Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting type II NADH dehydrogenase.

() type II NADH dehydrogenase (NDH-2) transports electrons into the mycobacterial respiratory pathway at the cost of reduction of NADH to NAD and is an attractive drug target. Herein, we have synthesised a series of 2-mercaptobenzothiazoles (C1-C14) and evaluated their anti-tubercular potential as NDH-2 inhibitors. The synthesised compounds C1-C14 were evaluated for MIC and ATP depletion against H37Ra, , and H37Rv mc 6230.

Cytochrome oxidase: an emerging anti-tubercular drug target.

Cytochrome (cyt-) oxidase, one of the two terminal oxidases in the () oxidative phosphorylation pathway, plays an indispensable role in maintaining the functionality of the metabolic pathway under stressful conditions. However, the absence of this oxidase in eukaryotic cells allows researchers to select it as a potential drug target for the synthesis of anti-tubercular (anti-TB) molecules. Cyt- inhibitors have often been combined with cytochrome / super-complex inhibitors in anti-TB drug regimens to achieve a desired bactericidal response.