11 results match your criteria: "IL (A.H.K.); and University of Rochester[Affiliation]"
Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2.
mBio
October 2024
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Unlabelled: The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes of patients with COVID-19, but the mechanism and consequences of inflammasome activation require further investigation.
View Article and Find Full Text PDFTrends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities.
Blood Adv
July 2024
Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
Article Synopsis
- There has been an increase in the number of hematopoietic cell transplants (HCT) and improvement in overall survival after these procedures for blood disorders, but the impact on racial/ethnic minorities is unclear.
- A study examined transplant rates and survival trends among non-Hispanic Whites, non-Hispanic African Americans, and Hispanics from 2009 to 2018, revealing that Hispanics and non-Hispanic African Americans experienced higher rates of transplant than non-Hispanic Whites.
- Despite overall improvements in survival rates across groups, non-Hispanic African Americans faced greater mortality risks after allogeneic transplants, indicating ongoing disparities that need to be addressed.
Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy.
Proc Natl Acad Sci U S A
February 2024
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Integrating multimodal neuro- and nanotechnology-enabled precision immunotherapies with extant systemic immunotherapies may finally provide a significant breakthrough for combatting glioblastoma (GBM). The potency of this approach lies in its ability to train the immune system to efficiently identify and eradicate cancer cells, thereby creating anti-tumor immune memory while minimizing multi-mechanistic immune suppression. A critical aspect of these therapies is the controlled, spatiotemporal delivery of structurally defined nanotherapeutics into the GBM tumor microenvironment (TME).
View Article and Find Full Text PDFChanges in cardiac troponins during hemodialysis depend on hemodialysis membrane and modality: a randomized crossover trial.
Clin Kidney J
January 2024
Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke.
Hypertension
March 2024
Second Department of Neurology, Attikon University Hospital, School of Medicine (L.P., G.T.), National and Kapodistrian University of Athens, Greece.
Background: Data on systolic blood pressure (SBP) trajectories in the first 24 hours after endovascular thrombectomy (EVT) in acute ischemic stroke are limited. We sought to identify these trajectories and their relationship to outcomes.
Methods: We combined individual-level data from 5 studies of patients with acute ischemic stroke who underwent EVT and had individual blood pressure values after the end of the procedure.
Update on MRI in Evaluation and Treatment of Endometrial Cancer.
Radiographics
November 2022
From the Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213 (E.M.); Department of Abdominal Imaging, Montpellier Cancer Research Institute (IRCM), Montpellier, France (S.N.); Department of Radiology, University of Michigan, Ann Arbor, Mich (E.B.S., K.E.M.); Department of Abdominal Imaging, Division of Diagnostic Imaging (G.M.R., A.M.V.), Department of Imaging Physics (K.P.H., R.J.S.), Department of Radiation Oncology (A.H.K.), and Department of Gynecologic Oncology and Reproductive Medicine (P.T.S.), University of Texas MD Anderson Cancer Center, Houston, Tex; Department of Radiology, Imperial College, London, United Kingdom (A.G.R.); Department of Diagnostic Radiology, Massachusetts General Hospital, Boston, Mass (S.I.L.); and Department of Radiology, University of Wisconsin-Madison, Madison, Wis (E.A.S.).
Endometrial cancer is the second most common gynecologic cancer worldwide and the most common gynecologic cancer in the United States, with an increasing incidence in high-income countries. Although the International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer is a surgical staging system, contemporary published evidence-based data and expert opinions recommend MRI for treatment planning as it provides critical diagnostic information on tumor size and depth, extent of myometrial and cervical invasion, extrauterine extent, and lymph node status, all of which are essential in choosing the most appropriate therapy. Multiparametric MRI using a combination of T2-weighted sequences, diffusion-weighted imaging, and multiphase contrast-enhanced imaging is the mainstay for imaging assessment of endometrial cancer.
View Article and Find Full Text PDFLongitudinal Humoral and Cellular Immune Responses Following SARS-CoV-2 Vaccination in Patients with Myeloid and Lymphoid Neoplasms Compared to a Reference Cohort: Results of a Prospective Trial of the East German Study Group for Hematology and Oncology (OSHO).
Cancers (Basel)
March 2022
Krukenberg Cancer Center Halle, University Hospital Halle (Saale), 06120 Halle (Saale), Germany.
