496 results match your criteria: "IBN Rochd University Hospital[Affiliation]"
Unstable Spinal Fracture With Arteria Lusoria: Management to Mitigate Aortic Risks.
Cureus
September 2024
Anesthesiology and Critical Care, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MAR.
Article Synopsis
- Aortic injuries related to unstable spinal fractures, although rare, can be life-threatening and require quick, collaborative medical responses to avoid serious complications.
- A case study of a woman with a spinal fracture after a road accident highlighted the potential dangers of surgery without an aortic prosthesis, which could lead to severe bleeding, while using a prosthesis carries risks of mini-strokes and other complications.
- The treatment approach involved using a thoracic prosthesis prior to spinal surgery, emphasizing the need for careful planning and consideration of the patient's unique anatomy to minimize risks of aortic injury during the surgical process.
Case Report of Two Independent Moroccan Families with Syndromic Epidermodysplasia Verruciformis and STK4 Deficiency.
Viruses
September 2024
Laboratory of Clinical Immunology-Inflammation and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 20250, Morocco.
Article Synopsis
- Epidermodysplasia verruciformis (EV) is a rare skin condition linked to β-human papillomaviruses (HPV) in immunodeficient individuals, presenting as flat warts and pityriasis-like lesions.
- The study details three patients from two families with syndromic EV, identified through whole exome sequencing to have new homozygous variants in the STK4 gene, resulting in a premature stop codon.
- STK4 deficiency causes a combined immunodeficiency leading to increased susceptibility to various infections and autoimmune issues, as evidenced by immunophenotyping showing significant CD4 T cell deficiency in the patients.
Open Anterior Subscapularis Release for Adduction and Medial Rotation Shoulder Contracture in Neonatal Brachial Plexus Palsy.
Afr J Paediatr Surg
September 2024
Department of Paediatric Orthopaedics and Traumatology, Abderrahim Harouchi Mother and Child Hospital, Ibn Rochd University Hospital, Casablanca, Morocco.
Article Synopsis
- The study examines the effectiveness of open anterior subscapularis release surgery in children over 12 months with unresolved neonatal brachial plexus palsy, focusing on improving shoulder contracture.
- Results showed a significant improvement in shoulder function scores and movements such as abduction and lateral rotation, with notable enhancements in activities like bringing hands to the mouth and head.
- The findings indicate that children with more severe injuries experience greater functional recovery after surgery, although there was no significant change in medial rotation of the shoulder.
Motorcycle Wheel Spoke Injury to the Ankle and Foot in Children: A Cross-sectional Observational Study.
Afr J Paediatr Surg
September 2024
Department of Paediatric Orthopaedics and Traumatology, Abderrahim Harouchi Mother and Child Hospital, Ibn Rochd University Hospital, Casablanca, Morocco.
Article Synopsis
- Motorcycle accidents involving wheel spokes have become a significant cause of ankle and foot injuries in children under 16 years old in developing countries, particularly during afternoon rides as pillion passengers.
- The study analyzed 30 cases over 11 years, revealing a notable increase in injuries after 2015, with a majority suffering severe injuries such as tendon ruptures and bone fractures.
- Key findings indicate that larger wound sizes and loss of soft tissue are linked to the severity of injuries, highlighting the need for better prevention strategies for child passengers.
Extranodal intraductal papilloma in axillary supernumerary breast.
Radiol Case Rep
November 2024
Department of Radiology, Radiology Service of Mother-Child Hospital Abderrahim Harouchi, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy of Casablanca, Morocco.
Extranodal intraductal papilloma of the unilateral axillary supernumerary breast is a rare and unusual medical condition. This condition involves the development of a benign tumor, known as a papilloma, in the ducts of supernumerary breast tissue found in the axilla. We report a rare case of extranodal papilloma of an extranodal intraductal papilloma of a unilateral axillary supernumerary breast in a 70-year-old woman, who presented with a right axillary mass.
View Article and Find Full Text PDFPrevalence of Healthcare-Associated Infections in a Tertiary Hospital in Casablanca, Morocco, 2021.
Cureus
August 2024
Laboratory of Epidemiology, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, MAR.
Article Synopsis
- During the COVID-19 pandemic, healthcare workers faced increased workloads that potentially impacted infection control measures and raised rates of healthcare-associated infections (HAIs) at Ibn Rochd University Hospital Center (IRUHC).
