Demystifying the role of MMP9 and TIMP-1 as markers of lung imaging and functional abnormality of COVID-19.

Introduction: This study aimed to analyze the levels of MMP-9 and TIMP-1 as biomarkers for identifying lung anatomical and functional abnormalities in coronavirus disease 2019 (COVID-19).

Methodology: Adult COVID-19 patients hospitalized between October and December 2021 were included in the study. MMP-9 and TIMP-1 levels were measured from the blood.

Effect of hemoperfusion in critically ill COVID-19 patients: a case series from a single-center hospital in Indonesia.

Introduction: Hemoperfusion (HP), a blood filtration method targeting the removal of toxins and inflammatory elements, was investigated in this study. The objective was to present the observations in four individuals with confirmed COVID-19 who underwent several rounds of HP utilizing the HA330 cartridge at a hospital in Indonesia.

Case Studies: We report four cases of COVID-19 patients who underwent HP.

Clinical patterns and outcomes of patients affected by primary malignant melanoma of the oral mucosa: A European multicenter retrospective chart review.

Introduction: The purpose of this European multicenter study was to describe and assess the characteristics, diagnosis, management, and recurrence of oral malignant melanoma at different European oral and maxillofacial surgery centers.

Materials And Methods: This study was based on a systematic computer-assisted database that allowed the recording of data for all primary oral mucosal melanomas treated in the involved surgical units across Europe between January 1, 2003 and December 31, 2022. The following data were recorded for each patient: gender, age, site, TNM staging, metastases, symptoms, imaging features, histopathological features, treatment, complications, recurrence, follow up, and survival.

Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries.

Dementia, is a critical global public health challenge with no effective pharmacological treatments. Recent research highlights the significant role of lifestyle interventions, particularly physical activity and dietary habits, in mitigating cognitive decline among the elderly and preventing the progression to dementia in individuals with Mild Cognitive Impairment (MCI). This comprehensive review explores the impact of physical exercise and dietary approaches on cognitive health, comparing strategies adopted in Western and Asian countries.

Efficacy and Safety of Endovenous Microwave Ablation versus Endovenous Laser Ablation for Varicose Veins in Chronic Great Saphenous Vein Insufficiency: A Meta-Analysis.

Background: Although guidelines have established endovenous laser ablation (EVLA) as the first-line option for patients with varicose veins (VVs) in chronic Great saphenous vein (GSV) insufficiency, however, Chronic Vein Insufficiency (CVI) remains a significant healthcare burden. Endovenous microwave ablation (EMA) is a promising alternative. This review aims to analyze the Endovenous Microwave Ablation versus Endovenous Laser Ablation for Varicose Veins in Chronic Great Saphenous Vein Insufficiency METHODS: Randomized controlled trials (RCTs) and cohort studies across PubMed, Scopus, Science Direct, and the Cochrane Library up to November 11, 2024 was searched.

Muscle-Guided Mapping of the Post-Traumatic Heterotopic Ossification of the Elbow: A Novel CT-Based Study.

Background: Heterotopic ossification (HO) involves abnormal bone formation in soft tissues near joints, commonly occurring after elbow trauma or surgery, leading to pain and functional limitations. Previous studies have primarily characterized HO distribution based on bony landmarks, lacking a detailed investigation into the characteristics of its distribution in periarticular soft tissue in post-traumatic elbows. This study aimed to (1) develop a muscle-guided classification system using computed tomography (CT) to map HO relative to elbow muscle-tendon units and (2) investigate correlations between HO location and severity.

When unusual corpus alienum invade the urethra in schizophrenia patients: A case report.

Introduction: The presence of foreign or unexpected external objects in the urinary tract, including the urethra, is a rare case. This case is a challenge for patients with schizophrenia. This case report presents when the unusual corpus alienum invades the urethra in schizophrenia patients.

RNAi-based biocontrol for crops: a revised expectation for a non-recent technology.

