Diagnosis and prognosis of melanoma from dermoscopy images using machine learning and deep learning: a systematic literature review.

Background: Melanoma is a highly aggressive skin cancer, where early and accurate diagnosis is crucial to improve patient outcomes. Dermoscopy, a non-invasive imaging technique, aids in melanoma detection but can be limited by subjective interpretation. Recently, machine learning and deep learning techniques have shown promise in enhancing diagnostic precision by automating the analysis of dermoscopy images.

Upregulated PCAT-1 predicts poor prognosis and reduced immune cell infiltration in head and neck squamous cell carcinoma through the miR-145-5p / FSCN-1 axis.

Background: LncRNA PCAT-1 is known to promote cancer proliferation, invasion, and metastasis. However, its significance in HNSCC is not fully understood. This research investigates how the PCAT-1 / miR-145-5p / FSCN-1 axis promote HNSCC.

Metal-Coordinated Histidine-Functionalized Redox-Responsive Polyethyleneimine as a Smart Gene Delivery Vector.

Despite significant advancements in gene delivery and CRISPR technology, several challenges remain. Chief among these are overcoming serum inhibition and achieving high transfection efficiency with minimal cytotoxicity. To address these issues, there is a need for novel vectors that exhibit lower toxicity, maintain stability in serum-rich environments, and effectively deliver plasmids of various sizes across diverse cell types.

Spectrum of ARSA mutations in Iranian patients with metachromatic leukodystrophy.

Metachromatic leukodystrophy (MLD) is an autosomal recessive disorder caused by mutations in the arylsulfatase A (ARSA) gene. Few studies have assessed the spectrum of ARSA mutations among Iranian patients. Here, we report eight Iranian patients with clinical features of MLD.

Hybrid stochastic and robust optimization of a hybrid system with fuel cell for building electrification using an improved arithmetic optimization algorithm.

This paper proposes a hybrid stochastic-robust optimization framework for sizing a photovoltaic/tidal/fuel cell (PV/TDL/FC) system to meet an annual educational building demand based on hydrogen storage via unscented transformation (UT), and information gap decision theory-based risk-averse strategy (IGDT-RA). The hybrid framework integrates the strengths of UT for scenario generation and IGDT-RA (hybrid UT-IGDT-RA) for optimizing the system robustness and maximum uncertainty radius (MRU) of building energy demand and renewable resource generation. The deterministic model focuses on minimizing the cost of energy production over the project's lifespan (CEPLS) and considers a reliability constraint defined as the demand shortage probability (DSHP).

A novel cobalt oxide nanoparticle conjugated with ellagic acid arrests the cell cycle in human liver cancer cell line.

The current chemotherapy treatments for liver cancer have shown limited effectiveness. Therefore, there is an urgent need to develop new drugs to combat this disease more effectively. This study reports synthesis of cobalt oxide nanoparticles coated with glucose, and conjugated with Ellagic acid.

Synergetic effects of nano-boehmite and Y nano-zeolite on catalytic cracking of residue oil.

Boehmite nanoparticles and NaY nanozeolite were synthesized by co-precipitation and hydrothermal methods, respectively, and characterized by XRD, FT-IR, TG-DTA, BET, and SEM techniques. XRD and BET analyses demonstrated the formation of boehmite nanoparticles with a surface area of 350 m/g and high crystallinity NaY nanozeolite with a surface area of 957 m/g. In order to evaluate the effect of the content of the mesoporous boehmite nanoparticles on the catalytic performance of the Residue Fluid Catalytic Cracking (RFCC) catalyst, alumina active matrix-based and silica inactive matrix-based catalysts were prepared.

A comparative study of LQU and LQFI in general qubit-qutrit axially symmetric states.

We derive the compact closed forms of local quantum uncertainty (LQU) and local quantum Fisher information (LQFI) for hybrid qubit-qutrit axially symmetric (AS) states. This allows us to study the quantum correlations in detail and present some essentially novel results for spin-(1/2, 1) systems, the Hamiltonian of which contains ten independent types of physically important parameters. As an application of the derived formulas, we study the behavior of these two quantum correlation measures at thermal equilibrium.

