11 results match your criteria: "Hyperuricosuria and Gouty Diathesis"
Metabolic diagnosis in stone formers in relation to body mass index.
Urol Res
February 2012
Instituto de Investigaciones Metabólicas, Universidad del Salvador, Libertad 836 1 piso, 1012 Buenos Aires, Argentina.
It is known that several metabolic abnormalities that favor stone formation have a strong dependence on environmental and nutritional factors. The incidence and prevalence of kidney stone is increasing while there has been a parallel growth in the overweight/obesity rate, and epidemiologic studies have shown a significant association between overweight/obesity and increased nephrolithiasis risk. The aim of this study was to assess if metabolic abnormalities observed in stone patients differ in relation to their BMI.
View Article and Find Full Text PDFMetabolic abnormalities associated with calyceal diverticular stones.
BJU Int
May 2006
Department of Urology, Naval Medical Center, San Diego, CA, USA.
Objective: To review the metabolic analyses of patients with calyceal diverticular stones who had surgical treatment of their calculi and to examine the effect of selective medical therapy on stone recurrence, as recent reports suggest that metabolic abnormalities contribute to stone development.
Patients And Methods: In all, 37 patients who had endoscopic treatment of symptomatic calyceal diverticular calculi were retrospectively reviewed. Stone composition and initial 24-h urine collections (24-h urinary volumes, pH, calcium, sodium, uric acid, oxalate, citrate, and the number of abnormalities/patient per collection) were compared with 20 randomly selected stone-forming patients (controls) with no known anatomical abnormalities.
Ethnic background has minimal impact on the etiology of nephrolithiasis.
J Urol
June 2005
Comprehensive Kidney Stone Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Purpose: Nephrolithiasis disproportionately affects white patients. However, recent studies propose an increase in the incidence of stone disease in nonwhite populations. We compared the metabolic risk factors of ethnically disparate stone formers from the same geographic region.
View Article and Find Full Text PDFMedical management of urinary stone disease.
Nephron Clin Pract
May 2006
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Tex 75390-8571, USA.
Article Synopsis
- * Metabolic issues such as high calcium (hypercalciuria), low citrate (hypocitraturia), and others can also contribute to stone formation.
- * Dietary changes, focusing on increased fluid intake and balanced diets, are important, but if ineffective, medications like thiazide or potassium citrate might be needed for treatment.
Metabolic risk factors and the impact of medical therapy on the management of nephrolithiasis in obese patients.
J Urol
July 2004
Comprehensive Kidney Stone Center, The Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
Article Synopsis
- Obesity increases the risk of stone formation and recurrence of stone disease, but medical management can effectively reduce these risks among affected individuals.
- A study analyzed 140 obese stone patients, revealing high rates of metabolic abnormalities like gout and hypocitraturia, with over half forming uric acid stones.
- Following targeted medical therapy, both obese and nonobese patients showed improved metabolic conditions and a notable drop in the rate of new stone formation from 1.75 to 0.15 stones per year.
Metabolic abnormalities associated with renal calculi in patients with horseshoe kidneys.
J Endourol
March 2004
Division of Urology, Duke University Medical Center, Durham, North Carolina.
Background And Purpose: Horseshoe kidneys are a complex anatomic variant of fused kidneys, with a 20% reported incidence of associated calculi. Anatomic causes such as high insertion of the ureter on the renal pelvis and obstruction of the ureteropelvic junction are thought to contribute to stone formation via impaired drainage, with urinary stasis, and an increased incidence of infection. In this multi-institutional study, we evaluated whether metabolic factors contributed to stone development in patients with horseshoe kidneys.
View Article and Find Full Text PDFPredictive value of kidney stone composition in the detection of metabolic abnormalities.
Am J Med
July 2003
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA.
Article Synopsis
- The study analyzed 1392 kidney stone patients to explore the relationship between kidney stone composition and underlying medical diagnoses.
- The most common stones found were calcium oxalate, with specific compositions linked to certain medical conditions like renal tubular acidosis and hyperparathyroidism.
- The findings suggest that the type of kidney stone can help predict associated medical conditions, especially for noncalcareous stones.
Pathophysiology of uric acid nephrolithiasis.
Endocrinol Metab Clin North Am
December 2002
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, Center of Human Nutrition, University of Texas Southwestern Medical Center, Department of Veteran Affairs Medical Center, Dallas, TX, USA.
Article Synopsis
- Humans can excrete nitrogen primarily through uric acid and ammonia, but imbalances can lead to uric acid build-up in urine.
- Uric acid nephrolithiasis is caused by multiple factors, including high uric acid levels, acidic urine, and low urine volume, which can stem from genetic, secondary, or unknown causes.
- A particular type of uric acid nephrolithiasis may indicate a larger health issue related to insulin resistance, which also involves a mild defect in ammonium excretion, creating conditions favorable for uric acid stone formation.
Biochemical distinction between hyperuricosuric calcium urolithiasis and gouty diathesis.
Urology
November 2002
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA.
Article Synopsis
- The study aims to compare the biochemical and urinary characteristics of patients with hyperuricosuria and calcium stones (HUCU) to those with gouty diathesis (GD) and uric acid stones.
- The results show that GD patients have higher serum uric acid levels, lower urinary uric acid, and lower urinary pH compared to HUCU patients, who also exhibit increased urinary saturation of sodium urate and calcium oxalate.
- The findings suggest that HUCU patients have different urinary profiles that contribute to their stone formation, highlighting distinct mechanisms between HUCU and GD.
[Metabolic changes in 2612 patients with nephrolithiasis].
Medicina (B Aires)
March 2000
Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina.
Article Synopsis
- An evaluation of 2,612 patients identified 15 categories of biochemical issues, with idiopathic hypercalciuria (excess calcium in urine) being the most prevalent at 31.2%.
- This study highlights the need for comprehensive biochemical assessments in kidney stone patients to diagnose underlying metabolic abnormalities and prevent future stone formation.
Ambulatory evaluation of nephrolithiasis: an update of a 1980 protocol.
Am J Med
January 1995
Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Evaluations of 1,270 patients with recurrent nephrolithiasis in an outpatient setting were analyzed for the purpose of updating the classification of nephrolithiasis. All but 4% had abnormal urinary biochemistry that placed them into one or more of 20 etiologic categories. A single diagnosis was documented in 41.
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