- A survey conducted on hospitalized patients revealed a 9.7% prevalence of HAIs, with the highest rates (44.2%) found in intensive care units (ICUs), predominantly due to nosocomial pneumonia.
- The study identified significant factors associated with HAIs, including the use of invasive medical devices, higher physical health scores, and longer hospital stays, highlighting the urgent need for improved monitoring and hygiene practices due to the presence of drug-resistant infections.
Insights into the genetic theory of infectious diseases.
Tunis Med
September 2024
Laboratory of Clinical Immunology, Inflammation and Allergies LICIA, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Article Synopsis
- Classical microbiology and immunology have made significant strides in controlling infectious diseases, but recent pandemics like SARS-COV-2 expose limitations in these traditional methods.
- Human genetics plays a crucial role in determining an individual's susceptibility or resistance to infections, influencing how different people react to the same pathogens.
- Integrating genetic insights with microbiology can enhance our understanding of infections and help develop better prevention and treatment strategies.
A novel variant of gene is potentially associated with alpha-thalassemia X-linked intellectual disability syndrome: Case report and literature review.
SAGE Open Med Case Rep
September 2024
Medical Genetics Laboratory, Ibn Rochd University Hospital, Casablanca, Morocco.
Article Synopsis
- - The gene associated with alpha-thalassemia mental retardation X-linked is a chromatin remodeler linked to severe conditions like intellectual disability and facial anomalies, among others.
- - A report highlights a 7-year-old Moroccan boy with significant intellectual challenges, autistic traits, specific facial features, and other physical issues, linked to a newly discovered variant in this gene.
- - The identified variant (c.745G>A) shows strong predictions of being harmful and impacts a highly conserved protein domain, indicating further research is necessary to confirm its significance for proper genetic counseling.
Study of Knowledge, Attitudes, Acceptability and Preference of Home-based HPV Self-Sampling Among a Population of Moroccan Women.
J Cancer Educ
December 2024
Laboratory of Health Sciences and Technologies, Epidemiology and Biomedical Unit, Higher Institute of Health Sciences, Hassan First University of Settat, Settat, Morocco.
Article Synopsis
- In Morocco, cervical cancer screening rates are low, highlighting the necessity for new screening strategies, such as vaginal self-sampling for HPV testing.
- A pilot study surveyed 400 Moroccan women aged 25 to 65, finding that 95% were willing to undergo vaginal self-sampling, with 73.6% preferring to do it at home.
- Factors influencing preferences included beliefs about screening necessity, age, marital status, and perceived severity of cervical cancer, suggesting self-sampling could enhance screening accessibility in Morocco.*
Libman-Sacks Endocarditis in a Congenital Valve Defect: A Case Report.
Cureus
August 2024
Rheumatology, University Hospital of Ibn Rochd, Casablanca, MAR.
Article Synopsis
- Libman-Sacks endocarditis (LSE) is a rare complication of systemic lupus erythematosus (SLE), marked by noninfectious growths on healthy heart valves.
- A 20-year-old woman with SLE and a heart valve anomaly experienced serious symptoms like severe shortness of breath and chest pain despite a year of treatment.
- Though initially treated with corticosteroids and other medications, her condition worsened and ultimately led to a non-rescueable state, highlighting the risks associated with LSE in patients with pre-existing heart issues.
Management of a Pott puffy tumor: Case report and literature review.
Int J Surg Case Rep
October 2024
Department of Otolaryngology, Head and Neck Surgery, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Article Synopsis
- Pott's puffy tumor (PPT) is a rare condition primarily affecting children and teens, characterized by frontal bone osteomyelitis and a subperiosteal abscess, necessitating urgent treatment to avoid serious complications.
- A case study of a 29-year-old woman revealed a post-traumatic periorbital swelling due to this condition, which was confirmed via CT scan and treated with surgery and antibiotics.
- Effective management includes prompt diagnosis through imaging, immediate intravenous antibiotics, and potential surgical interventions to prevent life-threatening complications associated with PPT.
Cerebral Thrombophlebitis Complicating Coeliac Disease.
Cureus
August 2024
Pediatric Gastroenterology, Abderrahim El Harouchi Hospital, Ibn Rochd University Hospital, Casablanca, MAR.
Article Synopsis
- Thromboembolic complications, particularly abdominal venous thrombosis, are uncommon in coeliac disease, while cerebral thrombosis is very rare.
