[Physical rehabilitation for ankle joint injuries in the elderly and senile (stage 3).].

Ankle injuries are among the most common musculoskeletal injuries in the elderly. However, among the new scientific publications, both foreign and domestic, there are almost no examples and algorithms for conducting rehabilitation exercises for elderly patients, which prevents the introduction of these practices into rehabilitation measures. The purpose of our study is to evaluate the created technique of physical rehabilitation and, with a reliable result, to introduce it into the daily work of doctors of various profiles who provide assistance to patients with ankle joint injuries.

[A new screening method for the diagnosis of sarcopenia in people 65 years and older.].

Diagnosis of sarcopenia is difficult due to the limitations of measuring muscle mass, which requires specialized equipment. Simple screening tools can be useful in general practice. The aim of the study was to develop a new screening method for diagnosing sarcopenia based on risk factors and biomarkers of the disease.

Dual Adeno-Associated Virus 9 with Codon-Optimized DYSF Gene Promotes In Vivo Muscle Regeneration and May Decrease Inflammatory Response in Limb Girdle Muscular Dystrophy Type R2.

Dysferlinopathy treatment is an active area of investigation. Gene therapy is one potential approach. We studied muscle regeneration and inflammatory response after injection of an AAV-9 with a codon-optimized DYSF gene.

[Physical rehabilitation for ankle joint injuries in elderly and elderly people (Stage 2).].

The main part of the injuries of elderly and senile patients as a result of physical activity falls on the lower limbs, due to the increased load during movement. Ankle injuries have a multifactorial etiology involving the interaction of compensatory spinal and leg biomechanics, environmental factors, and shoe selection. In this regard, it is necessary to prepare a complex of rehabilitation measures, including physical therapy, with the possibility of implementing the recovery process not only on an outpatient basis, but also at home, thereby improving the quality of life and preventing disability.

[Physical rehabilitation for ankle joint injuries in elderly and elderly people (Stage 1).].

A multidisciplinary approach to recovery after injuries of the ankle joint in elderly and senile people by specialists of various profiles using drug and non-drug methods is especially relevant today. It is required to develop and put into practice various options for the combined use of physical rehabilitation means at different stages of the rehabilitation treatment of elderly and senile patients with this pathology. The study revealed no significant complications and side effects when using this technique, which allows us to recommend it as a means of secondary prevention and injuries of the ankle joint, especially with contraindications to the use of non-steroidal anti-inflammatory drugs and glucocorticosteroids.

In Vivo DYSF Gene Viral Delivery Provides a Histoprotective Effect in Skeletal Muscle Tissue in Dysferlin-Deficient Mice.

We studied the effects of a dual-vector DYSF gene delivery system based on adeno-associated virus serotype 9 capsids on pathological manifestations of dysferlinopathy in skeletal muscles of Bla/J mice lacking DYSF expression. The mice received intravenous injection of 3×10 genomic copies of the virus containing the dual-vector system. M.

[Comprehensive analysis of the efficacy of personalized rehabilitation programs in patients with breast cancer].

Unlabelled: The concept of the personalized rehabilitation is based on the principle of applying physical and rehabilitative medicine techniques depending on the factors that mostly influence on rehabilitation efficacy in a particular patient - determinant of effectiveness. Current achievements in the diagnosis and treatment of breast cancer (BC) significantly increased overall patients' life expectancy, updating rehabilitative treatment stage, which is often unmet.

Objective: To perform the comprehensive analysis of the efficacy of personalized rehabilitation programs in patients with BC.

[Medical rehabilitation of patients with spinal muscular atrophy].

Unlabelled: Rehabilitation of patients with spinal muscular atrophy (SMA) is a long-term strategy of healthcare service of Russian Federation, which is aimed at slowing down the progression of the pathological process, maximal reduction of disability and improving patients' quality of life. The development of targeted programs of medical rehabilitation for patients with SMA, aimed at the reduction of the disease's main symptoms, is relevant.

Objective: To develop and scientifically establish therapeutic effects of complex medical rehabilitation of type II and III SMA patients.

[Physical rehabilitation for degenerative-dystrophic diseases of the hip joint in elderly and senile people (stage 1).].

Changes in the age structure of the planet's population are leading to an increase in the number of geriatric patients requiring replacement of large joints. Age-related weakness, loss of muscle mass, testosterone deficiency, excess weight, and the presence of concomitant diseases make the process of rehabilitation treatment labor-intensive and lead to various complications. The purpose of our work was to evaluate the effectiveness of the modernized method of physical therapy at the first stage of rehabilitation treatment in elderly and senile patients with osteoarthritis of the hip joint.

