949 results match your criteria: "Hyperviscosity Syndrome"
Hum Pathol
December 2024
Departments of Hematopathology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:
There has been remarkable progress over the past 80 years since Jan Waldenstrom first described patients with a hyperviscosity syndrome related to IgM paraprotein in 1944. The definition of Waldenstrom macroglobulinemia (WM) has evolved from a clinical syndrome to a distinct clinicopathologic entity with characteristic morphology, immunophenotype and molecular features. The landmark discovery of MYD88 mutation among most WM cases in 2012 marked the dawning of an era of molecular genomic exploration that led to a paradigm shift in clinical practice.
View Article and Find Full Text PDFAm J Emerg Med
November 2024
Department of Emergency Medicine, University of Ottawa, Ottawa, Canada. Electronic address:
Introduction: Multiple myeloma (MM) and its complications carry a high rate of morbidity and mortality.
Objective: This review evaluates MM and its complications, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence.
Discussion: MM is the second most common hematologic cancer and associated with monoclonal plasma cell proliferation.
Am J Dermatopathol
December 2024
Pathologist, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
Background: Microvascular thrombosis is key to the pathogenesis of calciphylaxis. C5b-9-mediated microvascular injury reflective of complement pathway activation could be a key pathophysiologic event.
Methods: We conducted a retrospective multicenter study of 24 patients who have had biopsy-supported calciphylaxis from the 2010-2022 data base from Emory where C5b-9 immunohistochemistry (IHC) had not been conducted and the 2019-2023 data base from Cornell where C5b-9 IHC was done as part of the routine calciphylaxis work up.
Front Vet Sci
November 2024
Department of Veterinary Science, University of Turin, Grugliasco, TO, Italy.
Cureus
October 2024
Rheumatology, Royal Free London NHS Foundation Trust, London, GBR.
Immunoglobulin G4 (IgG4)-related disease is a rare multi-system immune-mediated inflammatory condition. Pathologically, it is associated with an increase in plasma IgG4 levels and tissue infiltration of IgG4-secreting plasma cells of any organ. Clinical features vary, but it usually presents with the diffuse enlargement and dysfunction of the affected organ.
View Article and Find Full Text PDFPulse (Basel)
August 2024
Stroke Care, Neurology Operating Unit, Emergency-Urgency Department, University-Hospital of Parma, Parma, Italy.
Vet Med Sci
November 2024
Easter Bush Pathology, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, UK.
A 10-year-old female neutered Labrador Retriever presented with epistaxis, discoloration and crusting of the nose and a necrotic lesion on the lip. Bloodwork revealed pancytopenia, azotemia, hypoalbuminemia and hyperglobulinemia. Aggregates of amorphous basophilic material were seen in a room-temperature blood smear which were not present in the sample after warming to 37°C, and grossly a cryoprecipitate was noted in the patient's serum at 4°C.
View Article and Find Full Text PDFWaldenstrom's macroglobulinemia (WM) or lymphoplasmacytic lymphoma is a B-cell malignancy characterized by lymphoplasmacytic cells in the bone marrow that secrete high amounts of immunoglobulin (Ig) M. The large pentameric structure of IgM leads to a variety of unique complications in WM, such as hyperviscosity syndrome, cryoglobulinemia and sensory neuropathy. Furthermore, malignant cells can infiltrate the central nervous system and lead to a variety of neurological complications, also known as Bing Neel Syndrome.
View Article and Find Full Text PDFJ Community Hosp Intern Med Perspect
September 2024
Department of Hematology Oncology, SSM Health St Louis University Hospital, St. Louis, MO.
Photodiagnosis Photodyn Ther
December 2024
Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Photodiagnosis Photodyn Ther
December 2024
Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong. Electronic address:
Ann Med Surg (Lond)
October 2024
Department of Internal Medicine (Neurology), Faculty of Medicine, Damascus University, AL fayhaa Hospital, Damascus, Syrian Arab Republic.
Leuk Res Rep
August 2024
University of Miami, Department of Hematology, Miami, USA.
In the context of chronic lymphocytic leukemia (CLL), Hyperviscosity Syndrome (HVS) typically arises from hyperleukocytosis, although it infrequently stems from IgM hyperparaproteinemia. We present a distinctive case of HVS induced by IgM hyperparaproteinemia in a patient experiencing relapsed CLL, marked by bulky disease and cytopenias upon progression. The patient exhibited new symptoms, including headache, dizziness, and confusion.
View Article and Find Full Text PDFJ Hematol
August 2024
2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Cureus
August 2024
Ophthalmology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Front Med (Lausanne)
August 2024
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Rev Med Interne
December 2024
Service immuno-hématologie, hôpital Saint Louis, Paris, France; Université Paris Cité, institut de recherche Saint-Louis, Inserm U944, Paris, France. Electronic address:
Cureus
July 2024
Geriatrics, Luton and Dunstable University Hospital, Luton, GBR.
Natl Med J India
August 2024
Department of General Medicine Believers Church Medical College Hospital, Tiruvalla, Kerala, India.
Ann Intensive Care
July 2024
Service de Médecine Intensive-Réanimation, Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 184 rue du Faubourg Saint-Antoine, 75571, Paris Cedex 12, France.
Lab Med
July 2024
Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, US.
Mediterr J Hematol Infect Dis
July 2024
Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Photodiagnosis Photodyn Ther
August 2024
Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Purpose: To evaluate the retinal vessel density (VD) with optical coherence tomography angiography (OCTA) in asymptomatic patients affected by Waldenström macroglobulinemia (WM) without hyperviscosity syndrome (HVS) and to highlight the presence of microvascular damage in theese clinically asymptomatic WD patients.
Design: Prospective study.
Methods: A total of 43 eyes from 43 WM patients (24 females, 19 males, mean age 55.
CEN Case Rep
July 2024
Department of CardioRenal and CerebroVascular Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
JCEM Case Rep
June 2024
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.