Prognostic impact of chronic obstructive pulmonary disease on short-term and long-term outcomes following coronary artery bypass grafting.

Chronic obstructive pulmonary disease (COPD) is a common condition that complicates major surgeries like coronary artery bypass grafting (CABG). This study aims to evaluate the impact of COPD on the outcome of CABG. A registry-based retrospective cohort study included individuals who received CABG between 2009 and 2016.

Titanium dioxide -mediated regulation of enzymatic and non-enzymatic antioxidants, pigments, and diosgenin content promotes cold stress tolerance in Trigonella foenum-graecum L.

Abiotic stresses, notably cold stress, significantly influence various aspects of plant development and reproduction. Various approaches have been proposed to counteract the adverse impacts of cold stress on plant productivity. The unique properties of nanoparticles contribute to an enhanced tolerance of plants to challenging conditions.

The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021.

Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from 1990 to 2021. We analysed publicly accessible data from the Global Burden of Disease 2021 study to present findings on the incidence, deaths, and disability-adjusted life years (DALYs) associated with prostate cancer.

Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer.

The simultaneous administration of multiple drugs within identical nanocarriers to cancer cells or tissues can result in the effective action of drugs at reduced concentrations. In this investigation, PAMAM dendrimers (G4-PAMAM) were employed to link with methotrexate (MTX) using DCC/NHS chemistry and followed by the entrapment of curcumin (Cur) within it. The establishment of covalent bonds between MTX and the PAMAM dendrimer led to PAMAM-MTX interaction, verified and described through FT-IR.

Development of a gum tragacanth-coated nanoparticle system for controlled release of plant extracts against Erwinia amylovora.

Fire blight, caused by Erwinia amylovora, is a significant threat to fruit crops, with limited biocontrol methods. This study aimed to develop a nanosystem using mesoporous silica nanoparticles (MSNs) loaded with a phenolic plant extract (ZP) derived from Myrtus communis, Thymus vulgaris, and Curcuma longa, and coated with natural biopolymers Gum Tragacanth (GT) and sodium alginate (SA). The MSNs were synthesized and characterized by XRD, FTIR, and TEM, exhibiting a specific surface area of about 750 m/g and an average pore diameter of 5 nm.

A Schiff base-functionalized chitosan magnetic bio-nanocomposite for efficient removal of Pb (II) and Cd (II) ions from aqueous solutions.

The rapid industrialization and human activities in catchments have posed notable global challenges in removing of heavy metal contaminants from wastewater. Here, Schiff-bases (SB) of cyanoguanidine (CG) and salicylaldehyde (SA) were covalently grafted on a magnetic nanocomposite of chitosan to form a hybrid magnetic nanostructure (FeO@CS-CGSB). The synthesized structure was characterized using various techniques such as Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), dynamic light scattering (DLS), zeta potential, and Brunauer-Emmett-Teller surface area analysis (BET).

Tartaric acid, an effective additive to improve the surface properties and bio-corrosion resistance of HA-coated magnesium-based implants.

In this research, tartaric acid was used to enhance the hydroxyapatite coating on AZ31 Mg alloy substrate through post-treatment and direct addition methods, and the corrosion resistance and biological activity of the samples were investigated. The parameters of concentration, immersion time, and pH of the coating solution were optimized by Electrochemical Impedance Spectroscopy (EIS) and Direct Current (DC) Polarization techniques. According to EIS results in the post-treatment method, tartaric acid with a concentration of 1 g/L, pH = 9 and immersion time of 2 min, increased the corrosion resistance of hydroxyapatite coating from 3630 to about 18,763 Ω.

Decoding the role of ghrelin and its interactions with central signaling pathways in avian appetite regulation.

Ghrelin, a peptide hormone primarily produced in the enteroendocrine cells of the gastrointestinal tract, plays a vital role in regulating food intake, and energy balance in avian species. This review examines the complex interactions between ghrelin and the central signaling pathways associated with hunger regulation in birds. In contrast to mammals, where ghrelin typically promotes feeding behavior, its effects in birds appear more nuanced, exhibiting anorexigenic properties under certain conditions.

Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing.

