Aging and voluntary exercise's effects on Aβ1-42 levels, endoplasmic reticulum stress factors, and apoptosis in the hippocampus of old male rats.

Within the aging cortex, amyloid beta peptide (Aβ) is a crucial element of the senile plaques, a hallmark feature often observed in cases of Alzheimer's disease (AD). The UPR (unfolded protein response), a cellular mechanism for protein folding, is switched on by Aβ accumulation. Endoplasmic reticulum (ER) stress has been identified as playing a role in aging and the development of neurodegenerative diseases.

Highly Selective and Sensitive Visual Detection of Fe using a Simple Quinazoline-Based Colorimetric Sensor.

Among the various cations, the Fe ion is one of the most critical transition metal ions in living cells for many cellular functions and enzymatic activities. The decrease or overloading of Fe can lead to different disruptions in humans. Also, Fe, highly toxic, is very common in all industrial wastewater.

[In]In-RM2: a high potential agent for SPECT imaging of GRPR-expressing tumors.

Gastrin-releasing peptide receptors (GRPRs) overexpressed in many cancers are known as promising biomarkers to target tumors such as prostate, breast, and lung cancers. As the early diagnosis of the cancers can serve for better treatment of the patients, [In]In-DOTA-Pip-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ([In]In-RM2) was prepared using an in-house developed Sn/In generator. 0.

An economical synthesis of benzodiazepines using ACT@IRMOF core-shell as a potential eco-friendly catalyst through the activated carbon of thymus plant (ACT).

Here, a straightforward design is employed to synthesize a nanocatalyst based on a carbon-activated modified metal-organic framework using the solvothermal method. This work presents a simple and practical approach for producing the activated carbon derived from the Thymus plant (ACT) modified with amine-functionalized isoreticular metal-organic framework-3 (IRMOF-3) to create an ACT@IRMOF-3 core-shell structure. Successful functionalization was confirmed through N adsorption isotherms, FT-IR, FE-SEM, TEM, EDS, elemental mapping, TGA, and XRD analysis.

The Role of Physical Activity in COVID-19 Mortality Rate: A Cross-Sectional Study.

Background: Recent evidence suggests a negative correlation between physical activity and the incidence and severity of noncommunicable chronic diseases like cardiovascular disease, diabetes, and respiratory infections. This study explores the potential influence of physical activity levels on the mortality rate and coronavirus disease (COVID-19) recovery.

Materials And Methods: This descriptive analytical cross-sectional study evaluated 175 Polymerase Chain Reaction (PCR)-confirmed COVID-19 patients admitted to Baqiyatallah Hospital.

Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 diabetes models in mice.

Background: Structural heart disease is one of the leading causes of death in people with type 2 diabetes (T2D), which is not known to have an effect on exercise training. The aim of this study was to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on heart tissue structure, the serum level of FGF21 and the heart tissue level of β-Klotho, an FGF21 coreceptor, in HFD and HFD + STZ-induced diabetic mice.

Methods: Thirty-six male C57BL/6J mice were divided into high-fat diet (HFD) and normal chow diet (ND) groups.

Manganese ferrite-graphite oxide-chitosan nanocomposite for efficient dye removal from aqueous and textile wastewater under UV and sunlight irradiation.

This study presents the development and characterization of manganese ferrite (MnFeO)-based nanocomposites with graphite oxide (GO) and chitosan (CS) for efficient dye removal from textile wastewater and aqueous solution. Comprehensive characterization was performed using FT-IR, Raman, XRD, BET, SEM, DRS and Zeta potential techniques. XRD analysis confirmed the cubic spinel structure of MnFeO, with characteristic peaks at 2θ = 32, 35, 48, 53, 62, and 64°.

The impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran: an interrupted time series analysis.

Background: The Covid-19 pandemic has posed unprecedented challenges to healthcare systems worldwide, affecting routine medical services, including for cancer patients. This study investigates the impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran.

Methods: We conducted an interrupted time series analysis (ITSA) on data collected from electronic medical records.

Agro-morphological characterization and assessment of metabolic profiling and anticancer activities in various tribulus (Tribulus terrestris L.) populations.

Tribulus terrestris L. from the family of Zygophyllaceae, which is rich in saponin compounds, especially diosgenin, has various biological properties, such as anti-inflammation, anti-Alzheimer, anti-obesity, anti-diabetes, anti-leukemia, and anti-cancer activities, due to these compounds. This research aimed to study the diversity of agro-morphological and phytochemical traits and anti-proliferative activity against human prostate cancer cells (PC3) of T.

The expression of the lncRNAs USP30-AS1, ELFN1-AS1, GAS8-AS1, and SNHG11 in breast cancer samples from Iranian patients from 2014 to 2019: a cross-sectional study.

