7 results match your criteria: "Hyvinkää Hospital and Helsinki University Hospital[Affiliation]"
Reactivation of a transplant recipient's inherited human herpesvirus 6 and implications to the graft.
J Infect Dis
May 2024
Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Background: The implications of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) in solid organ transplantation remain uncertain. Although this trait has been linked to unfavorable clinical outcomes, an association between viral reactivation and complications has only been conclusively established in a few cases. In contrast to these studies, which followed donor-derived transmission, our investigation is the first to examine the pathogenicity of a recipient´s iciHHV-6B and its impact on the graft.
View Article and Find Full Text PDFIschemic Stroke Temporally Associated With New-Onset Atrial Fibrillation: A Population-Based Registry-Linkage Study.
Stroke
January 2024
University of Helsinki, Finland (E.K., M. Lehto).
Background: Limited data exist on the temporal relationship between new-onset atrial fibrillation (AF) and ischemic stroke and its impact on patients' clinical characteristics and mortality.
Methods: A population-based registry-linkage database includes all patients with new-onset AF in Finland from 2007 to 2018. Ischemic stroke temporally associated with AF (ISTAF) was defined as an ischemic stroke occurring within ±30 days from the first AF diagnosis.
Optical coherence tomography shows decreased thickness of retinal nerve fibre layer among foetal alcohol exposed young adults in a case-control study.
Acta Ophthalmol
November 2021
Department of Obstetrics and Gynecology, University of Helsinki, Kuopio University Hospital and Helsinki University Hospital, HUS, Finland.
Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis.
Arthritis Rheumatol
November 2021
Università degli Studi di Genova, Istituto Giannina Gaslini, IRCCS and Clinica Pediatrica e Reumatologia, Genoa, Italy.
Objective: To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor-negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist.
Methods: The cutoffs definition cohort was composed of 1,936 patients included in the multinational Epidemiology, Treatment and Outcome of Childhood Arthritis (EPOCA) study. Using the subjective physician rating as an external criterion, 4 methods were applied to identify the cutoffs: mapping, Youden index, 90% specificity, and maximum agreement.
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: a cross-sectional web-based survey.
BMJ Open
May 2021
Department of Pediatrics II, University Hospital Essen, Essen, Germany
Background: Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN.
Patients, Design And Setting: We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey.
Comparison of EQ-5D and 15D instruments for assessing the health-related quality of life in cardiac surgery patients.
Eur Heart J Qual Care Clin Outcomes
July 2016
School of Pharmacy, Pharmacoeconomics and Outcomes Research Unit (PHORU), University of Eastern Finland, Kuopio, Finland.
Article Synopsis
- The study compares two health-related quality-of-life (HRQoL) measures, EQ-5D and 15D, in patients undergoing elective coronary artery bypass grafting (CABG) to assess their effectiveness.
- Conducted on 182 patients at Kuopio University Hospital between 2012 and 2014, the study found that the EQ-5D had lower baseline scores and poor agreement with the 15D instrument, but was better at distinguishing patient groups.
- Results showed that while both measures indicated significant patient improvement after one year, the EQ-5D required fewer patients to demonstrate an additional quality-adjusted life year (QALY) gain compared to the 15D, suggesting they are not interchangeable.
Intravesical Bacillus Calmette-Guérin Versus Combination of Epirubicin and Interferon-α2a in Reducing Recurrence of Non-Muscle-invasive Bladder Carcinoma: FinnBladder-6 Study.
Eur Urol
August 2016
Department of Surgery, Hyvinkää Hospital and Helsinki University Hospital, Hyvinkää, Finland.
Background: Patients with non-muscle-invasive bladder cancer (NMIBC) belonging to the intermediate-risk group should be treated with intravesical instillations to prevent recurrence and progression.
Objective: We compared the outcome of a monthly maintenance bacillus Calmette-Guérin (BCG) regimen with that of epirubicin (EPI) and interferon-α2a (IFN) in patients with NMIBC.
Design, Setting, And Participants: Our prospective randomized multicenter study comprised 229 eligible patients with frequently recurrent TaT1 grade 1-2 or low-grade NMIBC enrolled between 1997 and 2008.