6 results match your criteria: "INFINITE - Institute for Translational Research in Inflammation Inserm Univ. Lille[Affiliation]"
Studying antigen-specific T cells through a streamlined, whole blood-based extracellular approach.
Cytometry A
April 2024
CHU Lille, Institut d'Immunologie, U1286 - INFINITE - Institute for Translational Research in Inflammation Inserm Univ. Lille, Lille, France.
Techniques currently used for the study of antigen-specific T-cell responses are either poorly informative or require a heavy workload. Consequently, many perspectives associated with the broader study of such approaches remain mostly unexplored in translational research. However, these could benefit many fields including but not limited to infectious diseases, oncology, and vaccination.
View Article and Find Full Text PDFSerum neutralization of SARS coronavirus 2 Omicron sublineages BA.1 and BA.2 and cellular immune responses 3 months after booster vaccination.
Clin Microbiol Infect
February 2023
CHU Lille, Institut d'Immunologie, INFINITE - Institute for Translational Research in Inflammation Inserm Univ. Lille, France. Electronic address:
Article Synopsis
- This study explored the effectiveness of the BNT162b2 booster vaccine on neutralizing antibodies and T cell responses in healthcare workers against the Omicron sublineages BA.1 and BA.2, before and three months after vaccination.
- Results showed that before the booster, a small percentage of participants had measurable neutralizing activity, but by three months post-booster, nearly all had developed strong antibody responses against Delta and Omicron variants, although the levels were lower for BA.1 and BA.2 than for Delta.
- Participants with recent SARS-CoV-2 infections maintained stable antibody levels, while those without infections experienced a decrease in neutralizing antibody titres over the three-month period.
Evaluation of a rapid semiquantitative lateral flow assay for the prediction of serum neutralizing activity against SARS-CoV-2 variants.
J Clin Virol
October 2022
Univ Lille, CHU Lille, Laboratoire de Virologie ULR3610, F-59000 Lille, France. Electronic address:
Background: Neutralizing antibodies (NAbs) against SARS-CoV-2 have been shown to correlate with protection against infection. Simple tools such as lateral flow assays (LFA) that can accurately measure NAbs may be useful for monitoring anti-SARS-CoV-2 immunity in the future.
Objectives: We assessed the performance of the ichroma™ COVID-19 nAb test, a rapid semiquantitative LFA, for the prediction of serum neutralizing activity against SARS-CoV-2 variants.
Cutaneous manifestations of lymphoid-variant hypereosinophilic syndrome.
Br J Dermatol
December 2022
Department of Dermatology, Saint-Louis Hospital, AP-HP, Paris, France.
Immunogenicity of BNT162b2 vaccine booster against SARS-CoV-2 Delta and Omicron variants in nursing home residents: A prospective observational study in older adults aged from 68 to 98 years.
Lancet Reg Health Eur
June 2022
CHU Lille, Institut d'Immunologie, U1286 - INFINITE - Institute for Translational Research in Inflammation Inserm Univ. Lille, F-59000, Lille, France.
Background: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents.
Methods: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta and Omicron variants were compared before and up to three months after the BNT162b2 booster dose, in NH residents without COVID-19 (COVID-19 naive) or with COVID-19 prior to initial vaccination (COVID-19 recovered).
Findings: 106 NH residents (median [interquartile range] age: 86·5 [81;91] years) were included.
Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People.
Front Immunol
January 2022
Institut d'Immunologie, U1286 - INFINITE - Institute for Translational Research in Inflammation Inserm Univ. Lille, Centre Hospitalier Universitaire (CHU) Lille, Lille, France.
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell response.
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