[Rehabilitation of hearing impaired elderly patients by means of hearing aids with frequency lowering technology.].

The objective of this study was to assess the effectiveness of rehabilitation of hearing impaired elderly patients using hearing aids with frequency lowering technology called Frequency Composition ™. 23 hearing aid users (mean age 64 years) with moderate to severe sensorineural hearing loss were tested. All participants were divided into two groups according to configuration of audiogram: 11 people with averaged slope of 27,9 dB per an octave within frequency range of 1-2 kHz (the 1st group) and 12 people with slope of 24,1 dB at 2-4 kHz (the 2nd group).

[Personified monitoring of acute coronary syndrome and its outcomes in elderly patients. Report 2. Invasive diagnostic and treatment methods (review).].

Literature review describes the features of diagnosis and monitoring of elderly and senile patients with coronary heart disease, that will undergoing coronary angiography, percutaneous coronary intervention or coronary artery bypass surgery. Review notes the advantage of the routine invasive strategy in elderly patients with a high risk of NSTEMI. The authors recommend a preliminary assessment of frailty before coronary angiography.

[Clinical features of inflammatory bowel disease (ulcerative colitis and Crohn's disease) in geriatric practice in Saint Petersburg.].

Objective - to identify the clinical features of inflammatory bowel disease (IBD) in elderly and senile patients in St. Petersburg. A retrospective analysis of medical charts of 208 patients over 60 years old with inflammatory bowel diseases (IBD) was carried out: 60% of them with ulcerative colitis (UC), 40% with Crohn's disease (CD).

[Personified monitoring of acute coronary syndrome and its outcomes in elderly patients. Report 1. Acute coronary syndrome (overview).].

The overview describes the clinical features of acute coronary syndrome in patients of older age groups. Atypical symptoms present in this cohort very often. It associated with a worse prognosis, partly due to delays in diagnosis, treatment, and insufficiently substantiated drug therapy.

[Allergic rhinitis in the pregnant women].

The objective of the present work was to elucidate the specific features of the clinical picture of allergic rhinitis in the pregnant women. The study included 156 pregnant women presenting with the persisting form of the disease and 63 patients having its intermitting form. The character of the endoscopic manifestations of rhinitis, chronic tonsillitis, and gastroesophageal reflux was evaluated with the use of a scoring system.

Therapeutic Apheresis in Metabolic Syndrome.

Background: The metabolic syndrome unites three pathologies of the person - obesity, arterial hypertension and diabetes. In recent years the progressing of such distribution covering from 2.5% to 3.

[Operational management of the state forensic medical expert activity in Russia as a scientific problem: brief history analyzed and prospects for further studies].

The authors consider and systematize the methods currently in use for the purpose of operational management of the state forensic medical expert activity (FMA) in Russia throughout the entire historical period since the establishment and development of the forensic medical expertise service in this country as well as the prospects for its further improvement. The importance of the problem arises from the fact that the legal status of the forensic medical expertise in the Russian Federation remains a matter of scientific discussions. On the one hand, some experts consider it necessary to set up on a broader basis forensic medical facilities of a new type as an alternative to the existing governmental bodies.

[The analysis of the association of the polymorphic variants of the TPMT, COMT, and ABCC3 genes with the development of hearing disorders induced by the cisplatin treatment].

Cisplatin and its derivatives are widely used chemotherapeutic agents for the treatment of many cancers, including hepatoblastoma, brain tumors, and germ-cell tumors. This therapy contributed to the dramatic increase in the survival rate. However, its use is restricted by the high incidence of irreversible ototoxicity associated with cisplatin application (in more than 60% of the children receiving it).

[The application of the screening questionnaires for the diagnostics of the central auditory processing disorders in the pediatric practice].

Identification and diagnostics of auditory processing disorders (APD) in the children continues to be a challenge. Screening tools help to decide the need for evaluation. However, none of them are used routinely in Russia, nor are there thus far auditory checklist questionnaires in the Russian language.

[The patulous Eustachian tube syndrome: the current state-of-the-art and an original clinical observation. Second communication].

