92 results match your criteria: "ICMR-National Institute of Immunohaematology[Affiliation]"
Br J Haematol
December 2024
ICMR-National Institute of Immunohaematology (NIIH), K.E.M. Hospital Campus, Mumbai, India.
Purpose: Wiskott-Aldrich syndrome (WAS) is an X-linked genetic disorder characterized by distinctive features including microthrombocytopenia, eczema and recurrent infections. In the present study we report clinical, immunological and molecular spectrum of 41 WAS patients diagnosed over last five years.
Methods: Clinical and family history was collected from case records.
Curr Genet
November 2024
ICMR - National Institute of Immunohaematology, Transfusion Medicine Department, 13th Floor New Multistoreyed Building, KEM Hospital Campus, Parel, Mumbai, Maharashtra, 400 012, India.
Plasmodium vivax malaria poses a major global health challenge, fueled by the parasite's ability to establish chronic infections via dormant liver hypnozoites that enable immune evasion and show transmission resilience. A key virulence determinant of P. vivax blood-stage infection is the ligand-receptor interaction of infected erythrocytes mediated by the Duffy Binding Protein (PvDBP) ligand.
View Article and Find Full Text PDFIndian J Hematol Blood Transfus
October 2024
Department of Transfusion Medicine, ICMR-National Institute of Immunohaematology (NIIH), 13th Floor, Room No 1324, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, Maharashtra 400012 India.
Oxf Med Case Reports
September 2024
Department of Dermatology, Seth G.S. Medical College and King Edward Memorial Hospital, Acharya Donde Marg, Parel, Mumbai 400012, India.
Br J Haematol
October 2024
ICMR-CRMCH, National Institute of Immunohaematology, Chandrapur Unit, Chandrapur, Maharashtra, India.
Sickle cell disease (SCD) is a complex genetic blood disorder characterized by abnormal haemoglobin, resulting in sickle-shaped red blood cells. While extensive research has concentrated on the genetic and physiological aspects of SCD, recent studies suggest a potential role of the human microbiome in SCD pathophysiology, adding new dimensions to its understanding. This review synthesizes current knowledge on the microbiome's involvement in SCD, focusing on alterations in the gut microbiome composition and diversity compared to healthy individuals, and their implications for disease pathogenesis.
View Article and Find Full Text PDFInt J Mol Sci
August 2024
Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
The liver is a complex organ that performs vital functions in the body. Despite its extraordinary regenerative capacity compared to other organs, exposure to chemical, infectious, metabolic and immunologic insults and toxins renders the liver vulnerable to inflammation, degeneration and fibrosis. Abnormal wound healing response mediated by aberrant signaling pathways causes chronic activation of hepatic stellate cells (HSCs) and excessive accumulation of extracellular matrix (ECM), leading to hepatic fibrosis and cirrhosis.
View Article and Find Full Text PDFJ Prim Care Community Health
August 2024
Indian Council of Medical Research, New Delhi, India.
Introduction: Venous thromboembolism (VTE) is a multifactorial condition and one of the leading causes of mortality and disability. The present study explores the factors associated with hospitalization duration among different types of venous thromboembolism diagnoses, such as deep vein thrombosis (DVT), pulmonary embolism (PE), and other forms of thrombosis.
Methods: The data included participants with VTE admitted to 13 hospitals within pan-India from June 2022 to December 2023 to the i-RegVed registry, where socio-demographic data, clinical history, and various factors associated with hospital length of stay (LOS) were included for analyses.
EClinicalMedicine
August 2024
Department of Haematogenetics, ICMR-National Institute of Immunohaematology, 13th Floor, New MS Building, KEM Hospital Campus, Parel, Mumbai 400 012, India.
J Clin Immunol
June 2024
Department of Pediatric immunology and leukocyte biology,, ICMR-National institute of immunohaematology (NIIH), Parel, Mumbai, 400012, Maharashtra, India.
Hematology
December 2024
Indian Council of Medical Research (ICMR), New Delhi, India.
Indian J Pediatr
June 2024
Department of Pediatric Immunology and Leucocyte Biology, ICMR-National Institute of Immunohaematology, Mumbai, India.
Pathogens
February 2024
Department of Pediatric Immunology, ICMR National Institute of Immunohaematology, Mumbai 400012, India.
The diagnosis and treatment of patients with mendelian susceptibility to mycobacterial disease (MSMD) pose consistent challenges due to the diverse infection spectrum observed in this population. Common clinical manifestations include Bacillus Calmette-Guérin vaccine (BCG) complications in countries where routine BCG vaccination is practiced, while in non-BCG-vaccinating countries, Non-Tuberculous Mycobacteria (NTM) is prevalent. In tuberculosis-endemic regions, Mycobacterium tuberculosis (MTB) has a high prevalence, along with other intracellular organisms.
View Article and Find Full Text PDFEpidemiol Infect
March 2024
ICMR School of Public Health, ICMR-National Institute of Epidemiology, Chennai, India.