- Investigating thrombotic risk factors in patients with coeliac disease is crucial for understanding potential complications.
- A clinical case is presented involving a child with coeliac disease who developed cerebral thrombophlebitis linked to antithrombin III deficiency and anticardiolipin antibodies.
Immunotherapy and PD-L1 Tumor Expression in Moroccan Non-Small Cell Lung Cancer Patients with Various Metastasis.
Asian Pac J Cancer Prev
August 2024
Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco.
Article Synopsis
- The study investigates how tumor PD-L1 expression and distant metastasis affect the effectiveness of immunotherapy in Moroccan patients with non-small cell lung cancer (NSCLC).
- It analyzed data from 40 patients treated between January 2019 and February 2023, using immunohistochemistry and qPCR to determine cancer markers and expression levels.
- Results indicated that positive PD-L1 expression correlates with shorter survival rates, while a high metastatic burden significantly lowers treatment response and survival outcomes.
Sulfuric acid-induced skin neoplasms in immunocompetent mice.
Exp Dermatol
August 2024
Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca, Morocco.
Article Synopsis
- - This study examines the effects of long-term exposure to sulfuric acid (SA) on skin health in mice, focusing on its potential to cause cancer over a 16-week period.
- - Results showed that chronic exposure resulted in skin changes like inflammation, increased skin thickness, and early signs of cancer, demonstrated by elevated markers such as p53 and Ki-67.
- - The research highlights that SA exposure leads to oxidative stress in the skin, emphasizing the need for better safety measures for people working with or around sulfuric acid.
[Not Available].
Tunis Med
August 2024
Clinical Immunology, Inflammation and Allergy Laboratory, Faculty of Medicine and Pharmacy, Casablanca, Hassan II University of Casablanca.
Tuberculous meningitis, a severe form of tuberculosis caused by Mycobacterium tuberculosis (BK), remains a major public health challenge worldwide. In addition to the complex mechanisms of the innate and adaptive immune response against Mycobacterium tuberculosis, there is a crucial genetic dimension to consider. Individuals with specific genetic variations may have altered immune responses that make them more susceptible to this form of tuberculosis.
View Article and Find Full Text PDFSuccessful Management of Post-Laser Hyperpigmented Scar with Intralesional Tranexamic Acid Injections.
Dermatol Pract Concept
July 2024
Dermatology and Venerology Department, Ibn Rochd University Hospital, Hassan II University, Casablanca, Morocco.
A Cross-Sectional Study of Congenital Adrenal Hyperplasia.
Cureus
June 2024
Pediatrics Department, Abderrahim Harouchi Mother-Child Hospital, Ibn Rochd University Hospital, Casablanca, MAR.
Article Synopsis
- * A study at Abderrahim Harrouchi Children's Hospital analyzed 184 CAH cases over 11 years, finding that most diagnoses occurred early (median age 1.5 months) and that a high percentage of families reported consanguinity and previous fatalities related to the condition.
- * The most common form of CAH was the classic type (72%), with the majority showing 21-hydroxylase deficiency, and 40.7% of affected children required
Human Genetic and Immunological Determinants of SARS-CoV-2 Infection and Multisystem Inflammatory Syndrome in Children.
Clin Exp Immunol
July 2024
Laboratory of Clinical Immunology, Inflammation and Allergies (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 20250, Morocco.
Article Synopsis
- SARS-CoV-2 causes pneumonia and severe respiratory issues, especially in patients with genetic defects in type I interferon, impacting individuals differently based on age and gender.
- About 3-5% of critical COVID-19 patients under 60 years have genetic defects in interferon production, while around 15-20% of those over 70 show autoantibodies against type I interferons.
- This review discusses the links between genetic and immunological factors contributing to severe COVID-19 and pediatric multisystem inflammatory syndrome (MIS-C), emphasizing the need for more research to develop targeted treatments and strategies for future viral infections.
Lead in umbilical cord blood and associated factors in Casablanca Morocco: A preliminary results.
J Trace Elem Med Biol
September 2024
Department of Zoology and Animal Ecology, Scientific Institute, Mohammed V University in Rabat, B.P. 1040, Ibn Battuta Av, Rabat 10100, Morocco.
Background: Lead is the most common toxic metal to which Moroccans are exposed. Given the susceptibility of the fetus to lead, it is crucial to assess prenatal lead exposure. However, in Morocco, no study has assessed prenatal exposure to lead.