Evaluation of the Content of Aquaporin-5 and Epithelial Sodium Channel in the Lungs of Rats during the Development of Toxic Pulmonary Edema Caused by Intoxication with Acylating Pulmonotoxicants.

We studied the content of aquaporin-5 (AQP) and epithelial sodium channel (ENaC) in rat lungs during the development of toxic pulmonary edema (TPE) caused by intoxication with phosgene and perfluoroisobutylene (1.5 LC). The lung body weight index (LBI) was calculated and histological examination of the lung tissues was performed.

[Physical rehabilitation for osteochondrosis of the cervical and thoracic spine in elderly and senile people (Stage 3).].

The concept of a multidisciplinary approach to the treatment of osteochondrosis in elderly and senile patients by specialists of various profiles using medicinal and non-medicinal methods is especially relevant today, therefore, it is necessary to develop and put into practice various options for the combined use of physical rehabilitation means at different stages of rehabilitation treatment of elderly and senile patients with osteochondrosis of the cervical and thoracic spine. The dynamics of clinical manifestations of osteochondrosis after rehabilitation treatment relative to the age of patients in groups showed that the effectiveness of the technique is much higher in elderly patients, in contrast to senile patients and centenarians. The study revealed no significant complications and side effects when using this technique, which allows us to recommend it as a means of secondary prevention of diseases of the cervical and thoracic osteochondrosis, especially in the presence of contraindications to the use of non-steroidal anti-inflammatory drugs and glucocorticoids.

[Optimization of rehabilitation of elderly and senile patients with primary traumatic dislocation of the shoulder.].

Тhe aim of the study is to improve the treatment outcomes of elderly patients with primary traumatic shoulder dislocation by developing an atraumatic rehabilitation method. The study included 56 patients aged over 60 years with primary traumatic dislocation of the shoulder. The patients of the first group (29 patients) after the dislocation of the shoulder was corrected, functional treatment was performed using orthoses and a developed course of physical therapy.

[Physical rehabilitation for osteochondrosis of the cervical and thoracic spine in elderly and senile people (Stage 2).].

The main and most frequently used means of physical rehabilitation for osteochondrosis of the cervical and thoracic spine is motor rehabilitation. The goals of physical rehabilitation of persons suffering from osteochondrosis are to strengthen the muscles of the back, reduce the load on the intervertebral discs, improve blood circulation, restore a normal motor stereotype and, as a result, reduce pain. The use of means of motor rehabilitation is scientifically substantiated, the mechanisms of their effect on the functional state of the body have been studied, and the effectiveness of their use is beyond doubt.

[Evaluation of the effectiveness of the third stage of rehabilitation after a knee joint injury in persons of older age groups by means of physiotherapy exercises.].

The main task in the rehabilitation of athletes with traumatic injuries of the knee joint and surrounding soft tissues is effective and painless recovery at all stages of treatment. The aim of this work is to introduce a set of physical exercises for the treatment and prevention of traumatic injuries of the knee joint in middle-aged and elderly patients at the third stage of rehabilitation treatment (ICD-10: S80-S89). To date, there is no single regulated program for the management of middle-aged and elderly patients at the outpatient stage.

[Evaluation of the efficiency of therapeutic gymnastics for knee joint injuries in athletes of the senior age groups.].

The introduction and scientific substantiation of methods for organizing sports events with optimal motor loads for citizens of middle and senior age groups should be based on two principles: general (pedagogical) principles of physical education and sports training, adapted to the specifics of health-related training; analysis of physiological and psychophysiological effects that are created by physical activity of various types and directions in the human body. The importance of this topic is due to the fact that knee injuries occupy a special place in the sports of veterans, and severe injuries and injuries in this area can restrict an athlete in his professional activities. The problem of rehabilitation of athletes of older age groups with knee injuries is not only a medical problem, but also has an important socio-economic significance.

Modeling of Retinal Degeneration.

We developed a model of retinal degeneration in rabbits based on exposure to light with a wavelength of 405 nm. This model allows reproducing structural and functional disorders in the central parts of the retina, including primarily degeneration of the outer layers of the retina (retinal pigment epithelium and layer of photoreceptor cells), and is designed to study the mechanisms of formation, progression and effectiveness of new drugs and methods of treatment of degenerative diseases of the retina.

[Efficiency of rehabilitation in persons of middle and elderly age with knee joint injuries.].