Objective: Breast cancer is a widely prevalent and life-threatening malignancy that affects women worldwide. The identification of novel molecular markers associated with tumor progression is highly important for enhancing early detection, tailoring treatment approaches, and monitoring therapeutic outcomes. In this study, we investigated the expression patterns of four long noncoding RNAs (lncRNAs): USP30 antisense RNA1 (USP30-AS1), ELFN1 antisense RNA1 (ELFN1-AS1), GAS8 antisense RNA1 (GAS8-AS1), and small nucleolar RNA host gene 11 (SNHG11).

A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer.

Background: Colorectal cancer (CRC) is a globally prevalent malignancy, primarily affecting the colon and rectum, characterized by uncontrolled cellular changes in the intestinal wall lining. Recent evidence underlines the significant role of the CXCL12/CXCR4 axis in the development of CRC, suggesting that inhibiting this pathway could be a promising therapeutic approach. This study focuses on investigating the potential of N, N''-thiocarbonylbis (N'-(3,4-dimethyl phenyl)-2,2,2-trifluoroacetimidamide) (A1), a novel fluorinated CXCR4 inhibitor, through a comprehensive analysis encompassing in silico, in vitro, and in vivo studies.

Smart estimation of protective antioxidant enzymes' activity in savory (Satureja rechingeri L.) under drought stress and soil amendments.

Savory (Satureja rechingeri L.) is one of Iran's most important medicinal plants, having low irrigation needs, and thus is considered one of the most valuable plants for cultivation in arid and semi-arid regions, especially under drought conditions. The current research was carried out to develop a genetic algorithm-based artificial neural network (ΑΝΝ) model able of simulating the levels of antioxidants in savory when using soil amendments [biochar (BC) and superabsorbent (SA)] under drought.

Controlling the drug delivery efficiency of chitosan-based systems through silver nanoparticles and oxygen plasma.

Today, curcumin's therapeutic properties are used in drug delivery systems. In this work, chitosan (CS) /Montmorillonite (MMT) hydrogels were synthesized to improve the performance of curcumin molecules. According to the results, drug release characteristics of CS/MMT/curcumin highly depend on the pH of the environment and properties of Ag nanoparticles.

The effect of different textured foot orthoses on ankle and knee joint muscles co-contraction in male and female older adults during walking.

Background: Foot orthoses have been considered to affect static and dynamic functional capacity and could help older adults maintain balance while walking. However, the impact of textured foot orthoses over co-contraction strategies remains uncertain. Therefore, this study aimed to assess the effect of different textured foot orthoses on ankle and knee joint muscle co-contraction in male and female older adults during walking.

Super hydrophilic and super oleophobic carbon nanotube/TiO composite membranes for efficient separation of algal-derived oil/water emulsions.

The separation of oil from microalgae aqueous emulsions is a critical step in producing algal-derived biofuels and nutraceuticals. This study presents the development of super hydrophilic and super oleophobic composite membranes to efficiently separate algal oil from oil/water emulsions. Carbon nanotubes (CNTs) were functionalized with polydopamine (PDA), polyethylene glycol (PEG), and titanium dioxide (TiO) nanoparticles and coated onto a mixed cellulose ester (MCE) substrate to fabricate the composite membranes.

The functional role of LncRNA HOXA-AS2 in multiple human cancers.

Humans have more than 270,000 lncRNAs. Among these, lncRNA HOXA-AS2 is considered a transformative gene involved in various cellular processes, including cell proliferation, apoptosis, migration, and invasion. Thus, it can be regarded as a potential tumor marker for both diagnosis and prognosis.

In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration.

Tendon injuries present significant medical, social, and economic challenges globally. Despite advancements in tendon injury repair techniques, outcomes remain suboptimal due to inferior tissue quality and functionality. Tissue engineering offers a promising avenue for tendon regeneration, with biocompatible scaffolds playing a crucial role.

Climate change impact on water treatment plants: analysis of chlorophyll-a levels and process performance.

Climate change significantly impacts the risk of eutrophication and, consequently, chlorophyll-a (Chl-a) concentrations. Understanding the impact of water flows is a crucial first step in developing insights into future patterns of change and associated risks. In this study, the Statistical DownScaling Model (SDSM)-a widely used daily downscaling method-is implemented to produce downscaled local climate variables, which serve as input for simulating future hydro-climate conditions using a hydrological model.

Machine learning techniques for non-destructive estimation of plum fruit weight.

Plum fruit fresh weight (FW) estimation is crucial for various agricultural practices, including yield prediction, quality control, and market pricing. Traditional methods for estimating fruit weight are often destructive, time-consuming, and labor-intensive. In this study, we addressed the problem of predicting plum FW using artificial intelligence (AI) methods based on fruit dimensions.