Synthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments.

Background And Aim: Zinc oxide and copper oxide nanoparticles are known for their promising biological activities. This study aims to synthesize zinc oxide nanoparticles and copper-doped zinc oxide nanoparticles to harness the combined cytotoxic and anticancer effects of them in vitro and in vivo studies.

Methods: Zinc oxide nanoparticles, both doped and undoped, were synthesized using a chemical co-precipitation method.

Effect of E-learning clinical management of substance-dependent pregnant women on the knowledge and clinical skill performance of midwives: a randomized controlled trial.

Background: Drug use during pregnancy and post-partum undoubtedly significantly affects maternal and infant morbidity. Healthcare providers, especially midwives who care for pregnant and postpartum women, must possess adequate knowledge and clinical skills to manage their patients appropriately. This study aimed to determine the effect of an e-learning intervention on midwives' knowledge and clinical performance skills in caring for substance-dependent pregnant women during labor and post-partum.

Development of a new solar system integrating photovoltaic and thermoelectric modules with paraffin-based nanomaterials.

This study investigates a comprehensive enhancement strategy for photovoltaic (PV) panel efficiency, focusing on increasing electrical output through the integration of parabolic reflectors, advanced cooling mechanisms, and thermoelectric generation. Parabolic reflectors are implemented in the system to maximize solar irradiance on the PV panel's surface, while a specialized cooling system is introduced to regulate temperature distribution across the silicon layer. This cooling system consists of a finned duct filled with paraffin (RT35HC) and enhanced with SWCNT nanoparticles, which improve the thermal properties of the paraffin, facilitating more effective heat dissipation.

Structural, electrical and EMI shielding property of carbon nanotube decorated magnetic/ceramic nanoparticles.

To protect against harmful electromagnetic interference (EMI), it is crucial to fabricate composite with high total electromagnetic shielding efficiency (SE); In this study, FeNi-NiFeO-SiO nanoparticles (NPs) were synthesized using one-pot method and decorated on carbon nanotube's (CNT) sidewall. The final product was magnetic-ceramic/conductive (FeNi-NiFeO-SiO/MWCNT) nanocomposite. The EMI shielding characteristic of FeNi-NiFeO-SiO NPs and FeNi-NiFeO-SiO/MWCNT nanocomposite was investigated in the range of X and Ku frequency band.

Investigation of the anti-aging effects of active components of Artemia franciscana loaded in hyalurosome.

With the advancement of biotechnology in the marine industry, an increasing utilization of marine ingredients in skincare products has been observed in recent years. Encapsulating Artemia franciscana extract and its derivatives in a novel phospholipid vesicle called hyalurosome presents innovative strategies for drug delivery systems and anti-aging products. In this study, we developed nano hyalurosomes containing Artemia franciscana active components.

Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression.

Background: Type 2 Diabetes Mellitus (T2DM) is closely associated with the development of vascular damage in the heart. In this study, the researchers aimed to determine whether Aerobic Training (AT) and Vitamin D supplementation (Vit D) could alleviate heart complications and vascular damage caused by diabetes. The effects of an eight-week AT program and Vit D on the expression of miR-1, IGF-1 genes, and VEGF-B in the cardiomyocytes of rats with T2DM.

Predictive modeling of air quality in the Tehran megacity via deep learning techniques.

Air pollution is a significant challenge in metropolitan areas, where increasing amounts of air pollutants threaten public health and environmental safety. The present study aims to forecast the concentrations of various air pollutants, including CO, O, NO, SO, PM, and PM, from 2013 to 2023 in the Tehran megacity, Iran, via deep learning (DL) models and evaluate their effectiveness over conventional machine learning (ML) methods. Key driving variables, including temperature, relative humidity, dew point, wind speed, and air pressure, were considered.

Empagliflozin Ameliorates the Oxidative Stress Profile in Type 2 Diabetic Patients with Heart Failure and Reduced Ejection Fraction: Results of a Randomized, Double-blind, Placebo-controlled Study.

Introduction: In the present study, we evaluated the impact of empagliflozin on serum levels of oxidative stress parameters in individuals with type 2 diabetes (T2DM) who also suffer from heart failure with Reduced Ejection Fraction (HFrEF).

Methods: In this prospective, single-center clinical trial, 80 patients with T2DM and HFrEF, stabilized on guideline-directed heart failure therapy and classified as New York Heart Association functional (NYHA) functional classes II or III, were randomized to receive either empagliflozin (10 mg/daily) or a matching placebo for a duration of 12 weeks. Serum levels of malondialdehyde (MDA), along with the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured at baseline and after the 12-week treatment period.

