1 results match your criteria: "I. I. Metchnikov Research Institute for Vaccines and Serum[Affiliation]"
Activation of innate immunity by bacterial ligands of toll-like receptors.
Front Immunol
March 2014
Laboratory of Therapeutic Vaccines, I. I. Metchnikov Research Institute for Vaccines and Serum, Russian Academy of Medical Sciences , Moscow , Russia.
Article Synopsis
- Tγδ and B1 lymphocytes quickly respond to mucosal pathogens by producing antibodies, crucial for immediate immune protection without needing extra signals.
- The study examined how different methods (subcutaneous, intranasal, and oral) to deliver the immunomodulator Immunovac-VP-4 affected these lymphocytes, revealing increases in Tγδ and B1 cell levels across various lymphoid tissues.
- Mucosal application of Immunovac-VP-4 not only activated immune responses in local tissues but also enhanced migration of immune cells to distant organs, contributing to both local and systemic immunity.