Investigations of potent biocompatible metal-organic framework for efficient encapsulation and delivery of Gemcitabine: biodistribution, pharmacokinetic and cytotoxicity study.

Gemcitabine (GEM), a nucleoside analogue, is used for the treatment of various cancers. However, this drug possesses several limitations such as poor pharmacokinetics, metabolic degradation by cytidine deaminase, development of drug resistance, and schedule dependent toxicity. To circumvent these drawbacks, it can be entrapped in a suitable formulation for protection against metabolic degradation or urinary excretion.

Formulation optimization and characterization of transdermal film of curcumin by response surface methodology.

Objective: India is referred as goldmine of herbal drugs but still lack of optimization of herbal drugs, which has kept us on the back foot. The rationale of the study is to prepare optimized transdermal drug delivery system of curcumin employing response surface methodology to study the collective effect of independent variables like concentration of ethyl cellulose, hydroxyl propyl methyl cellulose and dibutyl phthalate which significantly influenced characteristics like percentage elongation and drug release.

Method: Twenty formulations containing varying concentrations of polymers and permeation enhancer were prepared using solvent casting technique.

Oleic Acid Vesicles as a new Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar rats.

Background: Cutaneous candidiasis is a deep-seated skin fungal infection that is most commonly observed in immunocompromised patients. This fungal infection is conventionally treated with various formulations like gels and creams which are having different side effects and least therapeutic efficacy. Hence, it becomes necessary to develop a novel carrier system for the treatment of this deep-seated skin fungal infection.

Plants Used as Antihypertensive.

Hypertension is a critical health problem and worse other cardiovascular diseases. It is mainly of two types: Primary or essential hypertension and Secondary hypertension. Hypertension is the primary possibility feature for coronary heart disease, stroke and renal vascular disease.

Resveratrol-loaded folate targeted lipoprotein-mimetic nanoparticles with improved cytotoxicity, antioxidant activity and pharmacokinetic profile.

The aim of present study was to develop folate receptor targeted lipoprotein-mimetic nanoparticles of resveratrol (RSV). Lipoprotein-mimicking nanocarrier (RSV-FA-LNPs) comprising of phosphatidyl choline, cholesterol, stearyl amine and folic acid-tagged bovine serum albumin (FA-BSA) were prepared. Folic acid was conjugated to bovine serum albumin by amide bond at a binding rate of 9.

The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic.

Purpose Of Review: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is identified from Wuhan, China, and has spread almost worldwide. Recently, the newly identified SARS-CoV-2 has been confirmed to kill millions of people worldwide and is dangerous to society health, survival, and livelihood. The people with cardiovascular problems are noticed as most common patients of coronavirus disease 2019 (COVID-19).

3D scanning of a carburetor body using COMET 3D scanner supported by COLIN 3D software: Issues and solutions.

Nowadays, the industry uses 3D Scanners for reverse engineering, new product design, rapid manufacturing, multimedia, architecture, inspection, and quality control. The scanning process converts a real object into a digital format. This paper's essential purpose is to show the use of a 3D blue light Scanner/COMET 3D to redesign a carburetor body.

Study of ARIMA and least square support vector machine (LS-SVM) models for the prediction of SARS-CoV-2 confirmed cases in the most affected countries.

Discussions about the recently identified deadly coronavirus disease (COVID-19) which originated in Wuhan, China in December 2019 are common around the globe now. This is an infectious and even life-threatening disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has rapidly spread to other countries from its originating place infecting millions of people globally.

Correction to: Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats.

The original version of this article unfortunately missed to include the other affiliation of the first author Rimpi Arora as listed below.

Redefining diabetic foot disease management service during COVID-19 pandemic.

Background & Aims: Diabetic Foot Disease (DFD) management had to be redefined during COVID-19. We aim to evaluate the impact of this on diabetic foot care services and the strategies adopted to mitigate them.

Methods: We have performed a comprehensive review of the literature using suitable keywords on the Search engines of PubMed, SCOPUS, Google Scholar and Research Gate in the first two weeks of May 2020.

Transcending the Cutaneous Barrier Through Nanocarrier Exploration for Passive Delivery of Anti-hypertensive Drugs: A Critical Review.

Background: Hypertension comes under the category of chronic disease, which requires long term treatment. Hypertension is usually treated by oral administration of various therapeutic agents. There are several limitations of the oral route, making pharmaceutical scientists to discover an alternative route for drug delivery.

CpGDB : A Comprehensive Database of Chloroplast Genomes.

Chloroplast Genome Database (CpGDB) is user friendly, web-based, freely available and dynamic relational database which provides a platform for researchers to search and download complete chloroplast genome sequences, individual gene sequences and feature records of plant species belonging to same or different families of spermatophytes. Presently, the database consists of genome sequences, individual gene sequences and feature records of chloroplast genomes of 3823 plant species belonging to 1527 genera from 256 families, which will be updated regularly with the availability of new sequences at NCBI. Extensive data mining of feature records from GenBank files, uniform nomenclature for majority of genes, enriched intron/exon feature records makes CpGDB a valuable resource for studies in chloroplast genomics while complementing existing chloroplast databases.

Development of new hybrid model of discrete wavelet decomposition and autoregressive integrated moving average (ARIMA) models in application to one month forecast the casualties cases of COVID-19.