In vitro Investigation of Antimicrobial and Antioxidant Properties of Green Silver Nanoparticles Synthesized Using Ephedra gerardiana Plant Extract.

Background: The increasing prevalence of antibiotic-resistant bacteria necessitates exploring nanotechnology as a potential solution for microbial elimination.

Objectives: This study aimed to investigate the antimicrobial and antioxidant effects of silver nanoparticles synthesized using aqueous extract from the Ephedra gerardiana (E. gerardiana) plant (EG@AgNPs).

Physicochemical and aromatic properties of iron-enriched tomato paste during storage.

In this study, tomato paste was fortified with iron compounds at 25, 50, and 75 ppm concentrations. The effect of adding these micronutrient iron concentrations on the paste's physical, mechanical, aromatic, and chemical properties was evaluated every 15 days over a 60-day, storage period. The results indicated a gradual decrease in pH, total soluble solids (TSS), and taste index, alongside an increase in total acidity (TA) for all treatments throughout the storage period.

Preparation, antioxidant, antibacterial, and in vivo evaluation of pomegranate flower extract nanofibers based on thiolated chitosan and thiolated gelatin for treating aphthous stomatitis.

Recurrent aphthous stomatitis (RAS) is a common condition that manifests as ulcerative lesions in the oral mucosa. In this study, bilayer, mucoadhesive nanofibers loaded with pomegranate flower extract (PFE) were prepared using thiolated gelatin (TGel) and thiolated chitosan (TCS) as the active layer and drug-free polycaprolactone (PCL) as the backing layer. Gelatin (Gel) and chitosan (CS) were successfully thiolated (proven by Ellman's assay, solubility, H NMR, FTIR, Raman spectroscopy, and XRD) and electrospun into active nanofibrous layers with a diameter of 356.

Amide modified cellulose-g-poly acrylic acid as a supple superabsorbent for water retention and soil conditioner.

Acrylamide has high hydrophilic properties due to the presence of hydrophilic amide functional groups and is frequently used to synthesize superabsorbents. However, the toxic and carcinogenic properties of acrylamide have caused environmental concerns. The main goal of this paper is the synthesis of superabsorbent with high water absorption from biodegradable and biocompatible cellulose polymer containing amide groups in the backbone of it instead of grafting harmful acrylamide monomers to cellulose.

Effects of Escherichia coli Nissle 1917 on immunity, blood constituents, antioxidant capacity, egg quality and performance in laying Japanese quail.

This study was conducted to evaluate the effects of E.coli Nissle 1917 (EcN) on immune responses, blood parameters, oxidative stress, egg quality, and performance of laying Japanese quail. A total of one-hundred day-old quail chicks were assigned to 1 of 4 treatments based on probiotic concentration: 1 (0 CFU/mL; control), 2 (10 CFU/mL), 3 (10 CFU/mL), and 4 (10 CFU/mL).

Design, synthesis, and structure-activity relationships of five-membered heterocyclic incorporated aryl(alkyl)azoles: From antiproliferative thiazoles to safer anticonvulsant oxadiazoles.

In the current study, a novel series of 1,2,4-oxadiazoles were designed, synthesized, and evaluated for their biological activities. A cell-based antiproliferative screening was accomplished on the newly synthesized 1,2,4-oxadiazoles along with our previously reported aryl(alkyl)azoles (AAAs) containing middle heterocyclic cores thiazole and oxazole. Among the tested compounds, naphthyl- thiazoles demonstrated higher antiproliferative activity and B3 was identified as the most potent compound with IC values in the range of 2.

A new species of Astragalus (Fabaceae) from the Irano-Turanian biodiversity hotspot: an integrative approach.

Background: The genus Astragalus is the largest and one of the most diverse genera of flowering plants, particularly in the Northern Hemisphere, with a significant concentration of species in the Irano-Turanian region. Within this genus, section Hymenostegis is notable for its complexity and high levels of endemism, especially in northwestern Iran. During recent field explorations in West Azarbaijan province, a distinct population of Astragalus was identified, differing from known species within section Hymenostegis.

BDNF and GSK-3beta expression changes underlie the beneficial effects of crocin on behavioral alterations in a rat model of autism induced by prenatal valproic acid administration.

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder characterized by impairments in social interaction, language, and communication and induction of stereotypic behavior. In rodents, prenatal administration of valproic acid (often on 12.5 gestational days) is used for the induction of an ASD-like model.

