Development of a sample preparation and analysis method for therapeutic monitoring of diazepam and major metabolite in alcohol withdrawal syndrome treatment.

Diazepam, a widely prescribed benzodiazepine, is frequently used for the management of alcohol withdrawal syndrome, anxiety, seizures, and muscle spasms. Its monitoring is critical due to its potential for abuse and the therapeutic importance of its metabolite nordiazepam. A sustainable and environmentally friendly high-performance liquid chromatography method was developed and validated for the quantification of diazepam and its active metabolite nordiazepam in human plasma samples.

Prevalence and incidence of neuromyelitis optica spectrum disorder in Türkiye: A nationwide epidemiologic study.

Background: Epidemiological studies of neuromyelitis optica spectrum disorder (NMOSD) show variability due to differences in methodologies, diagnostic criteria, and geographic factors.

Objective: This study aimed to determine NMOSD's epidemiological profile in Türkiye using official health records covering over 95 % of the population.

Methods: Data were collected using ICD-10 codes (G36.

The Effect of Music Recital on Labor Anxiety and Satisfaction: A Randomized Controlled Study.

Background: Music as a distraction is used in various areas of obstetrics and gynecology to reduce fear, pain and anxiety.

Objective: In this study, it was aimed to determine the effect of music recital on labor anxiety and satisfaction.

Methods: The study was conducted in a hospital between June 12 and November 30, 2019.

Demographic analysis of patients requiring ophthalmology consultation in the emergency department: A retrospective study at a tertiary care center.

This study aims to determine the necessary preventive measures from the perspective of primary care by examining the demographic characteristics and initial diagnoses of patients who were evaluated by an ophthalmologist following an emergency consultation request. Individuals over the age of 18 who had complete data and were referred for ophthalmic consultation from the emergency department within in 2022 were included in the study. The study retrospectively reviewed the patients' age, gender, diagnoses, status of ophthalmic consultation, whether a forensic report was prepared, and the outcomes of follow-up, hospitalization, or discharge.

Epidural volume extension versus dural puncture epidural analgesia for labor: A prospective randomized study.

Background: Providing effective labor analgesia is very important for maternal and infant safety. Various neuraxial techniques are used for this purpose. Our objective was to compare the epidural volume extension (EVE) and dural puncture epidural (DPE) procedures employed in clinical practice for labor analgesia, focusing on labor parameters, pain levels, fetal outcomes, and complications.

Development of the Dentofacial Appearance Perception Scale: Validity and reliability study.

Concerns about the appearance of teeth and mouth, which play a key role in communication and first impressions, are natural to some extent. However, excessive concern over these areas should raise suspicion of body dysmorphic disorder (BDD). The use of a validated and standardized screening tool in dental settings may improve the identification of BDD.

Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.

Regulation of mitochondrial Ca uptake is critical in cardiac adaptation to chronic stressors. Abnormalities in Ca handling, including mitochondrial uptake mechanisms, have been implicated in pathological heart hypertrophy. Enhancing mitochondrial Ca uniporter (MCU) expression has been suggested to interfere with maladaptive development of heart failure.

A systematic review and meta-analysis of the effectiveness of remdesivir to treat SARS-CoV-2 infection in hospitalized patients: have the guidelines evolved with the evidence?

Background: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir (RDV), a broad-spectrum antiviral. Given the evolving nature of COVID-19, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review (SLR) with meta-analysis (MA) to summarize RDV effectiveness among hospitalized adults.

Head-to-Head comparison of [F]FES and [F]FDG PET/CT in breast cancer patients: has a new era come?

Purpose: This review systematically compared, in a head-to-head manner, the diagnostic and prognostic performance of [F]FDG and [F]FES PET/CT in breast cancer (BC) patients.

Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science databases up to January 2025, without temporal limitations or restrictions on the number of patients in the included studies, to identify relevant articles comparing the diagnostic value of [F]FDG and [F]FES PET in BC patients. Selected imaging studies were analyzed using a modified version of the Critical Appraisal Skills Programme checklist dedicated to systematic reviews.

Expanding horizons: the feasibility and challenges of tubular retraction in endoscopic transorbital skull base approaches.

Purpose: Endoscopic transorbital skull base approaches are always challenging and require good anatomical knowledge.The aim of this study was to describe the anatomical pathways of endoscopic transorbital approaches and to determine the limitations of these procedures. To evaluate the feasibility of the tubular retractor and the difference with manual retractor.

Preoperative hemoglobin A1c as a predictor of lymph node metastasis in diabetic women with endometrial cancer.

Background: Glycated hemoglobin A1c (HbA1c) is a well-established marker for glycemic control; recent studies suggest its potential role in cancer prognosis. Understanding the relationship between preoperative HbA1c levels and lymph node metastasis (LNM) in diabetic women with endometrial cancer (EC) can enhance prognostic assessments and treatment strategies.

Objectives: This study aimed to evaluate the predictive value of preoperative HbA1c levels for LNM in diabetic women with EC.

Utility of Median Nerve Electrophysiological Parameters in Differentiating Immune-Mediated Demyelination From Compressive Median Neuropathy at the Wrist.

Introduction/aims: Prolonged distal median motor latency (DML) may occur in carpal tunnel syndrome (CTS), potentially causing an electrodiagnostic dilemma in acquired demyelinating polyneuropathies. We aimed to demonstrate that parameter values obtained from conventional median nerve conduction studies can distinguish immune-mediated demyelination from compression-induced damage.

Methods: We retrospectively reviewed the median nerve records of 73 control individuals, 125 patients with pure CTS, 31 with CTS and diabetic distal symmetric polyneuropathy, 36 with acute inflammatory demyelinating polyneuropathy, and 23 with chronic inflammatory demyelinating polyneuropathy.

The enigma of familial Mediterranean fever: phenotypic characterization of patients harboring variants of uncertain significance.

Objective: To assess the phenotypic characteristics of the patients carrying variants of uncertain significance (VUS) in the Mediterranean fever (MEFV) gene.

Methods: The study included patients carrying only VUS in the MEFV gene. Patients were excluded if they did not meet the pediatric criteria for familial Mediterranean fever (FMF).

Influence of Child-Level Factors and Lexical Characteristics on Vocabulary Knowledge of Children With Cochlear Implants and Hearing Aids.

Recent studies indicate children who are deaf and hard of hearing who use cochlear implants or hearing aids know fewer spoken words than their peers with typical hearing, and often those vocabularies differ in composition. To date, however, the interaction of a child's auditory profile with the lexical characteristics of words he or she knows has been minimally explored. The purpose of the present study is to evaluate how audiological history, phonological memory, and overall vocabulary knowledge interact with growth in types of spoken words known by children who are deaf and hard of hearing compared to children with typical hearing.

RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression.

Despite well-documented metabolic and hematopoietic alterations during tumor development, the mechanisms underlying this crucial immunometabolic intersection remain elusive. Of particular interest is the connection between lipid metabolism and the retinoic-acid-related orphan receptor (RORC1/RORγ), whose transcriptional activity modulates cancer-related emergency myelopoiesis and is boosted by cholesterol metabolites, while hypercholesterolemia itself is associated with dysregulated myelopoiesis. Here, we show that cancer and hypercholesterolemic diet independently or cooperatively activate RORγ-dependent expansion of myeloid-derived suppressor cells (MDSCs) and M2-polarized tumor-associated macrophages (TAMs), supporting cancer spread.

Effects of immersive virtual reality-based action observation training integrated with focal muscle vibration on upper extremity in a patient with chronic disability following stroke: a single-subject study.

