6 results match your criteria: "ICAR-National Institute of High Security Animal Diseases (NIHSAD)[Affiliation]"

The cross-species transmissibility of SARS-CoV-2 infection has necessitated development of specific reagents for detecting infection in various animal species. The spike glycoprotein of SARS-CoV-2, which is involved in viral entry, is a highly immunogenic protein. To develop assays targeting this protein, we generated eight monoclonal antibodies (mAbs) against the S1 and seven against the S1/S2 protein (ectodomain) of SARS CoV-2.

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The global spread of H5N1 highly pathogenic avian influenza virus (HPAIV) in poultry has caused great economic loss to the poultry farmers and industry with significant pandemic threat. The current study involved production of recombinant HA1 protein of clade 2.3.

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The Indian poultry industry is one of the fast-growing sectors of which duck farming plays an important role. Duck population in India is 33.51 million that is concentrated towards north-east and southern parts of the country who rears mainly for eggs and meat.

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Particulate matter (PM) enhances RNA virus infection through modulation of innate immune responses.

Environ Pollut

November 2020

Laboratory of Immunology and Infectious Disease Biology, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, 462066, MP, India; WPI Immunology, Frontier Research Centre, Osaka University, Osaka, 5650871, Japan. Electronic address:

Sensing of pathogens by specialized receptors is the hallmark of the innate immunity. Innate immune response also mounts a defense response against various allergens and pollutants including particulate matter present in the atmosphere. Air pollution has been included as the top threat to global health declared by WHO which aims to cover more than three billion people against health emergencies from 2019 to 2023.

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In a cross-sectional study, prevalence of ovine herpesvirus 2 (family: Herpesviridae, subfamily: Gammaherpesvirinae, genus Macavirus and species: Ovine herpesvirus 2) infection was estimated in sheep population of Karnataka state in India. Based on the three stage cluster sampling method, whole blood samples (356) of sheep were collected from 11 sheep-dense districts of the state. The samples were tested for presence of OvHV-2 genome by recommended hemi-nested polymerase chain reaction (PCR) test.

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Article Synopsis
  • - The study investigates highly pathogenic avian influenza (HPAI) H5N1 viruses in Indian poultry, particularly focusing on the clade 2.3.2.1, which has been prevalent since 2011 and differs antigenically from other clades like 2.2.
  • - Researchers characterized 11 selected H5N1 viruses using antigenic cartography and phylogenetic analysis to identify differences between and within the clades, emphasizing the variability and potential implications for vaccine development.
  • - The analysis included the glycosylation patterns of Hemagglutinin (HA) and growth kinetics in cell cultures, discovering that some viruses exhibit better replication, which may inform future strategies in creating effective H5 vaccine
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