Effect of Total and Partial Meal Replacements on Factors Related to Glucose Metabolism: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Context: Although some evidence shows the beneficial effects of meal replacements (MRs) on glucose metabolism as one of the main factors of diabetes, there are still no comprehensive findings in this field.

Objective: We investigated the effects of total and partial MRs on fasting blood sugar (FBS), insulin, glycated hemoglobin (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) in this comprehensive study and meta-analysis.

Data Sources: To find pertinent randomized controlled trials (RCTs) up to March 2024, databases including PubMed/Medline, Web of Science, Scopus, and Embase were searched.

In silico MLVA Analysis of Brucella melitensis from Human and Livestock in Iran.

Brucellosis, a zoonotic disease caused by Brucella spp. globally, is of great significance not only to livestock but also to public health. The most significant of the twelve species is Brucella melitensis.

Marker-assisted selection in segregating populations of tomatoes for resistance to TYLCV, ToMV, and Fusarium wilt.

Background: Tomato yellow leaf curl virus (TYLCV), tomato mosaic virus (ToMV), and Fusarium wilt are three of tomatoes' most important viral and fungal diseases.

Methods And Results: In this study, the application of molecular markers associated with tomato yellow leaf curl virus resistance gene (Ty1), tomato mosaic virus resistance gene (Tm2), and Fusarium wilt resistance gene (I-1) (linked marker) were evaluated. In order to optimize and use SNP markers (by HRM diagnostic method) and SCAR markers, segregating populations of tomatoes were produced by self-pollination of commercial hybrid cultivars.

Role of NEAT1 and HOTAIR long non-coding RNAs in Behcet's Disease pathogenesis and their correlation with target inflammatory cytokines.

Background: Recent studies have highlighted the potential role of several long non-coding RNAs (lncRNAs) in the pathogenesis of Behçet's disease (BD). This study investigated the expression profiles of lncRNA NEAT1 and lncRNA HOTAIR, and their target cytokine genes, IL-6 and TNF-α, in active and inactive BD patients.

Methods: This cross-sectional study was conducted on peripheral blood mononuclear cells (PBMCs) obtained from 25 BD patients and 25 age-sex-matched healthy controls (HCs).

Bike-Riding Training may Improve Communication Skills and Stereotyped Behavior in Adolescents With Autism.

This research aimed to establish whether 12 weeks of bicycle-riding skills exercises with massed and distributed practice frequency at low and high intensity affect communication performance and stereotyped behavior among adolescent boys with autism. Fifty autistic boys aged 13.3 ± 1.

Protective Effects of Heat-Killed Lactobacilli against Plasma-Induced Neurotoxicity in Multiple Sclerosis.

Heat-killed lactobacilli seem to have protective effects against oxidative stress and neurotoxicity. This study aimed to evaluate the antioxidant properties of specific heat-killed lactobacilli extracts and determine their neuroprotective effects against the neurotoxicity induced by blood plasma from people with multiple sclerosis (MS). The antioxidant activity of the three heat-killed lactobacilli was measured using the DPPH assay.

Predictive Value of Complete Blood Count (CBC)-Derived Indices-C-Reactive-Protein-Albumin-Lymphocyte index (CALLY), Glucose-to-Lymphocyte Ratio (GLR), Prognostic Nutritional Index (PNI), Hemoglobin, Albumin, Lymphocyte, Platelet (HALP), and Controlling Nutritional Status (COUNT)-on Body Composition Changes After Bariatric Surgery.

Background/objective: Obesity is linked to increased risks of cardiovascular disease, diabetes, and certain cancers. Bariatric surgery (BS) aids in weight management, significantly altering body composition. This study evaluates the predictive value of five complete blood count (CBC)-derived indices [C-reactive-protein-albumin-lymphocyte (CALLY), glucose-to-lymphocyte ratio (GLR), prognostic nutritional index (PNI), hemoglobin, albumin, lymphocyte, platelet (HALP), and controlling nutritional status (COUNT)] on body composition changes post-BS.

Identification and Characterization of Acanthamoeba from Contact Lens Care Solutions and Hospital Environments in the Ophthalmology Wards and Operating Rooms in Southeastern Iran.

Objective: Different Acanthamoeba species are among the most ubiquitous organisms causing serious diseases in humans including central nervous system (CNS) and eye infections. Contact lenses, lens care solutions and the hospital environments particularly the indoor and outdoor environments of ophthalmology wards where people are present with different types of eye diseases, are the potential sources of human infection. The purpose of the present study was the molecular investigation of free-living amoebae in the used contact lenses, lens care solutions and hospital samples from the ophthalmology wards and operating rooms in a referral hospital in southeastern Iran.