The exogenous application of RNAi technology offers new promises for crops improvement. Cell-based or synthetically produced strands are economical, non-transgenic and could induce the same responses. The substantial population growth demands novel strategies to produce crops without further damaging the environment.

Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach.

The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines.

Phytomedicine Potential of Root and Its Constituents: Targeting Alzheimer's Disease.

Alzheimer's disease (AD) is a neurodegenerative condition characterized by a gradual decline in cognitive function, for which few effective treatments exist. This study investigated the neuroprotective potential of root extract and its key constituents (baicalein, chrysin, oroxylin A) against AD hallmarks. The extract and its constituents exhibited antioxidant activity in the DPPH assay.

Plant-Based Functional Foods from Borneo.

Borneo, the third-largest island in the world, is shared between Malaysia (Sabah and Sarawak), Indonesia (Kalimantan) and Brunei. As a biodiversity hotspot, it is home to about 15,000 flowering plants and 3000 tree species, of which many are endemic to the region. Locally derived plant-based foods are gaining popularity due to their lower environmental impact, contribution to food sustainability and health benefits.

The Potential Application of Nanocarriers in Delivering Topical Antioxidants.

The imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially in the skin. In such conditions, supplementing exogenous antioxidants may help the body prevent the negative effect of ROS. However, the skin, as the outermost barrier of the body, provides a perfect barricade, making the antioxidant delivery complicated.

Microbial Pattern in Amniotic Fluid from Women with Premature Rupture of Membranes and Meconium-Stained Fluid.

Intra-amniotic infection (IAI), also known as chorioamnionitis, is a major cause of maternal and neonatal infection that occurs during pregnancy, labor and delivery, or in the postpartum period. Conditions such as meconium-stained amniotic fluid (MSAF) and premature rupture of membranes (PROMs) are recognized risk factors for amniotic fluid infection. This study identifies the microbial patterns in the amniotic fluid of women with PROMs and MSAF to determine the presence and types of bacterial growth.

Targeting T-Cell Activation for Malaria Immunotherapy: Scoping Review.

Malaria remains a critical global health issue due to high mortality rates, drug resistance, and low treatment efficacy. The genetic variability of proteins complicates the development of long-lasting immunity, as it impedes the human immune system's ability to sustain effective responses. T cells play a crucial role in combating malaria, but the parasite's complex life cycle-spanning liver and blood stages-presents significant challenges in effectively activating and targeting these cells.

Intelligent Intrusion Detection System Against Various Attacks Based on a Hybrid Deep Learning Algorithm.

The Internet of Things (IoT) has emerged as a crucial element in everyday life. The IoT environment is currently facing significant security concerns due to the numerous problems related to its architecture and supporting technology. In order to guarantee the complete security of the IoT, it is important to deal with these challenges.

Pic2Plate: A Vision-Language and Retrieval-Augmented Framework for Personalized Recipe Recommendations.

Choosing nutritious foods is essential for daily health, but finding recipes that match available ingredients and dietary preferences can be challenging. Traditional recommendation methods often lack personalization and accurate ingredient recognition. Personalized systems address this by integrating user preferences, dietary needs, and ingredient availability.

Enhancement of Spurious Signal Suppression in Microstrip Mixers by Load Resistor Termination.

The mixer is an essential component in RF transceiver subsystems. It has a role in shifting the signal frequency for more convenient processing of up-conversion as well as down-conversion. Despite generating the desired signal, the mixer also generates spurious noise that wastes power and reduces the performance of the overall system.

Crude Drugs for Clearing Heat Contain Compounds Exhibiting Anti-Inflammatory Effects in Interleukin-1β-Treated Rat Hepatocytes.

Traditional Japanese medicines, i.e., Kampo medicines, consist of crude drugs (mostly plants) that have empirical pharmacological functions ('' in Japanese), such as clearing heat.

Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential.