The choice of the treatment strategy for the patients presenting with the patulous Eustachian tube syndrome constitutes a serious challenge for an otorhinolaryngologist. Despite the considerable progress achieved during the past years in the development of modern pharmacotherapy and functional endoscopic surgery, the specialists often encounter difficulties in the management of the patients suffering from this disease. The present article (continuing the previous communication) contains information concerning the historical and modern approaches to the treatment of the patients with the patulous Eustachian tube syndrome.

[The patulous Eustachian tube syndrome: the current state of the problem and our own clinical observation. Part 1].

The patulous Eustachian tube syndrome was described more than 150 years ago, but up to the present time some of its aspects continue to be a challenge for both fundamental and clinical medicine. Certain issues of etiology and pathogenesis of this condition have until recently remained unclear which probably accounts for the failure of choosing the adequate methods for its medical correction. Despite the seemingly broad spectrum of the modern tools for the purpose including first and foremost the endoscopic and radiological techniques, verification of the patulous Eustachian tube may encounter difficulties for the specialists.

[The influence of central auditory processing on the intelligibility of the speech in the patients presenting with hearing impairment].

The objective of the present study was to evaluate to what degree the function of the central auditory pathways influences the intelligibility of the speech in the patients suffering from the sensorineural loss of hearing (SNLH). The study included a total of 20 patients at the age varying from 31 to 80 years presenting with moderate to moderately severe symmetrical SNLN. All the patients were permanent hearing aid users.

[The expert characteristic of the forensic medical documentation for the purpose of investigations of the injuries to the maxillofacial region].

The injuries to the maxillofacial region (MFR) are among the most frequently occurring problems encountered if the forensic medical practice. The objective of the present study was the analysis of the quality of the medical record documentation of the victims of the injuries to the maxillofacial region for obtaining the information necessary for forensic medical experts to make the well-founded conclusions. We undertook the in-depth analysis of random samples from the materials stored in the archive of living subjects at the Saint-Petersburg Bureau of forensic medical expertise for the period from 2010 to 2014.

[Visualization of the reconstruction of a criminal event by means of 3D-modeling].

Forensic medical expertise carried out with a view to reconstruction of an event is a time-consuming procedure because it requires collection of a large amounts of various materials for the institution of a criminal investigation including physical evidence, photoboards of the site of an occurrence, etc. A forensic medical expert may encounter difficulties when reconstructing and scrutinizing the scene of action at a single computer monitor in order to analyze the behaviour of each participant of the event. Of great help in such situations are modern software programs allowing to visualize the site of an occurrence with a maximum approximation to reality, simulate the actions of the victim(s) and alleged offender(s), perform a large number of other forensic studies.

[The construction of the three-dimensional model of the damaged bone tissue based on its roentgenogram].

The objective of the present work was to develop the method for the visualization of the shape of the bone surface in the region of its traumatic damage based on the results of the analysis of a single X-ray image for the solution of the problems facing forensic medical expertise and traumatology. The three-dimensional models of the fractures of the long tubular bones constructed with the use of the visualization technique were shown to adequately reproduce the morphological picture of the injury. It allowed to enhance the potential of the forensic medical analysis and the accuracy of the diagnostic methods employed for the purposes of forensic medical expertise.

[The peculiar morphological features of the surface relief of the major local ruptures of the liver in the case of a blunt injury].

The objective of the present study was the comprehensive investigation of morphogenesis of the surface relief of the major local ruptures of the liver in the case of a blunt injury and the obtaining of an additional information on the possibility to use these data for the purposes of forensic medical expertise. We explored the reliefs of the major local ruptures of the liver in the cases of a single fatal blunt injury inflicted in a traffic accident, by kicking or a powerful stroke with the fist. In addition, the threshold hepatic lesions depending on their severity were determined experimentally.

[The forensic medical evaluation of the injuries inflicted inside the passenger compartment of a moving car equipped with the modern personal safety systems].

The objective of the present study was to elucidate the characteristic features of the injuries inflicted to the victims of a road traffic accident inside the passenger compartment of a moving car equipped with the modern personal safety systems. The materials available for the present work included the lesions documented in 210 drivers and 150 occupants of the car passenger compartments. Both comparative, morphometric and statistical methods were used to analyze the data obtained.

[The characteristic features of vertebral lesions in the victims of a road traffic accident with intrusion into the passenger car compartment].