Everywhere around the globe, the hot topic of discussion today is the ongoing and fast-spreading coronavirus disease (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Earlier detected in Wuhan, Hubei province, in China in December 2019, the deadly virus engulfed China and some neighboring countries, which claimed thousands of lives in February 2020. The proposed hybrid methodology involves the application of discreet wavelet decomposition to the dataset of deaths due to COVID-19, which splits the input data into component series and then applying an appropriate econometric model to each of the component series for making predictions of death cases in future.

Challenges and solutions in meeting up the urgent requirement of ventilators for COVID-19 patients.

Background: Severely affected patients in the COVID-19 pandemic need Ventilators, we chart the challenges faced by the health care systems in procuring these machines and the role of 3-D printing technology in building ventilators.

Aims: We tried to find the current role, availability and need of ventilators in the COVID-19 pandemic and the role of applied innovative technologies is assessed.

Methods: We have done a comprehensive review of the literature using suitable keywords on the search engines of PubMed, SCOPUS, Google Scholar and Research Gate in the second week of April 2020.

Sustainability of Coronavirus on Different Surfaces.

Coronavirus disease 2019 (COVID-19) is the name of the disease supposedly manifested in December 2019 from Wuhan, from the virus named SARS-CoV-2. Now, this disease has spread to almost all other parts of the world. COVID-19 pandemic has various reasons for its dramatic worldwide increase.

Industry 4.0 technologies and their applications in fighting COVID-19 pandemic.

Background And Aims: COVID 19 (Coronavirus) pandemic has created surge demand for essential healthcare equipment, medicines along with the requirement for advance information technologies applications. Industry 4.0 is known as the fourth industrial revolution, which has the potential to fulfil customised requirement during COVID-19 crisis.

Recent Advances in Nanotherapeutic Interventions for the Treatment of Alzheimer's Disease.

Alzheimer's disease (AD), with impairment of learning and memory as the common clinical manifestations, is one of the most challenging diseases affecting individuals, their families and society as a whole. The fact that its prevalence is escalating rapidly, with the total number of AD patients estimated to reach 115.4 million by 2050, has made the disease a very challenging ailment worldwide.

Synthesis, characterization, and visible-light-induced photocatalytic activity of powdered semiconductor oxides of bismuth and zinc toward degradation of Alizarin Red S.

Semiconductor oxides of bismuth and zinc have been synthesized using modified sol-gel method and sol-combustion method, respectively. The synthesized catalysts were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and UV-vis spectroscopy. The photocatalytic activity of Bi O and ZnO was evaluated for the degradation of Alizarin Red S (ARS), as a model pollutant, at 20 mg/L level in water under visible light irradiation.

Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy.

Occurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immunocompromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Although, a large number of antifungal agents are available for treatment of skin fungal infections, but, their toxic profile and physicochemical characteristics reduce therapeutic outcome.

Integrating Morphological Edge Detection and Mutual Information for Nonrigid Registration of Medical Images.

Background: Medical images are widely used within healthcare and medical research. There is an increased interest in precisely correlating information in these images through registration techniques for investigative and therapeutic purposes. This work proposes and evaluates an improved measure function for registration of carotid ultrasound and magnetic resonance images (MRI) taken at different times.

Development and optimization of nanoemulsion based gel for enhanced transdermal delivery of nitrendipine using box-behnken statistical design.

The purpose of present research was to develop and statistically optimize nitrendipine nanoemulsion gel for transdermal delivery using box-behnken statistical design. The nanoemulsion formulations bearing nitrendipine were prepared by application of ternary phase diagram and spontaneous emulsification method. Box-behnken design was employed for the optimization of nitrendipine loaded nanoemulsion.

Heterocyclic Compounds Bearing Triazine Scaffold and Their Biological Significance: A Review.

Benzene is a six-membered hydrocarbon ring system and if three carbon-hydrogen units of benzene ring are replaced by nitrogen atoms then triazine is formed. Triazines are present in three isomeric forms 1,2,3- triazine, 1,2,4-triazine, and 1,3,5-triazine according to the position of the nitrogen atom. These are weak bases having weaker resonance energy than benzene, so nucleophilic substitution is preferred than electrophilic substitution.

Parametric optimization of deep cryogenic treatment for the wear response of implant material UNS R56700: Taguchi's approach.

Using the Taguchi's robust design of experiments methodology, this article presents the systematic identification and optimization of most influential parameters of deep cryogenic treatment process to minimize the specific wear rate of UNS R56700 (Ti6Al7Nb). In addition to the different soaking durations (0-96 h) at 77 K and different tempering temperatures (room temperature, 403-523 K), three commonly used variables of pin-on-disk test, namely, sliding speed (1.047-2.

Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress.

Background: Anxiety is a disorder of multi-factorial pathogenesis involving interrelated pathways of neurotransmitters, oxidative stress and metamorphosed calcium-signaling that negatively affects brain functions. Modulation of Ca-channels outlines a promising strategy to curb the progression of anxiety-like disorders through attenuation of redox-imbalance. The current research scheme was designed to explore the anxiolytic effects of lacidipine (L-type Ca-channel blocker; LCD) pretreatment in caffeine-induced anxiety-like symptom model in mice.