Malaria, caused by species and transmitted by mosquitoes, continues to pose a significant global health threat. Pipecolisporin, a cyclic hexapeptide isolated from , has emerged as a promising antimalarial candidate due to its potent biological activity and stability. This study explores the synthesis, antimalarial activity, and computational studies of pipecolisporin, aiming to better understand its therapeutic potential.

A Review on the Nomenclature and Taxonomy of the Old World Thread-Legged Bug Genus (Hemiptera: Reduviidae: Emesinae).

The nomenclatural and taxonomic issues regarding the thread-legged bug genera Kirkaldy, 1901 and Bergroth, 1903 are reviewed, and is concluded to be the valid name of the genus. A comprehensive review of is conducted, resulting in 18 new combinations and two new synonymies [ (Villiers, 1970) , (Ghate, Boyane & Joshi, 2019) , (Bergroth, 1903) , (McAtee & Malloch, 1926) , (Paiva, 1919) , (Lhoste, 1939) = Miller, 1956 , (Kulkarni & Ghate, 2016) , (Ribes, 1987) , (Lhoste, 1939) , (McAtee & Malloch, 1926) , (Villiers, 1972) , (Wygodzinsky, 1966) , (Wygodzinsky, 1966) , (Distant, 1906) , (Villiers, 1970) , (Horváth, 1910) , (Villiers, 1949) = Miller, 1954 , and (Rédei, 2005) ]. The bibliographies, diagnosis, and known distribution records are presented for all described species, and three new species [ (from Yunnan, China), (from Sabah, Malaysia), and (from Sulawesi, Indonesia)] are described.

Asthma Risk Prevalence and Associated Factors in Stunted Children: A Study Using Asthma Predictive Index.

: The prevalence of stunted children under 5 years in Indonesia is relatively high. Stunting is a significant risk factor for wheezing disorders. The asthma predictive index (API) identifies children with a recurrent wheezing disorder at risk of developing asthma during the first 3 years.

Sources and Transmission Routes of Carbapenem-Resistant : Study Design and Methodology of the SAMPAN Study.

: The global spread of carbapenem-resistant (CRPA) warrants collaborative action. Guidance should come from integrated One Health surveillance; however, a surveillance strategy is currently unavailable due to insufficient knowledge on the sources and transmission routes of CRPA. The aim of the SAMPAN study ("A Smart Surveillance Strategy for Carbapenem-resistant ") is to develop a globally applicable surveillance strategy.

Antibacterial Efficacy Comparison of Electrolytic and Reductive Silver Nanoparticles Against .

The aim of this study was to develop an electrolysis system to produce silver nanoparticles free from toxic gases, as the most common reduction and electrolysis techniques produce nitrogen dioxide (NO) as a byproduct, which is harmful to human health. The new electrolysis system used two identical silver plate electrodes, replacing silver and carbon rods, and used water as the electrolyte instead of silver nitrate (AgNO) solution since AgNO is the source of NO. The electrolytic silver nanoparticles (ESNs) produced by the new system were characterized and compared with reductive silver nanoparticles (RSNs).

Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population.

(1) Background: This study is designed to establish thyroid-stimulating hormone (TSH) reference intervals tailored to different neonatal age groups and Indonesian local populations. (2) Methods: Dried blood spot neonatal TSH values, from 1 January 2022 to 31 December 2023, were used to establish the neonatal TSH reference intervals partitioned by sex, gestational age, and ethnic group at different neonatal ages. (3) Results: A significant difference in the reference intervals value was observed in sex, gestational ages, and parental ethnicity groups in different neonatal age subgroups ( < 0.

The Association of Vitamin D, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell-Derived Neurotrophic Factor (GDNF) with Development in Children.

Background: Short stature remains a global problem and is associated with vitamin D status. Vitamin D is also a neurosteroid with regard to neurotrophic factors but its role in development is unclear. Therefore, this study analyzed the relationships between vitamin D, NGF, GDNF, and BDNF and developmental status in children with a history of short stature (<2 years).