Multisystem inflammatory syndrome in children (MIS-C) temporally associated with SARS-CoV-2: the first clinical case in Ternopil, Ukraine.

Introduction: Coronavirus disease (COVID-19) has led to a global pandemic among patients of all ages around the world. A new delayed inflammatory syndrome, with potentially severe evolution, has been described in the pediatric population, a population previously considered to be less vulnerable to the severe forms of COVID-19.

Case Report: We describe the first clinical case of multisystem inflammatory syndrome (MIS-C) in a 7-year-old child of the Ternopil region, Ukraine.

Thermographic differential diagnosis of acute tonsillitis and exacerbation of chronic tonsillitis.

Objective: The aim: To elaborate the thermosemiotics of acute and chronic tonsillitis during exacerbation.

Patients And Methods: Materials and methods: 48 patients with acute tonsillitis and 19 patients with chronic tonsillitis were examined during disease exacerbation. Thermographic examination was carried out by the medical thermometer TI-120.

Effects of quercetin on antioxidant potential in the experimental periodontitis development.

The results of experimental research of antioxidant system are presented in this article. Superoxide dismutase activity, catalase, and ceruloplasmin have been determined on the 7 and 14 days of experimental periodontitis development both without correction and with the injection of a water-soluble quercetin drug (corvitin). Hence, there was a decrease in superoxide dismutase activity, intensive increase in catalase activity, and ceruloplasmin maintenance in the blood serum during acute period of inflammatory process.

[The evaluation of hunters and foresters' knowledge of the possible ways of preventing infections].

Background: This study is aimed at evaluating the awareness among hunters and foresters concerning the activities undertaken for the prevention of infections.

Material And Methods: The study group included 236 hunters from Poland and 339 foresters from Ukraine. The study was based on an original questionnaire including questions which concerned the applied methods of removing ticks attached to the skin, the kind of preventive measures undertaken to avoid tick bites, the evaluation of knowledge concerning the prevention of tick-borne diseases, as well as the participants' willingness to be educated on this issue.

Adsorptive therapy as a modificator for tumor-host interaction.

The potential of one of the adsorption methods, enterosorption (ES), using the new generation of carbon adsorbents to correct the negative manifestations of tumor-host interaction in the framework of paraneoplastic syndrome (PNS) as well as systemic toxicity of chemo- and radiation therapy, is discussed. The ES influence on the development of PNS was demonstrated in C57/BL6 mice with transplanted Lewis lung carcinoma. Two-week administration of carbon enterosorbents resulted in a significant suppression of metastasis and correction of tumor-related anemia, activation of granulocytic line in the bone marrow with nearly 3-fold enhancement of its mitotic activity.

[CHANGES IN THE INDICATORS OF LIPID PEROXIDAL OXIDATION AND ANTIOXIDANT SYSTEM IN THE SERUM OF THE BLOOD IN ANIMALS WITH EXPERIMENTAL PERIODONTITIS WITH CHANGED REACTIVITY].

The purpose of the experimental study was to study the activity of lipid peroxidation and antioxidant systems in animals of different ages with experimental periodontitis with altered reactivity. Experiments were carried out on 30 non-linear white rats aged 2 months, which were divided into three groups: Group I - 10 animals with a hypoergic reaction, which was modeled by the administration of cyclophosphamide; Group II - 10 animals with hyper-hypergly reaction, which was modeled by administration of pyrogenal; Group III - 10 animals with normal reaction - a control group, which was intramuscularly injected with 1 ml of saline. Blood sampling and killing of animals were performed under thiopental anesthesia 7 days after the start of the experiment.

A calcium channel blocker nifedipine distorts the effects of nano-zinc oxide on metal metabolism in the marsh frog .

Global decline of amphibian populations causes particular concern about their vulnerability to novel environmental pollutants, including engineering nanomaterials and pharmaceutical products. We evaluated the bioavailability of nanoform of zinc oxide (n-ZnO) in frog and determined whether co-exposure to a common pharmaceutical, a calcium-channel blocker nifedipine (Nfd) can affect this bioavailability. Male frogs were exposed for 14 days to the tap water (Control) and n-ZnO (3.

Medical and social issues of cardiovascular diseases and their solution based on the experimental study of myocardial fibrosis.

Objective: Introduction: The prevalence and incidence of cardiovascular diseases have been attracting considerable attention in recent decades. This is partly due to the fact that myocardial fibrosis is the major consequence of the most nosological units of cardiovascular diseases. We believe that early pathogenic therapy of myocardial fibrosis should be taken into consideration as a solution to this issue.