In the third week of September 2022, an outbreak of measles was reported from a slum in Eastern Mumbai, India. We sought to investigate whether failure to vaccinate or vaccine failure was the cause. We constructed an epidemic curve, drew a spot map, and calculated the attack rate and case-fatality ratio.
View Article and Find Full Text PDFParasit Vectors
March 2024
Field Unit, ICMR-National Institute of Malaria Research, Chennai, India.
Background: The global temperature has significantly risen in the past century. Studies have indicated that higher temperature intensifies malaria transmission in tropical and temperate countries. Temperature fluctuations will have a potential impact on parasite development in the vector Anopheles mosquito.
View Article and Find Full Text PDFOncology
October 2024
Department of Cytogenetics, ICMR-National Institute of Immunohaematology, Mumbai, India.
Introduction: Myelodysplastic syndrome (MDS) is a heterogeneous disease characterized by cytopenia, marrow dysplasia and has a propensity to develop into acute myeloid leukemia. The disease progression is majorly affected by genetic defects. However, about 40-50% of patients with MDS present with a normal karyotype and develop different courses of disease.
View Article and Find Full Text PDFHeliyon
February 2024
Transfusion Transmission Disease Department, ICMR- National Institute of Immunohaematology, Mumbai, Maharashtra, 400 012, India.
Background: Hepatitis B Virus (HBV), and occult Hepatitis B in particular, is a major concern in the transfusion scenario, especially in endemic countries. This study attempted to estimate the prevalence of occult Hepatitis B infection (OBI) among voluntary blood donors in Maharashtra and to evaluate the role of combined screening strategy with implications in minimizing the current transfusion risks of seropositive OBI.
Methods: Donor samples were collected from 80 eligible blood banks from various districts of Maharashtra between 2014 and 2017.
Syst Rev
February 2024
Department of Paediatric Immunology & Leukocyte Biology, ICMR-National Institute of Immunohaematology, 13th Floor, New MS Building, KEM Hospital Campus, Parel, Mumbai, 400 012, India.
Background: Hydroxyurea is an affordable drug that reduces vaso-occlusive crises and transfusion requirements in sickle cell disease. However, its effectiveness in preventing chronic organ damage is still unclear. This systematic review and meta-analysis aimed to evaluate the role of hydroxyurea in preventing organ morbidity.
View Article and Find Full Text PDFCell Death Discov
October 2023
Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA.
The conventional understanding that chimeric RNAs are unique to carcinoma and are the products of chromosomal rearrangement is being challenged. However, experimental evidence supporting the function of chimeric RNAs in normal physiology is scarce. We decided to focus on one particular chimeric RNA, CTNNBIP1-CLSTN1.
View Article and Find Full Text PDFFront Digit Health
September 2023
Division of Epidemiological and Communicable Diseases, ICMR Hqrs., Ramalingaswami Bhavan, Delhi, India.
J Allergy Clin Immunol Glob
August 2023
Department of Blood and Marrow Transplantation, Bai Jerbai Wadia Hospital for Children, Mumbai, India.
Br J Haematol
February 2024
ICMR-National Institute of Immunohaematology, Mumbai, India.
Synonymous mutations were considered to lack functional roles in human diseases; however, distinguishing deleterious synonymous mutations from benign ones is still a challenge. In this article, we identified a deleterious synonymous mutation β-codon 16 (C>T). HBB: c.
View Article and Find Full Text PDFJ Clin Immunol
November 2023
Indian Council of Medical Research (ICMR) - National Institute of Immunohaematology (NIIH), KEM Hospital, 13th floor New Multistorey Building, Parel Mumbai, Mumbai, India.
Living organisms are exposed to exogenous and endogenous agents that affect genomic integrity by creating DNA double strand breaks (DSBs). These breaks are repaired by DNA repair proteins to maintain homeostasis. Defects in DNA repair pathways also affect lymphocyte development and maturation, as DSB sites are critical intermediates for rearrangements required for V(D)J recombination.
View Article and Find Full Text PDFThe emergence of vaccine-derived polioviruses (VDPVs) in patients with Primary Immunodeficiency (PID) is a threat to the polio-eradication program. In a first of its kind pilot study for successful screening and identification of VDPV excretion among patients with PID in India, enteroviruses were assessed in stool specimens of 154 PID patients across India in a period of two years. A total of 21.
View Article and Find Full Text PDFItal J Pediatr
July 2023
Department of Haematogenetics, ICMR- National Institute of Immunohaematology, 13th Floor, New Multi Storeyed Building, KEM Hospital Campus, Parel, Mumbai, 400012, India.
Background: Congenital dyserythropoietic anemias (CDAs) are a very rare and heterogeneous group of disorders characterized by ineffective erythropoiesis. CDA II is caused by mutations in the SEC23B gene. The most common mutation reported in India is c.
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