Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway.

Chronic kidney disease (CKD) is a conceivable new risk factor for cognitive disorder and dementia. Uremic toxicity, oxidative stress, and peripheral-central inflammation have been considered important mediators of CKD-induced nervous disorders. Nitric oxide (NO) is a retrograde neurotransmitter in synapses, and has vital roles in intracellular signaling in neurons.

Enhanced hemocompatibility, antimicrobial and anti-inflammatory properties of biomolecules stabilized AgNPs with cytotoxic effects on cancer cells.

In the current research, we developed a safe method using Iranian yarrow extract for the synthesis of silver nanoparticles (IY-AgNPs) as reducing and stabilizing agents in different conditions. The prepared and stabilized IY-AgNPs under optimal conditions were characterized using FT-IR, XRD, TEM, and UV-vis techniques. Also, the blood-clotting, hemolytic, antioxidant, bactericidal and, fungicidal properties, cytotoxicity effects and inhibition of protein denaturation efficiency of IY-AgNPs were assessed in vitro.

Structural, magnetic, and optical characteristics of undoped and chromium, iron, cobalt, copper, and zinc doped nickel oxide nanopowders.

The present investigation seeks to customize the optical, magnetic, and structural characteristics of nickel oxide (NiO) nanopowders through chromium, iron, cobalt, copper, and zinc doping to enhance optoelectronic applications. In this regard, the preparation of pristine NiO and Ni × O (X = Cr, Fe, Co, Cu, and Zn) powders was successfully achieved through the co-precipitation method. The X-ray powder diffraction was employed to examine the prepared powders' phase formation and crystal structure characteristics.

Impact of bariatric surgery on liver fibrosis indices among type 2 diabetes patients in a national cohort.

Obesity is related to liver fibrosis, a condition marked by the collection of scar tissue in the liver due to the development of a profibrotic environment, which includes increased hepatocellular death and elevated reactive oxygen species production. The aim of study is to evaluate the effect of bariatric surgery on the association between liver fibrosis indices and obesity. This is a retrospective cohort, evaluating 1205 individuals diagnosed with type 2 diabetes (T2D) and living with obesity, who experienced bariatric surgery.

Numerical simulation and experimental validation of the oleogel formation from grape seed oil and beeswax.

This study focuses on numerical modeling of the oleogelation process using grape seed oil and beeswax and its validation using experimental approach. The main goal is to investigate how the cooling rate affects this process. The necessary physical and thermal properties of the oleogel for modeling were determined through experiments.

Enhancing chickpea yield through the application of sulfur and sulfur-oxidizing bacteria.

Plant growth-promoting microorganisms can enhance sulfur uptake and boost crop production. This study was conducted to evaluate the changes in physiology, metabolism, and yield of chickpeas following the application of sulfur and two microbial consortia: (1) Thiobacillus sp., Bacillus subtilis, Paraburkholderia fungorum, and Paenibacillus sp.

Genomic evidence of improved fertility and adaptation in Iranian domestic sheep attributed to introgression from Asiatic Mouflon and urial.

Due to the diverse climate in Iran, there has been an opportunity for the emergence of different domestic sheep breeds. On the other hand, two of the seven wild sheep species have settled in the broad areas of Iran. This study investigated the introgression between wild and domestic Iranian sheep using the whole genome sequencing data for 55 domestic and 19 wild sheep.

Resilience and social isolation in people living with HIV: a case study in Iran.

Objective: People living with HIV (PLHIV) often face increased vulnerability due to factors like social isolation and reduced resilience. These factors can negatively impact health outcomes, quality of life, and well-being for both PLHIV and their families. Therefore, healthcare providers should carefully assess these variables when providing care for PLHIV.

Factors associated with hospital length of stay in patients with thoracic hydatid cyst disease undergoing surgical intervention: a retrospective study.

Background: Hydatid cyst (HC) frequently affects the lungs, making it the second most common site after the liver. This study evaluated the clinical characteristics, surgical procedures, complications, laboratory findings, and factors influencing hospital length of stay (LOS) in patients undergoing surgery for pulmonary hydatid cysts.

Methods: This retrospective observational study included adult patients who underwent surgery for lung HC between 2017 and 2021.

Academic burnout and its related factors among dental students in southeast Iran: a cross-sectional study.

Background And Aim: Academic burnout in students manifests as emotional exhaustion, depersonalization, and a sense of stagnation in their education. Given the high prevalence of occupational burnout among dental students, screening dental students for early signs of burnout can facilitate intervention and prevent negative effects on their physical and mental well-being.

Methods And Materials: This cross-sectional study included 180 clinical dentistry students in their third year and above at Kerman Dental Faculty during the academic year 2022-2023.

Tele-rehabilitation for children with physical disabilities: qualitative exploration of challenges in Iran.

Background: Children with physical disabilities (Having this type of disability can be due to any of the reasons such as cerebral palsy, genetic, developmental, neurodevelopment and any other reasons that cause physical disability in the child) need rehabilitation services. Tele-rehabilitation is a practical approach to provide rehabilitation services for children with rapid and continuous access. This approach has been used more recently and overcomes the limitations of conventional rehabilitation, which involves wasting time, traveling distance, and cost.

Natural products in the treatment of diabetic foot infection.

Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy of conventional treatments, highlighting the need for alternative therapeutic strategies. Natural products, known for their antimicrobial, anti-inflammatory, and wound-healing properties, have garnered attention as potential treatments for DFIs.

The effects of kefir drink on liver aminotransferases and metabolic indicators in patients with nonalcoholic fatty liver disease: a randomized controlled trial.