Traumatic injuries of the knee joint of middle and elderly age account for the majority of injuries of the lower limb. There is a large number of developments in the rehabilitation of the knee joint after injuries, but unified approaches to the rehabilitation algorithm have not been formed. The purpose of this work was to evaluate the effectiveness of a set of physical exercises for the treatment and prevention of traumatic injuries of the knee joint in middle-aged and elderly patients (ICD-10: S80-S89).

[Low-pressure pneumoperitoneum with abdominal elevation in laparoscopic radical prosta-tectomy in elderly patients with a localized form of prostate cancer.].

Prostate cancer is an actual problem among males of older age groups, while the concomi-tant premorbid background of this category of patients often leads to the development of postopera-tive complications using the standard surgical method. The article presents the results of using low-pressure pneumoperitoneum with anterior abdominal wall lifting for laparoscopic radical prostatec-tomy in elderly patients with a localized form of prostate cancer. Convincingly shown that the use of low-pressure techniques pneumoperitoneum with lifting anterior abdominal wall ensures satis-factory operating field, obtains stable indicators of operational monitoring and allow to reduce the duration of the operation, as well as reduce the duration of hospitalization and incidence of postoperative complications.

[Age features of bioregulatory therapy of dental diseases.].

The article presents data on the use of peptide bioregulators of cell homeostasis and the protective functions of the body in various dental diseases and pathology of organs and tissues of the maxillofacial region. Issues related to the immunopharmacological effect and clinical use of natural and synthetic peptide thymomimetics (thymalin, thymogen, vilon, epithalamin, cortexin) and peptide bioregulators from cartilaginous (sigumir, chondrolux) and other tissues in case of trauma, as well as inflammatory, inflammatory and other pathological processes of tissues of the oral cavity and maxillofacial region. Particular attention is paid to their use in the complex treatment of dental diseases in the elderly.

[Study of the most significant for the correction components of the functional condition of elderly hockey players.].

Presents the results of a dynamic integrated study of the vegetative, metabolic and psycho-physiological components of the functional state of elderly hockey players before and after participating in competitions. The study involved 42 male hockey players aged 55-64 years. It has been established that the indicators of the vegetative regulation of cardiac activity are the most stable component of the functional state in the group of elderly athletes.

[The role of comprehensive geriatric assessment in the treatment of cancer patients in elderly and senile age.].

Modern approaches to the organization of diagnosis and treatment of elderly and senile patients with malignant tumors allow to maintain the necessary level of health, improve the quality of life and increase life expectancy. Assessment of geriatric status in Oncology allows: to predict complications during the complex treatment, including drug treatment; to modify treatment to reduce the risk factors of adverse outcomes; to select patients for specialized treatment using standard schemes. So, timely assessment of geriatric syndromes and their correction can expand the indications for specialized treatment of elderly and senile patients.

[Myocardial Infarction in the Group of Patients With Atrial Fibrillation].

Prevalence of patients with myocardial infarction (MI) and atrial fibrillation (AF) has been growing every year. These patients represent a highest risk group and, thus, require special attention of clinicians. The article foсused on mechanisms of the AF and MI interaction, special aspects of prediction depending on the type of AF and MI, and the issue of antithrombotic therapy in this patient category.

[Iron deficiency anemia in elderly and senile patients.].

Anemic syndrome is common in 1/3 of the population, including iron deficiency anemia - in 1,5 billion people. Geriatric patients are one of the main risk group for anemia. Iron deficiency and iron deficiency anemia lead to a decrease in quality of life, an increase in morbidity and mortality, what requires timely diagnosis and treatment.

[Association of polyunsaturated fatty acids treatment with coronary mortality. A meta-analysis].

Aim: A meta-analysis was undertaken to sum up data on long-chain polyunsaturated fatty acids treatment and coronary deaths.

Methods: Only studies with no less than 500 participants and length of follow-up no less than one year were included. Total number of studies was 13 with 127455 participants.

[Oral liquid adult: age peculiarities of the physicochemical properties and micro crystallization.].

In 275 (69 men and 206 women) aged 25 to 86 years, including 74 elderly and old people suffering from type 2 diabetes mellitus, chronic nonspecific inflammatory bowel diseases, alcoholism, chronic kidney disease with the use of various laboratory methods, age-specific features of physical and chemical properties and microcrystallization of oral fluid were studied. It is shown that age-related changes in the composition and properties of mixed saliva and the peculiarities of its microcrystallization are due not only to the aging process, but also to concomitant chronic diseases. As you age, with a decrease in salivation in the oral fluid is determined by increasing the total protein content, reducing the Ca/P ratio, as well as increasing its viscosity.