[THE STRUCTURE OF THE ILEUM AFTER THE RESECTION OF LIVER PARENCHYMA].

The ileum was morphologically examined in 45 sexually mature white male rats, which were divided into 3 groups: I group included 15 intact animals, II - 15 rats, in which 31.5% of the liver parenchyma was removed, III - 15 animals after resection 58,1% of liver parenchyma. Euthanasia of rats was performed by bloodletting under the conditions of thiopental anesthesia 1 month after the beginning of the experiment.

Long-Term Depuration of Crassostrea virginica Oysters at Different Salinities and Temperatures Changes Vibrio vulnificus Counts and Microbiological Profile.

Previous short-duration depuration studies with the eastern oyster ( Crassostrea virginica) demonstrated difficulty in achieving significant naturally incurred Vibrio vulnificus population count reductions. The present study used long-duration depuration (14 days) at controlled temperatures (10 or 22°C) and salinities (12, 16, or 20 mg/g). All depuration temperature-salinity combinations significantly reduced V.

THERMOSEMIOTICS OF ACUTE TONSILLITIS.

Research purpose - to set the thermosemiotics of acute tonsillitis by the exposure of infrared features in a submandibular region and on the hands of healthy people, and also comparisons of the got results with the corresponding indexes of such patients. 95 patients with acute tonsillitis, and also 32 healthy volunteers with a normal temperature bodies without tonsil pathology were examined. Age of inspected persons was from 20 to 58 years.

Regular and prolonged skin-to-skin contact improves short-term outcomes for very preterm infants: A dose-dependent intervention.

Introduction: Skin-to-skin contact (SSC) is a cornerstone of neurodevelopment and family-oriented care for preterm infants. The purpose of the present study was to investigate the effectiveness of skin-to-skin contact in preterm babies depending on regularity, duration, and the period of the first contact.

Materials And Methods: This retrospective study involved 26 premature infants with gestational age 24/0-28/6 weeks who were treated in the neonatal intensive care unit and neonatal department.

Bioenergetic responses of freshwater mussels Unio tumidus to the combined effects of nano-ZnO and temperature regime.

Bivalves from the cooling reservoirs of electrical power plants (PP) are exposed to the chronic heating and chemical pollution making them a suitable model to study the combined effects of these stressors. We investigated the effect of in situ exposures to chemical and thermal pollution in the PP cooling ponds on the metabolic responses of unionid bivalves (Unio tumidus) to a novel widespread pollutant, ZnO nanoparticles (nZnO). Male U.

FORMATION OF BIOFILMS BY BACTERIA EXCRETED FROM CHRONIC ANAL FISSURE AND THE INFLUENCE OF THE DIRECT CURRENT ELECTRIC FIELD ON THEM.

Chronic anal fissures (CAF) are considered to be the illness with chronic course and characterized by frequent relapses. Although today the attention of researchers concerning the role of biofilm bacterial forms in pathogenesis of this pathology remains inadequate. Тherefore we investigated biofilms density of bacteria isolated from CAF and determined the current density possessing an optimal bactericidal effect on bacteria and destruct microbial biofilms.

Pre-Clinical and Clinical Efficiency of Complexes of Oligoribonucleotides with D-Mannitol against Respiratory Viruses.

Oligoribonucleotides-D-mannitol (ORNs-D-M) complexes possess antiviral, anti-inflammatory, and immunomodulatory actions. The aim of the present study was to evaluated an antiviral effect of ORNs-D-M against parainfluenza virus type 3 (PIV3); influenza CA709, PR834; avian influenza virus H5N2 (AIV) in vitro by a TCID; hemadsorption and neuraminidase activity assays; and clinical efficiency of ORNs-D-M in patients with acute respiratory infections (ARIs) of various etiologies by PCR assay and AmpliSens test systems. It was observed that ORNs-D-M have an antiviral activity against the influenza CA709, PR834, PIV3, and AIV in vitro.

The effect of the proteolisis' system activity for the trophological status of patients with osteoarthrosis and excretory insufficiency of pancreas.

Objective: Introduction:The excretory insufficiency of pancreas in patients with primary osteoarthrosis is formed at the comorbid pathologies and as a result of long-term treatment of osteoarthrosis using the non-steroidal anti-inflammatory drugs, steroids, chondroprotectors and chondrostimulators etc. The aim: to study the state of the proteolysis system and immune status, the presence and depth of the dysbiosis of colon in patients with primary osteoarthrosis against a violation of their excretory insufficiency of pancreas.

