4 results match your criteria: "I.P. Pavlov Ryazan State Medical University of the RF Ministry of Public Health[Affiliation]"
[Study of gene expression in patients with peripheral artery disease].
Angiol Sosud Khir
January 2022
I.P. Pavlov Ryazan State Medical University of the RF Ministry of Public Health, Ryazan, Russia.
Article Synopsis
- - Current techniques for predicting peripheral artery disease (PAD) are unreliable, highlighting a need for better risk assessment tools, including genetic tests.
- - The article explores the potential of studying gene expression in PAD patients as a promising method to understand disease onset and progression.
- - It includes a review of existing methods for gene expression analysis, evaluates DNA chips, and discusses current challenges in this area of research.
Aim: This study was aimed at determining Bcl-2 and Bax proteins expression before and after reconstructive-repairing operations in patients with atherosclerosis obliterans of lower extremities and at assessing the effect of an antioxidant (vitamin E at a dose of 100 mg once daily for 1 month after surgery) on the dynamics of changes of Bcl-2 and Bax proteins in the postoperative period.
Patients And Methods: The study included a total of 60 patients with stage III-IV lower limb atherosclerosis obliterans. All patients underwent reconstructive-repairing operations on the arteries of the aortofemoral segment.
Aim: The purpose of the study was to determine the level of substances damaging the vascular endothelium, as well as to assess their effect on the functional state of the endothelium and the course of obliterating atherosclerosis of lower limb arteries.
Patients And Methods: The study included a total of 112 people, subdivided into three groups: those with an unfavourable course of obliterating atherosclerosis of lower limbs arteries (n=48) - group 1, patients with obliterating atherosclerosis of lower limbs arteries with a conventionally favourable course (n=48) - group 2, and apparently healthy volunteers (n=16). In all subjects, the following parameters were analysed: stable metabolites of nitric oxide II, endothelin-1, homocysteine and basal insulin.
Aim: The purpose of this study was to specify the anatomy of the deep femoral artery and deep femoral vein within the femoral triangle.
Material And Methods: The study was based on the data of anatomical dissection of vessels in the area of the upper third of the femur (20 specimens ) and ultrasonographic duplex angioscanning of patients undergoing routine examination of the vascular system (40 patients, 50 lower extremities). Ultrasonography was performed using linear and convex transducers (frequency 3-13 and 3-5 MHz).