[Dose-dependent effects of melatonin on the functioning of the cardiovascular system and on the behavior of normotensive rats of different ages.].

The purpose of the work on normotensive rats of different age groups (3, 15 and 22 months) to study the synchronism between the functioning of the cardiovascular system and the locomotor activity of animals in the «open field» test by a single injection of exogenous melatonin in different doses (1 and 10 mg/kg). Studies have revealed the unidirectional dose-dependent effect of exogenous melatonin on the locomotor activity of rats of different ages and the age-dependent effect of melatonin on the parameters of the cardiovascular system. It shows the possibility desynchronization of the circadian rhythms of locomotor activity and the functioning of the cardiovascular system with aging, which can lead to a discrepancy between hemodynamic parameters and the level of locomotor activity.

Clinical substantiation of the sparing and less invasive implant prosthetics of the edentulous lower jaw method.

Objective: Proof of the effective implant prosthetics treatment of patients with the edentulous lower jaw by minimally invasive method.

Materials And Methods: As a sample of clinical research, 68 senior patients (30 men and 38 women) were diagnosed with edentulous lower jaws. The methods of the study included estimating the implant retention by frequency-resonance analysis of Osstell ISQ, the degree of retention and stabilization of the tissue supported and implant-supported dentures (author's method: patent for invention No.

Chemokine Receptors CXCR3 and CCR6 and Their Ligands in the Liver and Blood of Patients with Chronic Hepatitis C.

We performed a comprehensive analysis of CCR6 and CXCR3 chemokine receptors and their ligands CCL20/MIP-3α, CXCL9/MIG, CXCL10/IP-10, and CXCL11/ITAC in the liver and blood of patients with chronic hepatitis C at different stages of the disease. TaqMan PCR was used to determine mRNA gene expression of chemokines and their receptors in liver specimens, xMAP multiplex analysis was performed to estimate the concentration of chemokines in blood plasma, and fl ow cytofluorometry was used to evaluate CCR6 and CXCR3 expression on peripheral blood lymphocyte populations. In the liver of patients with hepatitis C, mRNA expression of CXCL10, CCR6, and CXCR3 genes increases with fibrosis progression in the liver tissue.