528 results match your criteria: "Hypothyroidism and Myxedema Coma"
When Eyes Speak Louder: Uncontrolled Hypothyroidism Revealed Through Madarosis and Eyelid Edema.
Acta Med Port
November 2024
Serviço de Endocrinologia. Unidade Local de Saúde Gaia e Espinho. Vila Nova de Gaia. Portugal.
Myxedema Coma-associated Pancytopenia: A Case Report.
Rambam Maimonides Med J
October 2024
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- Pancytopenia is a condition characterized by low levels of red and white blood cells as well as platelets, and diagnosing it can be complex due to various potential causes.
- The text discusses a rare case of a 53-year-old man experiencing myxedema coma, a severe form of untreated hypothyroidism, which led to his pancytopenia symptoms, including confusion and unstable vital signs.
- The patient was treated with intravenous levothyroxine and other supportive measures, resulting in improved health and normalized blood counts, highlighting the importance of recognizing myxedema coma in older patients who may not have regular healthcare access.
Myxedema Coma as a Presentation of Panhypopituitarism Secondary to Traumatic Brain Injury.
Case Rep Endocrinol
October 2024
Department of Endocrinology and Nutrition, Central University Hospital of Asturias/University of Oviedo, Oviedo, Spain.
Article Synopsis
- Myxedema coma often involves reduced consciousness and low body temperature, potentially linked to thyroid issues, especially in patients with head trauma and central hormone deficiencies.
- A 52-year-old man with head trauma exhibited symptoms like drowsiness and hypotension, with initial tests showing normal TSH levels but low ACTH and FT4, and his condition worsened before improving with medication.
- The case highlights the importance of assessing both TSH and FT4 levels for diagnosing central hypothyroidism, as relying solely on TSH might lead to overlooked conditions in patients showing hormone deficiency symptoms post-trauma.
Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review.
Case Rep Endocrinol
October 2024
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
- Myxedema coma is a severe and rare complication of hypothyroidism resulting in various body system failures, including neuropsychiatric and cardiovascular issues.
- From 2010 to 2022, our hospital treated three cases of myxedema coma, which showed similar characteristics to past reports, but all were negative for thyroid autoantibodies, with one case revealing end-stage thyroiditis during autopsy.
- A review of cases from 1999 to 2022 indicated that many instances of myxedema coma were linked to seronegative primary hypothyroidism, particularly notable in Japan.
Myxedema coma secondary to levothyroxine malabsorption in a patient previously submitted to bariatric surgery.
Arch Endocrinol Metab
October 2024
University of Brescia Department of Clinical and Experimental Sciences Brescia Italy Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, Azienda Socio-Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy.
Article Synopsis
- Treating hypothyroidism is complicated for patients with malabsorption, often requiring higher doses of oral levothyroxine (L-T4) due to impaired absorption.
- A case is presented of a young man with myxedema after undergoing biliopancreatic diversion surgery, showing severe hypothyroidism symptoms and requiring intravenous treatments.
- The case highlights the importance of monitoring Thyroid Stimulating Hormone (TSH) levels more frequently in post-bariatric surgery patients and suggests that liquid forms of L-T4 may be more effective than tablets in these cases.
When the Expected Becomes Unexpected: An Acute Presentation of Hypothyroidism.
JCEM Case Rep
September 2024
Department of Pediatrics, Nicklaus Children's Hospital, Miami, FL 33155, USA.
Article Synopsis
- * A case study is presented featuring a 17-year-old girl with anxiety who exhibited vague symptoms like slow heart rate caused by hypothyroidism.
- * The aim is to increase awareness about the diverse symptoms of pediatric myxedema to encourage early diagnosis and timely treatment for improved health outcomes.
More Than Under-Eye Bags: Treatment of Formidable Festoons.
Ophthalmic Plast Reconstr Surg
August 2024
Department of Ophthalmology, University of Kansas Medical Center.
