Antiplasmodial Activity of Probiotic YZ01 in ANKA Infected BALB/c Mice.

Malaria remains a significant global health challenge, with the deadliest infections caused by . In light of the escalating drug resistance and the limited effectiveness of available vaccines, innovative treatment approaches are urgently needed. This study explores the potential of the probiotic YZ01, isolated from traditionally fermented kindirmo milk, to modify host responses to ANKA infection.

Low prevalence of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions in malaria-endemic states of India.

Rapid diagnostic tests (RDTs) are crucial for diagnosing malaria in resource-limited settings. These tests, which detect the histidine-rich protein 2 (PfHRP2) and its structural homologue PfHRP3, are specifically designed to identify Plasmodium falciparum. Deletion of the Pfhrp2 gene in parasite has been reported in India and other malaria-endemic countries.

Cross-sectional Assessment of Body Image Perception, Image Satisfaction, Body Image Discrepancy and Dietary Habits in Medical Students of Ujjain.

Background: Being judgmental about self-body image and satisfaction or dissatisfaction with one's own body is a natural phenomenon. If perceived incorrectly can lead to dissatisfaction and negative social, emotional, psychological and physical consequences.

Methods: A cross-sectional study was planned and the data was collected with the help of a semi-structured proforma.

Assessment of the quality of malaria surveillance and laboratory services for diagnosis in three districts of Gujarat state, India.

Objectives: Surveillance is the backbone for the control of malaria and its elimination. In the state of Gujarat, situated in the western region of India, some of the districts reported a high annual blood examination rate (ABER) for malaria. Therefore, a study was conducted to identify the underlying reasons for the increase in the ABER for malaria.

One-Step Multiplex Polymerase Chain Reaction Assay for the Detection of Major Disease-Transmitting Mosquito Vectors in India.

Mosquitoes are important vectors that transmit viral, protozoan, and helminthic diseases across the world. Climate change and unplanned urbanization are accelerating the spread of these diseases. Controlling vector-borne diseases can be performed most effectively through vector control.

Heat Shock Proteins expression in malaria and dengue vector.

The survival of mosquitoes under changing climatic conditions particularly temperature, is known to be supported by Heat Shock Proteins (HSPs). In view of climate change, it is imperative to know whether the mosquito vectors will be able to withstand the increased temperatures or perish. Therefore, the present study was undertaken on the expression of HSPs' gene in An.

An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR, and Commercialized Medications.

Filariasis is one of the oldest, most dangerous, debilitating, disfiguring diseases and often ignores tropical disorders. It presents with a range of clinical symptoms, a low death rate, and a high morbidity rate, which contributes to social discrimination. This condition has major effects on people's socioeconomic circumstances.

Unravelling the Influence of Host Genetic Factors on Malaria Susceptibility in Asian Populations.

Malaria is a deadly blood-borne disease caused by a Plasmodium parasite. Infection results in various forms of malaria, including an asymptomatic state, uncomplicated disease, or severe disease. Severe malaria (SM) is particularly prevalent among young children and is a significant cause of mortality.

Microhaplotypes: the QR-code for Plasmodium vivax infection dynamics.

An array of microhaplotypes - small segments of ≤200 nucleotides with heterozygous multiple-SNP exhibiting multiple allelic combinations - were identified in the Plasmodium vivax genome by Siegel et al. Interestingly, the microhaplotype has significant potential to distinguish relapse/reinfection and identify genetic relatedness across vivax-endemic areas. It is essential to validate the universal applicability of microhaplotypes.

Screening Clinical, Laboratory and Host Markers for Diagnosis of Disease Severity in Clinical Samples.

Unlabelled: Malaria is one of the most infectious disease that affects lives of million people throughout the world. Recently, there are several reports which indicate causing severe disease in infected patients from different parts of the world. For disease severity, the data related to immunological and inflammatory status in human host is very limited.

Reply to correspondence by Deora et al. in Human Genomics 18, article no.: 52 (2024): critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID‑19 severity in Indian population: a novel finding".

A reply to the correspondence by Deora et al.- Critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID‑19 severity in Indian population: a novel finding". The reply contains point-wise rebuttal to the concerns, particularly addressing the epidemiological, statistical, and mathematical issues raised by Deora et al.

A cub and sushi domain-containing protein with esterase-like activity confers insecticide resistance in the Indian malaria vector Anopheles stephensi.

Chemical insecticides (organophosphates and pyrethroids) in the form of IRS (Indoor Residual Sprays) and LLINs (Long Lasting Insecticidal Nets) are the cornerstone for vector control, globally. However, their incessant use has resulted in widespread development of resistance in mosquito vectors, warranting continuous monitoring and investigation of the underlying mechanisms of resistance. Here, we identified a previously uncharacterized- Cub and Sushi Domain containing Insecticide Resistance (CSDIR) protein and generated evidence for its role in mediating insecticide resistance in the Anopheles stephensi.

Anopheles jamesii Supports Plasmodium vivax Sporogony under Laboratory Conditions.

Anopheles jamesii, considered to be a non-malaria vector, is an abundant mosquito species found in coastal India and several countries in Asia. In Goa, western India, An. jamesii is the dominant anopheline species by numbers, and in recent epidemiological surveys, they have tested positive for Plasmodium carriage.

Risk of Neglected Zoonotic Malaria in Western Ghats: How the Ecosystem Favors Transmission of an Impending Public Health Threat.

The threat of zoonotic malaria remains largely overlooked in India, particularly in regions such as the Western Ghats (WG), a biodiversity hotspot. The WG has diverse species of non-human primates that serve as reservoir hosts for simian malaria parasites. The presence of the Leucosphyrus group of mosquitoes and other vectors of human malaria makes WG vulnerable to the risk of parasite spillover.

Moving population is a challenge for malaria elimination in India: A cross-sectional study to assess malaria parasite infections in walking pilgrims in western Rajasthan, India.

Objectives: India is vigorously pursuing malaria elimination by 2030 and one of the key challenges is how to prevent the malaria risk associated with long-distance migrations of populations from endemic to non-endemic areas. Millions of pilgrims walking to the holy Ramdevra temple stay in temporary shelters along the route in district of Jaisalmer, Rajasthan state in western India. The main pilgrimage period coincides with the post-monsoon period with elevated vector densities.

Glucose-6-phosphate Dehydrogenase Variants: Analysing in Indian Plasmodium vivax Patients.

Purpose: Primaquine (PQ) is recommended for radical cure of Plasmodium vivax (Pv) malaria, but its utilization is still limited due to high risk of severe haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD-d). The aim of the present study is to assess the different genotypic variants leading to G6PD-d in Delhi and Goa regions of India.

Methods: A total of 46 samples (34 retrospective Pv-mono-infected samples and 12 Pv-uninfected samples) were included in the study.

Geographical and temporal dynamics of genetic diversity of merozoite surface proteins 1/2 in India.

Unlabelled: The high genetic diversity of () is a big obstacle to successful vaccine development programs. Here, the geographical and temporal dynamics of the genetic diversity of Indian isolates from patients living in Ranchi, Raipur, Mewat, and Rourkela were analyzed. Typing and frequency of merozoite surface protein 1 and 2 genes (), their genotypes, clonality, heterozygosity, multiplicity of infection, and neutral evolution metrics were computed.