380 results match your criteria: "IMS and SUM Hospital[Affiliation]"

Article Synopsis
  • Flatbush diabetes is an emerging and significant type of diabetes that is gaining attention worldwide, often confused with type 1 diabetes due to similar symptoms.
  • It's important to recognize the differences between Flatbush diabetes, type 1, and type 2 diabetes for better early diagnosis and treatment strategies.
  • A rare case study highlighted a young male experiencing recurrent diabetic ketoacidosis (DKA) during febrile illnesses, underscoring the need for more awareness and research on Flatbush diabetes.
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As genetic testing becomes increasingly accessible and affordable, the uniform and accurate interpretation of genetic variants becomes essential. The ACMG/AMP joint guidelines provide the basis for systematic and uniform interpretation of pathogenicity of genetic variants. However, the application of these in routine clinical interpretation at-scale has largely been limited by the lack of resources providing harmonized data especially at a population-scale.

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Introduction: Aneurysmal bone cyst (ABC) is a benign, expansile hemorrhagic tumor usually presenting in the metaphyseal region of long bones. Diaphyseal ABCs are rare and prone to pathological fracture and increased morbidity. Treatment options are centered around the site and size of the lesion.

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Background: This study intended to assess the quality of life (QOL) with telephonic interview using the Short Form 12 (SF-12) Scale in follow-up patients admitted to the intensive care unit (ICU) with COVID-19 pneumonia.

Methods: This prospective, noninterventional follow-up study was conducted at a tertiary care center. COVID-19 pneumonia patients discharged from ICU were recruited for telephonic interviews.

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Scrub typhus continues to pose a significant threat to life, manifesting in a spectrum that ranges from mild, non-specific febrile illness to severe multi-organ dysfunction. Although neuropsychiatric symptoms are rare in cases of scrub typhus, we present a unique case involving a 60-year-old male who initially exhibited fever and headache, subsequently developing neuropsychiatric symptoms on the third day of hospitalization. Following the exclusion of prevalent metabolic, autoimmune, and infectious conditions, he was diagnosed with hypoactive delirium associated with scrub typhus.

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Oral squamous cell carcinoma (OSCC) is a disease of significant concern with higher mortality rates. Conventional treatment approaches have several drawbacks, leading to the opening of new research avenues in the field of nanoparticle-based cancer therapeutics. The study aimed at the synthesis of gold nanoparticles (Pm-AuNPs) from the aqueous bark extract of , followed by its characterization and anticancer evaluation against OSCC.

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Spilanthes paniculata, a member of the Asteraceae family, is predominantly used as a traditional remedy in addressing oral ailments, particularly gum infections and sore throat. The flowers are chewed to alleviate toothache immediately. This study evaluated a comparison between the essential oils of leaf and flower derived from Spilanthes paniculata targeting the SCC9 oral cell lines using in vitro and in silico approaches.

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Article Synopsis
  • * The study focused on colistin-resistant, carbapenemase-producing Klebsiella pneumoniae found in the Kathajodi river, identifying multiple resistance genes and the potential for these bacteria to cause serious infections.
  • * Isolates showed extensive drug resistance and virulence factors, raising alarms about their spread and potential outbreaks; the research highlights the need for improved waste management to prevent resistant strains from entering the environment.
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  • - Compound volvulus, or ileosigmoid knotting, is a rare yet serious condition that causes intestinal obstruction by twisting a section of the small intestine, disrupting blood flow and requiring immediate surgical intervention.
  • - Diagnostic imaging like CT scans or MRIs is more effective than X-rays in differentiating ileosigmoid knotting from other intestinal blockages, highlighting the necessity for precise diagnosis in urgent cases.
  • - The case of a 45-year-old male patient presenting with severe abdominal pain, vomiting, and signs of dehydration emphasizes the urgent need for surgical evaluation, as symptoms may indicate acute bowel obstruction due to this condition.
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Article Synopsis
  • Therapeutic plasma exchange (TPE) is a medical procedure that separates plasma from blood cells to treat conditions caused by immune system issues by removing harmful substances like antibodies and toxins.
  • The study analyzed medical records of 118 patients who underwent TPE for neurological disorders, focusing on the effectiveness, complications, and reasons for incomplete cycles of TPE.
  • Results showed that GBS was the most common reason for TPE, with 57.6% of patients completing all sessions; however, issues like vascular access blockage and mild complications such as cramps were noted.
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In recent times, there has been a notable surge in the investigation of new antibiotic substances derived from natural origins. Pleurotus eous is an edible mushroom that has various useful bioactive substances and therapeutic properties, including antimicrobial activity. The present study aims to evaluate the antimicrobial efficacy of the methanolic extract of P.