Article Synopsis
- - A 64-year-old man with no medical care for 10 years was transferred to a trauma center after an unwitnessed fall, where he exhibited lethargy and significant eye swelling (festoons) along with ectropion.
- - Tests revealed he had severe hypothyroidism leading to myxedema coma, but his condition improved with treatment.
- - After surgically removing the festoons, the patient was pleased with the results, highlighting a rare case in the literature and the need to consider both appearance and function in surgical corrections.
Article Synopsis
- - Euthyroid sick syndrome (ESS) is a condition where thyroid hormone levels are abnormal despite normal thyroid function, often seen in critically ill patients, leading to low triiodothyronine levels and sometimes other hormone imbalances.
- - Myxedema coma (MC) is a serious and rare emergency resulting from severe hypothyroidism, causing multiorgan failure and may happen after significant stress or poor management of hypothyroidism, despite being infrequently linked with ESS.
- - The case study involves a 36-year-old woman who, after developing septic shock and being treated in the ICU, experienced both ESS and signs of MC, highlighting the complexities and challenges in diagnosing and managing these overlapping conditions.
Myxedema Coma: Recognition of a Rare Endocrine Emergency.
Cureus
August 2024
Intensive Care Unit, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, PRT.
Article Synopsis
- An 82-year-old patient with multiple health issues arrived at the ER showing symptoms like shortness of breath and loss of appetite, initially diagnosed with pneumonia and heart failure.
- As her health worsened with low blood pressure, slow heart rate, and low body temperature, further investigation revealed she had hypothyroidism leading to myxedema coma, a serious condition triggered by her long-term medication use and sepsis.
- Successful treatment with IV levothyroxine and glucocorticoids improved her condition, illustrating the diagnostic difficulties of myxedema coma and the need for timely recognition and treatment strategies for this rare emergency.
Case series of unusual cases of hypothyroidism-induced pericardial effusion.
J Family Med Prim Care
July 2024
Department of Internal Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, New Delhi, India.
Article Synopsis
- Hypothyroidism is a common endocrine disorder that can have a wide range of symptoms and may affect several organs in the body.
- It can be asymptomatic or severely symptomatic, and untreated cases can lead to serious complications, including cardiac issues.
- The text discusses unique case reports of patients with hypothyroidism who experienced cardiac tamponade, a life-threatening condition involving fluid accumulation around the heart.
Thyroid Disorders.
Prim Care
September 2024
Department of Family Medicine, Tidelands Health Family Medicine Residency Program, 4320 Holmestown Road, Myrtle Beach, SC 29588, USA.
Article Synopsis
- - The article provides essential information for primary care physicians on evaluating and treating various thyroid disorders, such as sick euthyroid syndrome, hyperthyroidism, hypothyroidism, and subclinical thyroid issues.
- - It emphasizes the importance of understanding these conditions to effectively manage patient care and make informed treatment decisions.
- - The review offers guidelines and key points that help physicians navigate the complexities of thyroid disorders during patient evaluations.
Article Synopsis
- Hypothermic patients in the emergency department are rare but require immediate diagnosis and treatment, as they may be in a critical condition.
- Myxedema coma, a serious complication from severe hypothyroidism, can present with symptoms like profound hypothermia, weakness, and altered mental status, sometimes even in patients with no prior thyroid issues.
- Rapid diagnosis and treatment, including thyroxine and glucocorticoid administration, led to a successful recovery in a 77-year-old female, highlighting the importance of considering myxedema coma in hypothermic patients regardless of prior medical history.
A Case Report of Myxedema Coma in the Setting of Normal Thyroid Stimulating Hormone.
Cureus
June 2024
Endocrinology, State University of New York Downstate Medical Center, New York City, USA.
Article Synopsis
- Myxedema coma (MC) is a serious and potentially lethal condition arising from severe hypothyroidism, characterized by high mortality rates.
- Diagnosis is based on clinical symptoms reflecting reduced metabolism due to insufficient active thyroid hormones.