Article Synopsis
- The study investigates the immune responses of patients with blood cancers receiving checkpoint-inhibitors after vaccination against SARS-CoV-2, comparing their outcomes with those of healthy controls.
- Results showed that while initial seroconversion (antibody response) was lower in patients (68%) compared to controls (98%), there was a significant improvement by day 120 across all patient groups, particularly for those on checkpoint-inhibitors.
- The research highlights that despite some patients showing T-cell responses, there was no clear link between antibody levels and T-cell responses, suggesting that evaluating both immune responses is important for understanding patient immunity and guiding public health vaccination strategies.
Herpesviruses and Inflammasomes: One Sensor Does Not Fit All.
mBio
February 2022
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Herpesviruses are ubiquitous double-stranded DNA viruses that cause lifelong infections and are associated with a variety of diseases. While they have evolved multiple mechanisms to evade the immune system, they are all recognized by the innate immune system, which can lead to both localized and systemic inflammation. A more recently appreciated mechanism of herpesvirus innate immune activation is through inflammasome signaling.
View Article and Find Full Text PDFSurvival benefit of the primary prevention implantable cardioverter-defibrillator among older patients: does age matter? An analysis of pooled data from 5 clinical trials.
Circ Cardiovasc Qual Outcomes
March 2015
From the Duke Clinical Research Institute, Durham, NC (P.L.H., S.M.A., R.E., K.L.L., D.B.M., G.S.); University of Washington, Seattle (J.Y.H., G.H.B., A.H., P.J.K., L.Y.T.I.); Columbia University, New York, NY (J.T.B., R.S.); Beth Israel Deaconess Medical Center, Boston, MA (A.B.); I.R.C.C.S. Policlinico San Donato, Milan, Italy (R.C.); University of Toronto, Ontario, Canada (P.D.); Northwestern Feinberg School of Medicine, Chicago, IL (A.H.K.); and University of Rochester, Rochester, NY (A.J.M.).
Article Synopsis
- The study merged data from 5 major trials to assess how patient age impacts death and rehospitalization risks after receiving an implantable cardioverter-defibrillator (ICD).
- Older patients had more health issues compared to younger patients, but ICD recipients had a lower risk of death across all age groups, with varying levels of benefit as age increased.
- The findings indicate that while ICDs provide survival benefits, this effectiveness diminishes with age, and there was no significant relationship between age and rehospitalization rates.
Fibrinolysis for intraventricular hemorrhage: an updated meta-analysis and systematic review of the literature.
Stroke
September 2014
From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.).
Background And Purpose: Intraventricular hemorrhage is associated with high mortality and poor functional outcome. The use of intraventricular fibrinolytic (IVF) therapy as an intervention in intraventricular hemorrhage is an evolving therapy with conflicting reports in the literature. The goal of this study is to investigate the impact of IVF on mortality, functional outcome, ventriculitis, shunt dependence, and rehemorrhage.
View Article and Find Full Text PDFRisk stratification for sudden cardiac death: a plan for the future.
Circulation
January 2014
Department of Medicine-Cardiology (J.J.G., A.H.K., R.P.), Department of Preventive Medicine (D.L.-J., R.P.), and Weinberg College of Arts and Sciences and Medical Humanities and Bioethics (L.Z.), Northwestern University, Chicago, IL; Department of Health Services and Pharmacy, University of Washington, Seattle (A.B.); National Institutes of Health, Washington DC (R.B.); Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (A.E.B.); Department of Medicine, University at Buffalo, The State University of New York, Buffalo (M.E.C., J.M.C.); Krannert Institute of Cardiology, Indiana University, Indianapolis (P.-S.C., D.P.Z.); Cardiac Electrophysiology Research, Cedars-Sinai Medical Center, Los Angeles, CA (S.S.C.); Summa Health System Cardiovascular Institute, Cleveland, OH (O.C.); CON-ECT Clinical Coordinating Centre, Calgary, Alberta, Canada (D.V.E.); Department of Medicine, University of California, San Francisco (B.L., J.E.O.); Department of Medicine (A.J.M.), and Department of Medicine Cardiology (W.Z.), University of Rochester Medical Center, Rochester, NY; Department of Medicine, University of Miami Health System, Miami, FL (R.J.M.); Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (W.G.S.); and Department of Medicine, The Johns Hopkins University Baltimore, MD (G.F.T.).