Background And Aim: Probiotics play an important role in the control and treatment of non-alcoholic fatty liver disease (NAFLD). Kefir drink is a fermented beverage and has indicated some beneficial health effects. The aim of this study was to evaluate the effects of kefir drink on liver aminotransferases, anthropometric indices, glycemic index, lipid profile, blood pressure (BP), high sensitivity C-reactive protein, and malondialdehyde in patients with NAFLD.

Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model.

Background: Inflammatory bowel disease (IBD) is a persistent inflammation of the digestive system, and Mesenchymal Stem Cells (MSCs) and their exosomes have demonstrated potential as treatments for this condition. The objective of this research was to examine the possible effectiveness of intraperitoneal injection of umbilical cord-MSCs (UC-MSCs) and their exosomes through a two-time injection regimen in a mouse model.

Method: In this study, an animal model of a specific type of IBD in C57BL/6 mice, induced by dextran sulfate sodium (DSS), was utilized.

Animal and bird-related ocular trauma: a decade of experience from a tertiary referral eye hospital of Iran.

Background: This study aimed to explore ocular and periocular injuries resulting from animal and bird attacks among patients referred to a tertiary referral eye hospital of Iran over ten years (2014-2024).

Methods: In this retrospective analysis, we collected data on patient demographics, the species of the attacking animal and bird, the nature of the ocular and periocular injuries, details of ophthalmological examinations, therapeutic interventions, and surgical treatments.

Results: One hundred and twenty-nine patients, with an average age of 36 ± 23 years (range: 1-77 years), were included in this study, of whom 81 were male.

The relationship between professional autonomy and job performance among Iranian ICU nurses: the mediating effect of job satisfaction and organizational commitment.

Background: Although previous studies have linked professional autonomy to nurses' job performance, research lacks how job satisfaction and organizational commitment mediate this relationship. Addressing this gap is essential for improving nursing practice outcomes. This study aims to determine the mediating effect of job satisfaction and organizational commitment in this relationship among Iranian nurses.

Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies.

Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist of lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. Exosomes play a critical role in the diagnosis and treatment of various diseases.

Shared decision-making in type 2 diabetes: a systematic review of patients' preferences and healthcare providers' perspectives.

Background: Shared decision-making (SDM) is crucial for type 2 diabetes mellitus (T2DM) management due to the complexity of treatment options. This systematic review sought to understand T2DM patients' preferences and diabetes care providers' perspectives regarding SDM, and the barriers and facilitators to SDM.

Methods: Five databases were searched from 2000 to 2023 (Medline/PubMed, Web of Science, Scopus, PsycINFO, and Embase).

Efficacy of two radiographic algorithms for detection of peri-implant bone defects on cone-beam computed tomography scans.

Background: Early detection of peri-implant bone defects can improve long-term durability of dental implants. By the advances in cone-beam computed tomography (CBCT) scanners and introduction of new algorithms, it is important to find the most efficient protocol for detection of bone defects. This study aimed to assess the efficacy of metal artifact reduction (MAR) and advanced noise reduction (ANR) algorithms for detection of peri-implant bone defects.

Facilitators and Barriers to adherence to antiretroviral therapy among incarcerated people living with HIV in Iran: insights from a qualitative study.

Background: Ensuring consistent adherence to antiretroviral therapy (ART) is crucial for effective HIV treatment and achieving viral suppression. Within prisons, the prevalence of HIV is notably high, and incarcerated individuals face an increased risk of transmitting the virus both during and after incarceration. However, facilitators and barriers to ART adherence among these individuals in low- and middle-income countries remain inadequately explored.

Pursuing a target by wheel-legged mobile robot using NMPC while optimizing obstacles passing.

In this paper, trajectory tracking control as the pursuit of a specific target by wheel-legged mobile robots (WLMRs) in an environment with the presence of obstacles is presented. These types of robots are designed to navigate different paths such as slippery trajectories, paths with obstacles, and other challenging paths. In addition, the robot can move its legs in different surface conditions and operate more flexibly with the help of wheels attached to the legs.

A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects.

Nanotechnology involves the utilization of materials with exceptional properties at the nanoscale. Over the past few years, nanotechnologies have demonstrated significant potential in improving human health, particularly in medical treatments. The self-assembly characteristic of RNA is a highly effective method for designing and constructing nanostructures using a combination of biological, chemical, and physical techniques from different fields.

Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl-induced hepatotoxicity in animal model using physical cold plasma.

Liver diseases have become widespread especially due to various factors of modern life. Although the effect of N-acetyl-L-cysteine (NAC) is investigated in the recovery of liver damage, gas plasma therapy can be identified as a promising candidate. Our study aimed to enhance the effectiveness of ineffective doses of NAC in stopping CCl-induced hepatotoxicity in rats by physical cold plasma.

Ratiometric fluorescence assay for ciprofloxacin in human blood serum and urine samples based on sulfur-doped carbon dots/rhodamine B nanohybrid encapsulated HKUST-1 metal-organic framework.

Preparation of carbon dots (CDs) from biomass waste is of great interest due to its low cost synthesis, environmental compatibility and functionalization without adding dangerous chemicals. Herein, S-doped carbon dot (SCD) was synthesized using agricultural waste as carbon precursors and modified in-situ with rhodamine B dye (SCD@RHB) to construct efficient flouresent probe. SCD@RHB was loaded into HKUST-1 metal-organic framework (SCD@RHB/HKUST-1) and the probe was employed as ratiometric flouresent (RF) sensor for the determination of ciprofloxacin (CIP) antibiotic in trace level.