29 results match your criteria: "IBSAL University Hospital of Salamanca[Affiliation]"
Significant advances have been achieved in recent years in the identification of the genetic and the molecular alterations of pancreatic ductal adenocarcinoma (PDAC). Despite this, at present the understanding of the precise mechanisms involved in the development and malignant transformation of PDAC remain relatively limited. Here, we evaluated for the first time, the molecular heterogeneity of PDAC tumors, through simultaneous assessment of the gene expression profile (GEP) for both coding and non-coding genes of tumor samples from 27 consecutive PDAC patients.
View Article and Find Full Text PDFAtypical progressive multifocal leukoencephalopathy in a patient with antisynthetase syndrome.
Intern Med
August 2015
Department of Internal Medicine, Unit of Infectious Diseases. IBSAL. University Hospital of Salamanca. CIETUS, University of Salamanca, Spain.
Article Synopsis
- Antisynthetase syndrome is a serious disorder related to dermatomyositis/polymyositis, associated with significant health risks.
- A 71-year-old man diagnosed with this syndrome was treated with rituximab, but nearly three years later, he experienced severe neurological decline, including hemiparesis and cognitive deterioration.
- The patient's condition was ultimately linked to progressive multifocal leukoencephalopathy, and the rituximab treatment contributed to the risk of these complications.
The role of the TERC-63G>A and TERT-1327C>T telomerase polymorphisms in the study of men with acute coronary syndrome.
Minerva Cardioangiol
December 2015
Department of Cardiology, IBSAL-University Hospital of Salamanca, Salamanca, Spain -
Aim: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some ageing related diseases, like cardiovascular disease. Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear.
View Article and Find Full Text PDFPrognostic value of telomere length in acute coronary syndrome.
Mech Ageing Dev
May 2013
IBSAL-University Hospital of Salamanca, Department of Cardiology, Salamanca, Spain.
Telomere and telomerase are involved in cellular and organismal ageing and have been related to human diseases. Coronary artery disease is one of the most common age-related health problems in developed countries. Nevertheless, the specific role of cellular ageing in this process is still unclear.
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