6 results match your criteria: "I.P. Pavlov Saint Petersburg State Medical University[Affiliation]"

[On the histo- and morphogenesis of sclerosing pneumocytoma and its diagnostic criteria].

Arkh Patol

April 2019

Research Institute of Pulmonology, Acad. I.P. Pavlov Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia, Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, St. Petersburg, Russia, P.A. Bayandin Murmansk Regional Clinical Hospital, Murmansk, Russia.

The paper presents the data available in the literature on the pathogenesis, clinical and morphological, histological and immunohistochemical features of pulmonary sclerosing pneumocytoma (SP). The paper gives the detailed histological and immunohistochemical characteristics of 6 SP cases. The need for the differential diagnosis of SP is determined by the features and complexity of their histo- and morphogenesis within a single tumor and a complex diagnostic study.

View Article and Find Full Text PDF
Article Synopsis
  • The study examines the underlying mechanisms and clinical implications of diffuse toxic goiter, specifically looking at proteins related to cell growth and survival in the thyroid.
  • Researchers evaluated 24 women who had surgery, measuring the expression of various proteins linked to proliferation and apoptosis using detailed immunohistochemical tests.
  • Findings suggest that high levels of the anti-apoptotic protein Bcl-2 and the proliferation marker Ki-67 significantly correlate with the risk of developing postoperative thyrotoxicosis, with high predictive accuracy.
View Article and Find Full Text PDF

Aim: To analyze cases of complement-mediated thrombotic microangiopathy (C-TMA) in the daily practice of a hospital nephrology department, relative to the general aspects of the clinical course, therapy, and short-term outcomes.

Subjects And Methods: The prospective study conducted in the period June 1, 2015 to June 1, 2016 included 10 patients with C-TMA newly diagnosed during hospitalization. Standard demographic parameters, generally accepted clinical data showing the severity of TMA and the involvement of vital organs were recorded at admission.

View Article and Find Full Text PDF

Aim: To analyze the efficiency of the ALL-2009 protocol (ClinicalTrials.gov NCT01 193933) in patients with T-cell leukemias, particularly the role of autologous hematopoietic stem cell transplantation (auto-HSCT) after non-myeloablative BEAM conditioning, followed by maintenance therapy.

Subjects And Methods: Since 2009, the ALL-2009 study has enrolled 90 patients with T-cell acute lymphoblastic leukemia (T-ALL), the treatment results were assessed in 86 patients: 6 and 28 patients underwent allogeneic HSCT and auto-HSCT, respectively.

View Article and Find Full Text PDF

[Pharmacoeconomics of ulcers: a view from Saint-Petersburg].

Eksp Klin Gastroenterol

April 2003

Laboratory of Pharmacoepidemiology and Pharmacoeconomy, Institute of Pharmacology, I.P. Pavlov Saint Petersburg State Medical University.

Only in Saint Petersburg the application of omeprazole, hiconcil and fromilid in the treatment of adult patients with duodenal ulcer could save up to 26 million rubles per year due to the decrease in the number of recurrences. Yet these funds are still wasted with the persistence worthy of better application, since most general practitioners do not realize either economic or even clinical value of eradication. The above-mentioned calculations provide a ground for reflections on the improvement of methods of advanced training for specialists with the use of pharmacoepidemiological and pharmacoeconomic grounds for the selection of optimum remedies for the treatment of duodenal ulcer.

View Article and Find Full Text PDF

Myocardial viability in patients with coronary artery disease and heart failure was assessed by echocardiography with low doses of dobutamine and positron emission tomography with Sodium 11C-butyrate. Sensitivity and specificity of those methods were compared. Positron emission tomography and Sodium 11C-butyrate had quite high sensitivity and specificity, which could be compared with positron emission tomography and fluorine-18-deoxyglucose.

View Article and Find Full Text PDF