6 results match your criteria: "IIS La Fe Health Research Institute[Affiliation]"
Multidrug-resistant bacterial infections after liver transplantation: Prevalence, impact, and risk factors.
J Hepatol
June 2024
Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid. Universidad de Alcalá, Madrid, España; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto Salud Carlos III, Madrid, España. Electronic address:
Background & Aims: Infections by multidrug-resistant bacteria (MDRB) are an increasing healthcare problem worldwide. This study analyzes the incidence, burden, and risk factors associated with MDRB infections after liver transplant(ation) (LT).
Methods: This retrospective, multicenter cohort study included adult patients who underwent LT between January 2017 and January 2020.
The Use of Non-Apoptotic Sperm Selected by Magnetic Activated Cell Sorting (MACS) to Enhance Reproductive Outcomes: What the Evidence Says.
Biology (Basel)
January 2024
IVIRMA Global Research Alliance, IVI Foundation, Andrology and Male Infertility Research Group, IIS La Fe Health Research Institute, Av. Fernando Abril Martorell, 106. Tower A, 1st Floor, 46026 Valencia, Spain.
Article Synopsis
- Sperm selection using the MACS (Magnetic Activated Cell Sorting) method aims to improve reproductive outcomes by isolating non-apoptotic, healthier sperm from an ejaculate.
- The review highlights inconsistencies in existing studies regarding MACS, pointing out potential issues such as poor study quality and flawed methodologies that undermine the findings.
- Overall, the evidence for the benefits of MACS remains inconclusive, indicating a need for more rigorous research before it can be routinely recommended in clinical practice.
Erratum to 'Cumulative live birth rates in ICSI cycles with donated oocytes are not improved by magnetic-activated cell sorting: A retrospective study in unselected males' [Reproductive BioMedicine Journal 44/4 (2022) 677-684].
Reprod Biomed Online
December 2023
IVI Foundation - IIS La Fe Health Research Institute, Av. Fernando Abril Martorell, 106. Torre A, Planta 1ª, Valencia. 46026, Spain.
Antioxidant Supplementation Alleviates Mercury-Induced Cytotoxicity and Restores the Implantation-Related Functions of Primary Human Endometrial Cells.
Int J Mol Sci
May 2023
Reproductive Medicine Research Group, IVI Foundation-IIS La Fe Health Research Institute, 46026 Valencia, Spain.
Mercury (Hg) cytotoxicity, which is largely mediated through oxidative stress (OS), can be relieved with antioxidants. Thus, we aimed to study the effects of Hg alone or in combination with 5 nM N-Acetyl-L-cysteine (NAC) on the primary endometrial cells' viability and function. Primary human endometrial epithelial cells (hEnEC) and stromal cells (hEnSC) were isolated from 44 endometrial biopsies obtained from healthy donors.
View Article and Find Full Text PDFCumulative live birth rates in donor oocyte ICSI cycles are not improved by magnetic-activated cell sorting sperm selection.
Reprod Biomed Online
April 2022
IVI Foundation - IIS La Fe Health Research Institute, Av. Fernando Abril Martorell, 106. Torre A, Planta 1ª, Valencia . 46026, Spain.
Research Question: Does magnetic-activated cell sorting (MACS) for sperm selection increase cumulative live birth rates (CLBR) or improve clinical parameters of reproductive success in couples undergoing intracytoplasmic sperm injection (ICSI) with donor oocytes?
Design: Retrospective multicentre observational study including data compiled from unselected couples who underwent ICSI cycles with donated oocytes in 15 Spanish IVIRMA fertility clinics (January 2008 to February 2020). Patients were divided into reference (standard semen processing, n = 40,157) and MACS (additional sperm selection step by MACS, n = 1,240) groups. CLBR were plotted on Kaplan-Meier curves and compared using the Mantel-Cox test.
Sperm Selection by Magnetic-Activated Cell Sorting before Microinjection of Autologous Oocytes Increases Cumulative Live Birth Rates with Limited Clinical Impact: A Retrospective Study in Unselected Males.
Biology (Basel)
May 2021
Andrology and Male Infertility Research Group, IVI Foundation-IIS La Fe Health Research Institute, Av. Fernando Abril Martorell, 106. Tower A, 1st Floor, 46026 Valencia, Spain.
The application of MACS non-apoptotic sperm selection in infertility clinics is controversial since the published literature does not agree on its effect on reproductive outcomes. Therefore, it is not part of the routine clinical practice. Classical measures of reproductive success (pregnancy or live birth rates per ovarian stimulation) introduce a bias in the evaluation of a technique's effect, since only the best embryo is transferred.
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