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Aim And Background: Neutrophil CD64 (nCD64) is evolving as a prognostic biomarker in sepsis. The primary objective of this study was to evaluate whether serial trend of nCD64, procalcitonin (PCT), and C-reactive protein (CRP) predict 28-day mortality in patients with sepsis/septic shock, as per Sepsis-3 criteria.

Materials And Methods: This prospective, observational single-center cohort study included 60 adult patients (age ≥18 years) with sepsis.

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Article Synopsis
  • Floating hip injuries, characterized by a combination of hip dislocation and fractures, are rare and challenging to treat, often resulting in poor outcomes.
  • A case study of a 35-year-old man showed successful management of his hip and femur fractures using a combination of external fixation and surgical techniques, leading to gradual recovery.
  • The conclusion emphasizes that careful staged management can improve outcomes and minimize complications in patients with complex floating hip injuries.
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Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable.

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Psoriasis is a common chronic, immune-mediated inflammatory skin disease associated with various comorbidities. Managing psoriasis is often challenging as the therapy is decided based on the area of the disease, associated comorbidities and impairment in quality of life, besides the patient's preference. Making progress in the development of new molecules that can be used topically or orally, effectively controlling the disease with minimal side effects and providing long-lasting remissions are the needs of the hour.

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Psoriasis is a chronic and complex immune-mediated papulosquamous disease affecting almost 2% of the world population. The interaction between a genetically predisposed individual and environmental triggers leads to a vicious cycle involving autoreactive T cells, dendritic cells, keratinocytes and dermal cells. Up to 40% of the psoriasis cases develop disabling psoriatic arthritis and an equal number of patients also tend to develop metabolic syndrome as well as cardiovascular comorbidities; hence, this is no more considered to be a disease limited to skin only.

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Traumatic penetrating spinal injuries with wooden objects are rare. A 6-year-old boy presented with history of fall from tree 1 month back. It resulted in a penetrating injury at the lumbosacral area, followed by a discharging sinus without any neurological deficit.

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Article Synopsis
  • - Toilet seat dermatitis (TSD) affects children, mainly on the buttocks and thighs, and is linked to allergens in toilet seats or irritants like detergents, previously thought to be solely due to wood allergies.
  • - In a study of six children diagnosed with atopic dermatitis, patch tests for allergens showed negative results, leading to successful management with topical steroids, tacrolimus, and advice on using toilet seat covers.
  • - The study indicates that contact dermatitis can resolve with proper treatment and toilet seat avoidance, while also highlighting the need for further research due to its small sample size and complex relationship with atopy.
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Pyrazinamide-induced Toxic Epidermal Necrolysis.

Ann Afr Med

July 2024

Department of Dermatology, IMS and Sum Hospital, Bhubaneswar, Odisha, India.

The antitubercular drugs are associated with different cutaneous adverse drug reactions. Toxic epidermal necrolysis (TEN) is a severe form of cutaneous reaction. Although it is rare, it carries a high mortality rate.

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Article Synopsis
  • MAFLD (Metabolic Dysfunction-Associated Fatty Liver Disease) is becoming more common, and it can lead to serious liver problems called MAFLD-ACLF, but what affects patient recovery isn't fully known yet.
  • In a study, researchers looked at data from patients with MAFLD-ACLF to understand their health conditions and see who survived after 90 days, finding that about 51% of patients did survive.
  • They discovered new scoring systems to better predict survival, which included factors like diabetes and the causes of liver damage, and these new scores worked better than older ones.
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