The objective of the present study was to develop the diagnostic criteria for determining the positions of the participants of a road traffic accident inside the passenger car compartment based on the analysis of the characteristic features of vertebral lesions in the victims. The archival documents of forensic medical expertises were used to analyze the specific characteristics of fractured cervical vertebra in the victims of the accident inside the passenger car compartments including the drivers (n=92), the occupants of the forward (n=43) and rear (n=37) seats of the car. Localization and mechanisms behind the formation of vertebral lesions in the cervical part of the spinal column associated with the intra-compartment injury is of primary importance for the diagnostic purposes.

[Age related aspects of cochlear implantation.].

The objective of this study was to assess the long-term results of cochlear implantation in terms of age-related changes. 67 patients of different age with chronic bilateral severe sensorineural hearing loss and deafness with experience of use of cochlear implants (CI) for at least 5 years were tested. The 1st group included young patients (25,5±7,9 years), the 2nd group - middle-aged (51,4±5,4 years), the 3rd group - elderly patients (67±5,6 years).

[The forensic medical evaluation of the changes in the cerebral tissue in the case of sudden death from alcoholic cardiomyopathy].

This article presents the results of the retrospective analysis of the protocols of forensic medical autopsies and histological studies of the cerebral tissues together with the data obtained by their statistical treatment. The objective of present work was to study and evaluate the structural changes in the cerebral tissues associated with sudden cardiac death from alcoholic cardiomyopathy. It was shown that the morphological changes in the endothelial lining of the microcirculatory bed of the cerebral tissue can be a consequence of both the direct cytotoxic action of ethanol or its metabolites and the influence of cellular modulators liberation of which results in enhanced vascular permeability associated with trophic disturbances in the tissue.

[The effectiveness of the combination of azelastine hydrochloride and mometasone furoate for the intranasal application in the patients presenting with seasonal allergic rhinitis].

The objective of the present work was to evaluate the effectiveness of the combination of azelastine hydrochloride and mometasone furoate for the intranasal application to treat the patients presenting with seasonal allergic rhinitis. A total of 60 subjects suffering from seasonal allergic rhinitis were available for the observation. All the patients were allocated to three groups comprised of 20 individuals each.

[The specific features of corpse putrification under the influence of necrobiome enzymatic systems].

The objective of the present study was to characterize the specific features of corpse putrification under the influence of necrobiome enzymatic systems depending on the duration of the post-mortem period. We present the results of investigations into the enzymatic activity of the dominant species of microorganisms making up the post-mortem microbiome. The domestic pork carcasses weighing 50-70 kg were used as an experimental putrification model.

[Adult B-cell acute lymphoblastic leukemias: Conclusions of the Russian prospective multicenter study ALL-2009].

Aim: To analyze the efficiency and reproducibility of the ALL-2009 protocol within the Russian prospective multicenter study based on different principles of cytostatic effects (non-intensive, but continuous cytotoxic treatment and a small number of allogeneic hematopoietic stem cells).

Subjects And Methods: The ALL-2009 (NCT01193933) study conducted in April 2009 to December 2016 included 194 patients (95 males and 99 females) aged 15 to 55 years (median age 28 years) with Ph-negative B-cell acute lymphoblastic leukemia (ALL). There was early pre-B-cell ALL in 54 patients, common ALL in 101, pre-B ALL in 39, initial leukocytosis in 9.

[The peculiarities of the relationship between the effector cells of the local immune system in the broncho-vascular barrier of the breast-fed infants presenting with certain acute respiratory viral infections].

Unlabelled: The acute respiratory viral infections (ARVI) are ranked among the most widespread diseases affecting the children in the early infancy. They account for 60 to 85.4% of all infections recorded in the young children.

[Membranous nephropathy in a Russian population].

Aim: To analyze the clinical and morphological manifestations of membranous nephropathy (MN) and to evaluate the efficiency of its therapy.

Material And Methods: MN cases in 2009 to 2016 were retrospectively detected with a subsequent analysis of patients with primary MN (PMN). The titer of IgG-autoantibodies to phospholipase A2 receptor (anti-PLA2R Ab) was determined by an indirect immunofluorescence assay.