Dermatologists have been interested in recent advancements in regenerative therapy. Current research is actively investigating the possibility of placental tissue derivatives to decelerate the skin aging process, enhance skin regeneration, reduce scarring, and prevent hair loss. Amniotic membranes (AM) play a crucial role in regenerative medicine as they serve as a suitable means of transporting stem cells, growth hormones, cytokines, and other essential compounds.

Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system.

Preserving fertility is important in men under radiation therapy because healthy cells are also affected by radiation. Supplementation with antioxidants is a controversial issue in this process. Designing a biocompatible delivery system containing hydrophobic antioxidants to release control may solve these disagreements.

Dengue virus infection: how platelet-leukocyte crosstalk shapes thrombotic events and inflammation.

Dengue virus (DENV) poses a considerable threat to public health on a global scale, since about two-thirds of the world's population is currently at risk of contracting this arbovirus. Being transmitted by mosquitoes, this virus is associated with a range of illnesses and a small percentage of infected individuals might suffer from severe vascular leakage. This leakage leads to hypovolemic shock syndrome, generally known as dengue shock syndrome, organ failure, and bleeding complications.

Patient-Reported Outcomes Following Systemic Antibiotic Adjunct to Nonsurgical Treatment of Periodontitis: A Randomized Controlled Clinical Trial.

Objectives: Considering the importance of patient-centered care, we aimed to evaluate the impact of systemic antibiotics on oral health-related quality of life during nonsurgical periodontal treatment. This controlled trial addresses a gap in understanding how systemic antibiotics influence patient-reported outcomes, focusing on Stage III periodontitis.

Materials And Methods: Sixty-one adults participated in a double-blind, randomized clinical trial, with participants divided into two groups: the test group, which received antibiotics, and the control group.

A Comparative Study of the Use of a 980 nm Diode Laser and 10600nm CO2 in the Treatment of Gingival Melanin Pigmentation.

Gingival depigmentation with the help of lasers is known as an effective technique. The aim of this study was to compare the efficiency of 980nm diode and CO2 lasers in the treatment of gingival hyperpigmentation. In this clinical trial study, 14 individuals (8 females and 6 males) with the age range of 19 to 47 years were selected.

Design, simulation, and manufacturing of analyzer optical cell for detection and measurement of injectable odorant at pressure reduction stations.

The absence of a mercaptan compounds analyzer in natural gas pressure reduction stations (PRS) odorizer leads to inaccuracies in the injection dosage, often resulting in quantities beyond standard limits and consequently increasing odorant consumption. Insufficient odorant levels in natural gas can pose safety risks to consumers, as the gas may become odorless at the end of the pipeline. Therefore, accurate determination of the concentration of key odorant compounds in natural gas can reduce both costs and environmental risks.

Eco-friendly synthesis of gold nanoparticles via peel extract: Unveiling their multifaceted biological and catalytic potentials.

Recent advancements in nanoscience underscore the transformative potential of nanomaterials in environmental and biological applications. In this study, we synthesized gold nanoparticles (Au@ NPs) using an eco-friendly and cost-effective approach, leveraging peel extract as both a capping and reducing agent. This method presents a sustainable alternative to traditional chemical agents.

Development and validation of a patient experience assessment questionnaire for evaluating hospital care in Iran.

Purpose: Understanding patient experience is crucial for advancing patient-centered care and improving hospital service quality. This study aimed to design and validate a Persian version of a patient experience assessment questionnaire to evaluate hospital services.

Methods: This descriptive-analytical study on tool development was conducted cross-sectionally during 2021-2022 in Iran.

Designing of a wide-area power system stabilizer using an exponential distribution optimizer and fuzzy controller considering time delays.

In this paper, explore the effectiveness of a new Wide Area Fuzzy Power System Stabilizer (WAFPSS), optimized using the Exponential Distribution Optimization (EDO) algorithm, and applied to an IEEE three-area, six-machine power system model. This research primarily focuses on assessing the stabilizer's capability to dampen inter-area oscillations, a critical challenge in power grid operations. Through extensive simulations, the study demonstrates how the WAFPSS enhances stability and reliability under a variety of operational conditions characterized by different communication delay patterns.