28 results match your criteria: "IL J.P.B.; and Wadsworth Center[Affiliation]"
Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Patients With Mild Stroke in the Third International Stroke Trial-3: Post Hoc Analysis.
Stroke
August 2015
From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (P.K., J.P.B.); Genentech, Inc, South San Francisco, CA (D.T.); Division of Clinical Neurosciences (G.C., P.S.), and Division of Neuroimaging Sciences (J.M.W.), University of Edinburgh, Edinburgh, Scotland; Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia (R.I.L.); and Department of Public Health Sciences, Medical University of South Carolina, Charleston (S.D.Y.).
Background And Purpose: Randomized trial evidence on the risk/benefit ratio of thrombolysis for mild stroke is limited. We sought to determine the efficacy of intravenous recombinant tissue-type plasminogen activator (IV r-tPA) in a subset of patients with mild deficit in the third International Stroke Trial (IST-3).
Methods: IST-3 compared IV r-tPA with control within 6 hours of onset in patients for whom IV r-tPA was considered promising but unproven.
Follicular fluid concentrations of lipids and their metabolites are associated with intraovarian gonadotropin-stimulated androgen production in women undergoing in vitro fertilization.
J Clin Endocrinol Metab
May 2015
Division of Endocrinology (A.G., M.-C.B., J.-P.B.), Department of Medicine, and Department of Obstetrics and Gynecology (B.C.-M.), Université de Sherbrooke, and Centre de Recherche Clinique Étienne-LeBel (B.C.-M., J.-P.B.), Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4; and PROCREA Cliniques (B.C.-M.), Mt Royal, Québec, Canada H3P 2W3.
Context: Although growing evidence points toward a role of lipotoxicity in the development of hyperandrogenesis, the main feature of polycystic ovary syndrome, few studies directly assessed this association in vivo in humans, and none targeted the ovarian milieu.
Objective: The main objective of this study was to correlate follicular fluid (FF) T levels with lipids, lipid metabolites, and inflammation markers.
Design: This was a cross-sectional study.
Metabolic and adipose tissue signatures in adults with Prader-Willi syndrome: a model of extreme adiposity.
J Clin Endocrinol Metab
March 2015
INSERM, U1166, Nutriomic team 6 (D.L., H.H., V.P., C.R., B.D., K.C., C.P.), Sorbonne Universities (D.L., H.H., V.P., C.R., B.D., K.C., C.P.), University Pierre et Marie Curie-Paris 6, Unité Mixte de Recherche en Santé Unité 1166, and Institute of Cardiometabolism and Nutrition (ICAN) (S.M., M.C., P.F., K.C., C.P.), Assistance Publique Hôpitaux de Paris, Department of Nutrition, and French Reference Centre for Prader-Willi Syndrome, Pitié-Salpêtrière Hospital, Paris, F-75013 France; Functional Unit of Inflammatory and Metabolic Biomarkers (J.-P.B.), Department of Biochemistry and Hormonology, Tenon Hospital, Assistance Publique des Hôpitaux de Paris, F-75970 Paris, France; Bioinformatics Platform (N.C.), Plateforme de Bioinformatique, SFR Necker, University Paris V, F-75015 Paris, France; and Department of Pediatric Nutrition and Gastroenterology (B.D.), Trousseau Hospital, Assistance Publique Hôpitaux de Paris, F-37044 Paris, France.
Context: Prader-Willi syndrome (PWS), the most frequent syndrome of obesity, is a model of early fat mass (FM) development, but scarce data exist on adipose tissue characteristics.
Objective: The objective of the study was to compare metabolic, fat distribution, and transcriptomic signatures of sc adipose tissue (scAT) in PWS adults, with matched obese adults with primary obesities.
Main Outcomes And Measures: Hormonal and metabolic assessments, systemic inflammation, and gene expression in scAT were compared between PWS patients and obese controls (OCs).