1 results match your criteria: "INSERM and Univ. Limoges[Affiliation]"
Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line.
Metabolomics
September 2023
U1248 Pharmacology & Transplantation, INSERM and Univ. Limoges, 87000, Limoges, France.
Article Synopsis
- The study investigates how ischemia-reperfusion injury (IRI) affects kidney transplant function, particularly looking at how hypoxia and reoxygenation influence proximal transporters in kidney cells.
- Research involved culturing human tubular cells under different hypoxia and reoxygenation conditions, analyzing changes in transporter gene expression, and using metabolomics to explore metabolic shifts.
- Findings revealed specific upregulation and downregulation of transporter genes during hypoxia and reoxygenation, though no direct link was found between transporter expression and metabolic changes, suggesting the need for more focused research on individual transporters.