View Article and Find Full Text PDFImpact of COVID-19 on child tuberculosis hospitalization.
Tunis Med
July 2024
Laboratory of Clinical Immunology, Inflammation and Allergy (LICIA), Casablanca Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Article Synopsis
- Morocco has seen progress in tackling tuberculosis, but the Covid-19 pandemic disrupted tuberculosis control worldwide and altered its epidemiology.
- A retrospective study of children hospitalized for tuberculosis at a Casablanca hospital from 2018 to 2022 revealed significant fluctuations in case numbers before, during, and after the pandemic.
- The data showed a drop in annual cases during quarantine (23) compared to pre-pandemic (49) and a rise post-quarantine (81), with more extrapulmonary cases observed during the pandemic.
Glioblastoma Vaccines as Promising Immune-Therapeutics: Challenges and Current Status.
Vaccines (Basel)
June 2024
Laboratory of Biomedical and Translational Research, Faculty of Medicine, Pharmacy and Dental Medicine of Fez, Sidi Mohamed Ben Abdellah University, Fez 30070, Morocco.
Article Synopsis
- Glioblastoma (GBM) is a very common and aggressive brain tumor, with standard treatments like surgery and chemotherapy not significantly improving patient outcomes.
- *Current research is focusing on immunotherapy methods such as vaccines and T-cell therapies, which are showing encouraging results in trials.
- *The review discusses the challenges of immunotherapy, identifies key biomarkers as potential therapeutic targets, and suggests strategies to enhance the effectiveness of treatments for GBM.
Global epidemiology of heart failure.
Nat Rev Cardiol
October 2024
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Article Synopsis
- Heart failure (HF) is a complex condition causing significant health issues, with its natural history well understood but evolving epidemiological data driven by demographic changes and treatment advancements.
- Although incidences of HF are stabilizing or declining in high-income countries, its prevalence is on the rise, particularly among older adults and increasingly younger populations, especially with the shift towards HF with preserved ejection fraction.
- There are disparities in understanding HF in low and middle-income countries due to lacking data, highlighting the need for targeted surveillance and resource allocation to address these geographic differences.
[Not Available].
Tunis Med
June 2024
Laboratory of Chemistry-Biochemistry, Environment, Nutrition and Health, Faculty of Medicine and Pharmacy, University of Hassan Casablanca, Morocco.
Article Synopsis
- The rising number of hip arthroplasties in Morocco is leading to an increase in periprosthetic fractures, creating challenges for orthopedic surgeons due to the lack of a standardized treatment protocol.
- The study analyzed the management of these fractures by examining 19 patients treated in a trauma-orthopedics department over seven years, with a majority being older women and specific fracture classifications highlighted.
- Results showed successful outcomes for all patients with individualized treatment plans, emphasizing the need for tailored approaches in managing these complex cases.
Drug-resistant epilepsy in Morocco: description, prevalence and predictive factors in Casablanca-Settat region.
J Clin Neurosci
August 2024
Laboratory of Research on Neurologic, Neurosensorial Diseases and Disability, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco; Department of Neurosurgery, IBN ROCHD University Hospital, Casablanca, Morocco.
Article Synopsis
- Drug-resistant epilepsy (DRE) affects about one-third of people with epilepsy, and a study conducted in Morocco found a DRE prevalence of 29.4% among 446 participants with an average age of 25.
- The study identified key predictive factors for DRE, including single marital status, comorbidities, structural causes, pre-ictal auras, EEG abnormalities, and use of allopathic treatments.
- To address the high prevalence of DRE, the study suggests increasing awareness among people with epilepsy, improving healthcare access, and advancing epilepsy surgery options, particularly for children.
Antiseizure medication adherence and epilepsy surgery attitude in people with epilepsy in Morocco: A cross-sectional study.
Epilepsy Behav Rep
May 2024
Laboratory of Research on Neurologic, Neurosensorial Diseases and Disability, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Article Synopsis
- The study assessed the rates and factors influencing non-adherence to antiseizure medications (non-AMA) and attitudes towards epilepsy surgery (ES) among Moroccan individuals with epilepsy.
- Among 294 participants, 24.5% showed non-AMA primarily due to indifference, while 33.3% refused surgery, mainly due to fear.
- Factors like being male and having a family history of epilepsy were linked to non-AMA, whereas certain treatment types and seizure classifications predicted refusal of surgery.