5 results match your criteria: "IMIM-Hospital del Mar Institute of Medical Research[Affiliation]"
Impact of prehabilitation during neoadjuvant chemotherapy and interval cytoreductive surgery on ovarian cancer patients: a pilot study.
World J Surg Oncol
February 2022
Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Passeig Marítim 25-29, E-08003, Barcelona, Spain.
Background: Cytoreductive surgery followed by systemic chemotherapy is the standard of treatment in advanced ovarian cancer where feasible. Neoadjuvant chemotherapy (NACT) followed by surgery is applicable where upfront cytoreductive surgery is not feasible because of few certain reasons. Nevertheless, surgical interventions and the chemotherapy itself may be associated with postoperative complications usually entailing slow postoperative recovery.
View Article and Find Full Text PDFSkin sensitization in silico protocol.
Regul Toxicol Pharmacol
October 2020
Leadscope, Inc, 1393 Dublin Rd, Columbus, OH, 43215, USA.
The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the strengths of in silico methods to support a weight of evidence assessment without conducting a test in animals. While in silico methods vary greatly in their purpose and format; there is a need to standardize the underlying principles on which such models are developed and to make transparent the implications for the uncertainty in the overall assessment. In this contribution, the relationship between skin sensitization relevant effects, mechanisms, and endpoints are built into a hazard assessment framework.
View Article and Find Full Text PDFImpact of monitoring health-related quality of life in clinical practice in children with type 1 diabetes mellitus.
Qual Life Res
December 2017
Health Services Research Unit, IMIM-Hospital del Mar Institute of Medical Research, Barcelona Biomedical Research Park (office 138.03), Dr Aiguader 88, 08003, Barcelona, Spain.
Purpose: To test whether the systematic monitoring of health-related quality of life (HRQOL) in clinical practice in Spanish pediatric patients with T1DM helps improve their daily life in a multicenter longitudinal study.
Methods: One hundred thirty-six patients participated, recruited from five centers in Barcelona, Spain (72 girls, mean age 13.4 years).
Health-related quality of life (HRQOL) and its associated factors in children with Type 1 Diabetes Mellitus (T1DM).
BMC Pediatr
January 2017
Catalan Agency for Health Quality and Assessment, Roc Boronat 81-95, 08005, Barcelona, Spain.
Background: The objective of the study was to describe the baseline health-related quality of life (HRQOL) in a cohort of children and adolescents with type 1 diabetes mellitus (T1DM), and analyze its associated clinical and sociodemographic factors, assessing HRQOL through internet.
Methods: This was a descriptive study of 136 patients with T1DM from 5 hospitals in Catalonia, Spain (72 girls, mean age 13.4 years (range 8-19).
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
PLoS Pathog
July 2016
Medicines for Malaria Venture, Geneva, Switzerland.
Article Synopsis
- - The lack of collaboration between academia and the pharmaceutical industry limits new drug discovery, but open source drug initiatives, like sharing physical compounds, could help bridge this gap and accelerate research.
- - The Medicines for Malaria Venture created the Malaria Box, a collection of over 400 compounds tested against malaria, which has been shared with almost 200 research groups, encouraging public data sharing on screening results.
- - Recent findings from the Malaria Box screenings revealed mechanisms of action for many compounds against various life stages of the malaria parasite, and some showed effectiveness against other pathogens and cancer cell lines, providing valuable data for further drug development.