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Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer's disease.
Alzheimers Res Ther
November 2022
Unitat Trastorns Cognitius, Clinical Neuroscience Research, IRBLleida-Santa Maria Lleida University Hospital, Rovira Roure n° 44, 25198, Lleida, Spain.
Article Synopsis
- Obstructive sleep apnea (OSA) is common in Alzheimer’s disease (AD) patients and both conditions may affect lipid metabolism, prompting an investigation into lipid differences between AD patients with and without severe OSA.
- The study involved 103 AD patients, assessed for severe OSA via polysomnography and their blood lipid profiles analyzed with advanced techniques.
- A specific 4-lipid signature was found that accurately detected severe OSA, enhancing existing screening methods and suggesting a new approach for personalized patient management.