Patients And Methods: Materials and methods: There were 64 outpatients with primary OA (group 1) and 74 patients with primary OA in combination with diseases associated with EIP (group 2).

Clinico-pathogenic aspects of osteodeficiency in osteoarthritis in combination with chronic pancreatitis.

Objective: Introduction: Pathology of the musculoskeletal system creates a number of important and complex medical problems affecting the economic situation of society, health and quality of life of individuals and their families. One of these problems and the most common disease of the joints which is diagnosed in 20% of the population of the planet is osteoarthritis (OA). The aim: The article deals with modern views on the problem of comorbidity of osteoarthritis, chronic pancreatitis and osteodefiсiency.

combination effect of hypertonic disease with chronic pancreatitis on the processes maintain homeostasis.

Objective: Introduction: Abnormalities comorbidity - a frequent phenomenon in medical practice. This determines the relevance of research processes maintaining homeostasis with a combination of various diseases. The aim of this study was to examine and compare the character of vegetative, antioxidant, kallikrein-kinin system and parameters of endogenous intoxication disorders in the patients with isolated essential hypertension and with combination of hypertonic disease and chronic pancreatitis.

[ULTRASTRUCTURAL CHARACTERISTICS OF RATS TESTICLES UNDER SPERMATIC CORD STENOSIS AND AFTER BLOOD FLOW RESTORATION BY DIFFERENT METHODS].

Hemodynamic disorders in the testicles cause chronic organ hypoxia with damage of its stroma and seminiferous tubules, which plays a leading role in the pathogenesis of the testicular form of male infertility development. The aim of the work was to establish the features of ultrastructural reorganization of the testicles tissue and its vascular bed under circulatory hypoxia conditions and after restoration of blood flow in the organ. The study was conducted on 84 white adult male rats.

Vulnerability of marsh frog Pelophylax ridibundus to the typical wastewater effluents ibuprofen, triclosan and estrone, detected by multi-biomarker approach.

Pharmaceutical and personal care products (PPCPs) are the environmental pollutants of growing concern. The aim of this study was to indicate the effects of typical PPCPs on the marsh frog Pelophylax ridibundus. We treated male frogs with waterborne ibuprofen (IBU, 250ng·L), triclosan (TCS, 500ng·L), or estrone (E1, 100ng·L) for 14days.

Biomineralization-related specialization of hemocytes and mantle tissues of the Pacific oyster .

The molluscan exoskeleton (shell) plays multiple important roles including structural support, protection from predators and stressors, and physiological homeostasis. Shell formation is a tightly regulated biological process that allows molluscs to build their shells even in environments unfavorable for mineral precipitation. Outer mantle edge epithelial cells (OME) and hemocytes were implicated in this process; however, the exact functions of these cell types in biomineralization are not clear.

Human Papilloma Virus-Associated Lips Verrucous Carcinoma in HIV-Infected Male.

Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips.

Endocrine and cellular stress effects of zinc oxide nanoparticles and nifedipine in marsh frogs Pelophylax ridibundus.

Freshwater organisms including amphibians experience increasing exposures to emerging pollutants such as nanoparticles and pharmaceuticals, which can affect their fitness and performance. We studied the effects of two common pollutants extensively used in industry, pharmaceutical and personal care products, nano-zinc oxide (nZnO) and a Ca-channel blocker nifedipine (Nfd), on endocrine status and cellular stress markers of the marsh frog Pelophylax ridibundus. Males were exposed for 14days to nZnO (3.

Long-Term Acclimation to Different Thermal Regimes Affects Molecular Responses to Heat Stress in a Freshwater Clam Corbicula Fluminea.

Global climate change (GCC) can negatively affect freshwater ecosystems. However, the degree to which freshwater populations can acclimate to long-term warming and the underlying molecular mechanisms are not yet fully understood. We used the cooling water discharge (CWD) area of a power plant as a model for long-term warming.

Model of trauma-induced coagulopathy including hemodilution, fibrinolysis, acidosis, and hypothermia: Impact on blood coagulation and platelet function.

Background: Trauma-induced coagulopathy (TIC) is commonly seen among patients with severe injury. The dynamic process of TIC is characterized by variability of the features of the disease.

Methods: A model of TIC was created.