- The case report discusses an unusual instance of MC where thyroid stimulating hormone (TSH) levels were normal and free thyroxine (FT4) was only slightly decreased.
Severe myxedema coma and pericardial effusion in a child with Down syndrome: the importance of adherence to levothyroxine therapy.
Turk J Pediatr
July 2024
Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Türkiye.
Article Synopsis
- Myxedema coma is a serious emergency caused by severe hypothyroidism, leading to symptoms like confusion, low blood pressure, and respiratory issues.
- A case study details a 2-year-old boy with Down syndrome who developed myxedema coma due to not taking his thyroid medication, resulting in cardiogenic shock and the need for mechanical ventilation.
- He was treated with oral L-thyroxine, showing significant improvement, and made a full recovery by day 15, highlighting a unique and effective treatment approach contrary to standard intravenous methods.
A Case of Myxedema Coma and Adrenal Insufficiency Post Pembrolizumab.
Case Rep Endocrinol
July 2024
Endocrinology Division Louis Pasteur Hospital, Le Coudray, France.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) like pembrolizumab have notable clinical advantages but can cause serious side effects known as immune-related adverse events (irAEs), affecting various organ systems.
- A case study of a female patient revealed that she experienced myxedema coma (MC) and adrenal insufficiency (AI) four months after stopping treatment with pembrolizumab, necessitating treatment with levothyroxine and hydrocortisone.
- This highlights the need for careful monitoring of patients on ICIs for potential endocrine disorders, as they can lead to severe health complications if not detected early.
Increased incidence of myxedema coma during the COVID-19 pandemic and in the post pandemic era: a single-center case series.
Intern Emerg Med
October 2024
Chair and Department of Endocrinology, Jagiellonian University Medical College, ul. Jakubowskiego 2, 30-688, Kraków, Poland.
Article Synopsis
- * A study at a Polish hospital found that while only 1 case of MC was recorded from 2015 to 2019, there were 10 cases reported during and after the pandemic, highlighting a concerning trend.
- * Factors contributing to the increase included worsening hypothyroidism due to non-compliance with therapy, as well as difficulties in accessing required medication, emphasizing the need for better patient communication and ongoing primary care for those with thyroid issues.
Navigating the Storm: Myxedema Coma-Induced Cardiomyopathy Culminating in Refractory Cardiogenic Shock.
Cureus
June 2024
Cardiology, Northwell Health, Manhasset, USA.
Article Synopsis
- Myxedema coma is a serious condition resulting from severe hypothyroidism, often triggered by physical stress, and can lead to significant heart issues.
- A 23-year-old male with untreated hypothyroidism developed cardiomyopathy and went into cardiogenic shock, requiring advanced treatments like VA-ECMO and eventually a heart transplant.
- The case underscores the importance of quick diagnosis and treatment to reduce the high risk of death linked to myxedema coma.
Untreated Primary Hypothyroidism Manifesting as Cardiac Tamponade.
Cureus
May 2024
Cardiology, St. Francis Hospital, Roslyn, USA.
Article Synopsis
- - Hypothyroidism leads to low thyroid hormone levels, affecting various organ systems and commonly causing heart issues like bradycardia and decreased cardiac output.
- - In severe cases, hypothyroidism can result in pericardial effusion, which may progress to cardiac tamponade; however, these patients often show milder symptoms than those with other causes of cardiac tamponade.
- - Close monitoring of patients with hypothyroidism-related pericardial effusions is crucial for early diagnosis and treatment, exemplified by a case of a 73-year-old male requiring an emergency procedure for cardiac tamponade.
Severe Post-partum Hypothyroidism Triggering Psychogenic Non-epileptiform Seizures, Myopathy, and Myxedema Coma.
Cureus
May 2024
Neurology, Bon Secours St. Francis Health System, Greenville, USA.
Article Synopsis
- - A 29-year-old woman with a history of anxiety, ADHD, and post-partum depression experienced confusion and seizure-like episodes five months after giving birth, leading to a diagnosis of severe post-partum hypothyroidism and its related complications.
