total pancreatectomy at 5 tertiary hepato-pancreato-biliary centers (2016-2022) were collected prospectively.

Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium.

Purpose: Clinical and histopathologic diagnosis of pediatric mature B-cell lymphomas (eg, Burkitt lymphoma [BL]) must be accurate to select appropriate risk-based treatment. The Central American Pediatric Hematology-Oncology Association (AHOPCA) in 2000 implemented standardized, resource-adapted treatments for these lymphomas. We evaluated the concordance of local histopathologic diagnoses through central review, determined the impact on therapy selection, and described the clinical characteristics and outcomes of pediatric patients with these lymphomas.

Evaluation of drug-related anaphylaxis in children: multi-center study.

The aim of the study is to elucidate demographic characteristics, risk factors, clinical presentations, causative agents, and management approaches pertaining to drug-related anaphylaxis in the paediatric population. This study is a multicenter retrospective study that included paediatric patients aged between 1 month and 18 years, who were admitted to the Pediatric Allergy and Immunology outpatient clinics of 11 participating centres with a presumptive diagnosis of drug-induced anaphylaxis, that fulfilled the standardised criteria for anaphylaxis, between January 2017 and December 2022. A total of 293 anaphylactic episodes presented among 265 patients, of which 48.

Predictive factors of mortality in patients with abdominal trauma.

Background: Traumatic injuries, particularly abdominal trauma, are a major cause of mortality worldwide. This study aimed to evaluate predictive factors for mortality and morbidity in abdominal trauma patients using simple, rapid, and accessible clinical and laboratory parameters, with a focus on developing scoring systems for emergency department decision-making.

Methods: A retrospective cohort study was conducted in a Level 1 Trauma Center between October 2022 and March 2024.

The effect of nicardipine on the zone of stasis in burns: An experimental rat model.

Background: The zone of stasis in burns is particularly vulnerable to progressive ischemia, making it a critical target for therapeutic interventions. Preventing damage in this zone is essential, as its viability can be preserved with adequate perfusion. Recognizing this, we aimed to investigate the systemic effects of nicardipine, a calcium channel blocker with vasodilatory properties, on the stasis zone in an experimentally induced burn model in rats.

The effect of clinical, bifurcation, and aneurysm morphological characteristics on the risk of rupture in internal carotid artery bifurcation aneurysms.

Background: This study aimed to examine the clinical and morphological characteristics associated with the risk of rupture of internal carotid artery (ICA) bifurcation aneurysms (ICAbifAn) by comparing ruptured and unruptured aneurysms.

Methods: The two-center observational study included 66 patients with ICAbifAn (4.3%) identified from a database of 1,512 patients with intracranial aneurysms.

The utilization of serum thrombopoietin levels as an early biomarker in determining severe acute biliary pancreatitis.

Background: This study aimed to evaluate the efficacy of thrombopoietin (TPO), a growth factor and acute-phase reactant, as an early prognostic marker for predicting disease severity in patients with acute biliary pancreatitis.

Methods: A total of 72 patients with acute pancreatitis admitted to the Ankara Numune Training and Research Hospital, General Surgery Department, were included in the study. The severity of acute pancreatitis was classified using the 2012 Revised Atlanta Classification, and blood samples were collected from each patient within the first six hours of hospitalization to measure TPO levels.

ChatGPT's competence in responding to urological emergencies.

Background: In recent years, artificial intelligence (AI) applications have been increasingly used as sources of medical information, alongside their applications in many other fields. This study is the first to evaluate ChatGPT's performance in addressing urological emergencies (UE).

Methods: The study included frequently asked questions (FAQs) by the public regarding UE, as well as UE-related questions formulated based on the European Association of Urology (EAU) guidelines.

Hepatoerythropoietic Porphyria with Coexisting And Genetic Mutations: A First Case Report.

Introduction: Hepatoerythropoietic porphyria (HEP) is an uncommon autosomal recessive disorder marked by deficiencies in enzymes involved in heme biosynthesis. This results in the build-up of porphyrins and their precursors. Here, we describe a case study of a 17-year-old male who has experienced symptoms of porphyria since early childhood.