Background: The association of different sensory inputs enhances brain plasticity in patients after stroke, but no studies have associated Action Observation Training (AOT) delivered in immersive virtual reality (VR) with Focal Vibration (FV) to elicit a kinesthetic illusion coherent with the observed task to improve motor function.

Objective: The study aimed to evaluate the feasibility of AOT delivered in immersive VR integrated with FV of upper limb muscles on manual dexterity in patients with chronic stroke.

Methods: A single-subject study was conducted (A-B design).

Socioeconomic Disparities in Prostate Cancer Treatment: The Impact of Area Deprivation Index on Initial Treatment Type for Localized PCa in a North-American Cohort.

Background: Socioeconomic status and geographical location contribute to disparities in localized prostate cancer (PCa) treatment. We examined the impact of area of deprivation index (ADI) on initial treatment type for localized PCa in a North-American cohort.

Methods: We performed a retrospective analysis of patients diagnosed with localized PCa, treated within Henry Ford Health (HFH), between 1995 and 2022, with available ADI-data.

Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis.

Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.

Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.

Impact of prostate cancer screening in European ancestry un-affected men with germline DNA repair pathogenic variants.

Background And Objective: Prostate cancer (PCa) is a significant global health concern, ranking as the second most prevalent cancer among men worldwide. Genetic factors, particularly germline pathogenic variants (PVs) in DNA repair genes (DRGs), play a crucial role in PCa predisposition. Our study aimed to assess patients' adherence to a targeted PCa screening program targeting high-risk individuals with DRG PVs and evaluate the potential reduction in biopsy and MRI rates by employing our screening protocol.

Do The Inflammatory Cells In The Blood And Tissues Have Predictive And Prognostic Value In Benign, Premalignant And Malignant Lesions Of The Larynx?

Objective: The aim of our study is to investigate the predictive and prognostic value of inflammatory cells in blood and tissues in laryngeal lesions.

Methods: The data of a total of 112 patients, of whom 36 had benign, 38 had premalignant and 38 had malignant laryngeal lesions, were analyzed retrospectively. Along with the demographic characteristics of the patients, hemogram parameters were also captured by hematoxylin-eosin staining performed on pathology preparation lymphocytes and neutrophils, and Langerhans cells count was carried out by immunohistochemical staining.

Long-Term Efficacy and Quality-of-Life Changes After Vagus Nerve Stimulation in Adult Patients With Drug-Resistant Epilepsy.

Background And Purpose: There is a current need to understand the efficacy and quality of life (QoL) outcomes of vagus nerve stimulation (VNS). Identifying patients most likely to benefit from VNS could aid in their selection, reduce side effects, and improve outcomes. Here we studied clinical and QoL outcomes after VNS in patients with drug-resistant epilepsy and attempted to identify response predictors.

A retrospective comparative analysis of anterior cervical discectomy and fusion using stand-alone titanium cage versus cage and plate fixation in two-level cervical disc herniation.

Background: This study aims to compare the outcomes of two-level anterior cervical discectomy and fusion (ACDF) procedures using stand-alone cages versus cage and plate fixation in patients diagnosed with cervical disc herniation (CDH).

Materials And Methods: This retrospective analysis included 60 patients who underwent two-level ACDF procedures. Patients were divided into two groups: one treated with stand-alone cages and the other with cage and plate fixation.

Health-related quality of life after radical cystectomy for bladder cancer in elderly patients with ileal orthotopic neobladder, ureterocutaneostomy or ileal conduit: cross-sectional study using validated questionnaires.

Purpose: The most appropriate form of urinary diversion (UD) after radical cystectomy remains controversial. In this study, we aimed to compare the health-related quality of life questionnaire results of patients who underwent orthotopic neobladder (ONB), ureterocutaneostomy (UC) and ileal conduit (IC) diversion.

Materials: A total of 92 patients, including 42 out of 65 IC patients, 11 out of 15 ONB patients, and 39 out of 59 UC patients, completed the SF-36 and Barthel index quality of life questionnaires.