- - Initial lab tests revealed extremely high TSH and low T4 levels, alongside elevated creatine kinase, indicating severe hypothyroidism and muscle damage, which were associated with her non-epileptic seizures.
- - Treatment with levothyroxine significantly improved her condition, highlighting the need for comprehensive endocrine evaluations in post-partum patients who present with neuropsychiatric symptoms.
Indications for Intravenous T3 and T4.
Horm Metab Res
August 2024
Klinikum Bielefeld, Academic Department of General Internal Medicine, Endocrinology and Diabetes, Infectiology, Bielefeld University, Medical School and University Medical Center East Westphalia-Lippe, Bielefeld, Germany.
Article Synopsis
- - Therapy with thyroid hormones is primarily for treating hypothyroidism, using oral medication most of the time, with intravenous options only for specific cases like gastrointestinal issues or severe medical conditions.
- - Levothyroxine is the preferred treatment for various conditions, including congenital hypothyroidism and myxoedema coma, where intravenous administration is used until patients can resume oral therapy.
- - Although intravenous thyroid hormones can improve cardiac function after surgery, studies show no significant impact on overall morbidity or mortality, and oral administration is equally effective in many situations.
Severe bradycardia at acute medical take - Think about myxoedema coma.
J R Coll Physicians Edinb
June 2024
Department of Endocrinology, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, UK.
Article Synopsis
- Two patients with myxoedema coma were initially misdiagnosed with severe bradycardia as a heart issue and referred to a cardiology unit.
- Upon arrival, thyroid function tests revealed the correct diagnosis of myxoedema coma.
- Despite treatment, both patients tragically died, underscoring the importance of recognizing this condition even with advanced thyroid testing available.
Supraglottic myxoedema successfully treated orally.
Endocrinol Diabetes Metab Case Rep
January 2024
Department of Family & General Medicine, Tokyo-Kita Medical Center, Japan.
Article Synopsis
- Myxoedema coma is a serious condition resulting from severe hypothyroidism, leading to multiple organ dysfunction, altered consciousness, and low body temperature, with high mortality rates if not treated early.
- A case study highlighted a 66-year-old man who presented with severe symptoms and was later diagnosed with myxoedema coma and laryngeal swelling, requiring intubation and tracheostomy to manage respiratory failure.
- Despite the challenges posed by the supraglottic swelling, the patient improved and was treated successfully with oral thyroid medication, demonstrating that this condition can sometimes be managed without invasive procedures.
Clinical Features and Outcomes of Myxedema Coma in Patients Hospitalized for Hypothyroidism: Analysis of the United States National Inpatient Sample.
Thyroid
April 2024
Division of Endocrinology and Diabetes; Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Article Synopsis
- Hypothyroidism is a prevalent endocrine disorder that can lead to serious health issues, particularly in its severe form known as myxedema coma (MC), which is life-threatening and occurs less frequently.
- This study compared clinical features and outcomes of patients with MC to those with hypothyroidism not experiencing MC, analyzing data from a large U.S. hospital database between 2016 and 2018.
- Findings showed that patients with MC had significantly higher mortality rates (6.8% vs. 0.7%), longer hospital stays (9.64 days vs. 4.62 days), and higher healthcare costs ($21,768 vs. $8,941) compared to those without MC.
Life-Threatening Cardiac Arrhythmias in a Case of Undetected Myxedema Coma: Importance of Early Detection and Medication Adherence.
Am J Case Rep
November 2023
Internal Medicine Residency Program, Camden Clark Medical Center, Parkersburg, WV, USA.
Article Synopsis
- * A 59-year-old woman was initially misdiagnosed with a stroke but later identified as having myxedema coma after multiple cardiac arrests, due to not taking her medications for weeks.
- * The case highlights the necessity of early diagnosis and treatment for myxedema coma to prevent dangerous heart problems and stresses the importance of patients adhering to their medication regimens.