5,664 results match your criteria: "Hyperaldosteronism Primary"
Synergistic interplay between cortisol and aldosterone: unveiling mechanisms of vascular calcification in hyperaldosteronism.
Hypertens Res
December 2024
Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan.
The synergistic interplay between cortisol and aldosterone is critical for maintaining homeostasis, particularly in blood pressure regulation, fluid balance, and stress response. Cortisol, a glucocorticoid, and aldosterone, a mineralocorticoid, often act in tandem to regulate sodium retention and blood volume. Dysregulation of these hormones, as seen in hyperaldosteronism or Cushing's syndrome, contributes to hypertension and metabolic imbalances.
View Article and Find Full Text PDFUsing Point of Care Rapid Cortisol Measurement During Adrenal Venous Sampling in Primary Hyperaldosteronism.
Diagnostics (Basel)
November 2024
Endocrinology Unit, Bnai Zion Medical Center, 47 Eliyahu Golomb Boulevard, Haifa 31048, Israel.
: To assess success rates and cost-effectiveness of adrenal venous sampling (AVS) after implementing point-of-care rapid cortisol (RC) testing conducted using a europium nanoparticle-based fluoro-immunoassay in patients with primary hyperaldosteronism. : A retrospective review of AVS procedures was conducted at our medical center between January 2016 and June 2024. The primary objective was to compare the success rates of AVS before and after the implementation of the RC testing.
View Article and Find Full Text PDFDiagnosis of Primary Aldosteronism without Discontinuation of Interfering Antihypertensive Medications.
Curr Hypertens Rep
December 2024
Department of Endocrinology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No.88, Jiefang Road, Shangcheng District, Hangzhou, 310000, China.
Purpose Of Review: One of the challenges in the diagnosis and management of primary aldosteronism (PA), the most common type of secondary hypertension with curative potential, is the modification of antihypertensive medications. We seek to explore whether these medications can be continued during the diagnostic process of PA to minimize the duration and risks associated with medication adjustments.
Recent Findings: We searched PubMed for eligible original literature between 1990 and 2024 using the following keywords: (screening) AND (primary aldosteronism); (confirmatory) AND (primary aldosteronism); (adrenal vein sampling) AND primary aldosteronism).
Impact of confirmatory test results on subtype classification and biochemical outcome following unilateral adrenalectomy in patients with primary aldosteronism.
Front Endocrinol (Lausanne)
December 2024
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.
Context: Primary aldosteronism (PA) is the most common form of endocrine hypertension. According to the Endocrine Society Practice Guidelines, the diagnosis of PA requires a pathological screening test result and non-suppressible aldosterone levels during confirmatory testing. Sequential testing with more than one confirmatory test may result in discordant test results.
View Article and Find Full Text PDF[F]AlF-NOTA-pentixather PET/CT of CXCR4 in patients with suspected primary hyperaldosteronism.
Theranostics
December 2024
Department of Nuclear Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Distinguishing unilateral aldosterone-producing adenomas (APA) from idiopathic hyperaldosteronism (IHA), nonfunctional adrenal adenoma (NFA), and pheochromocytoma (PHEO) within primary aldosteronism (PA) presents a significant challenge. Studies have demonstrated high levels of chemokine receptor (CXCR) 4 expression in APA, thereby validating the use of Ga-labeled CXCR4 PET/CT for detecting APA. This study evaluates the efficacy of [F]AlF-NOTA-pentixather PET/CT in distinguishing APA from other PA types.
View Article and Find Full Text PDF[Value of 24-hour urinary aldosterone in diagnosis and classification of primary hyperaldosteronism].
Zhonghua Yi Xue Za Zhi
December 2024
Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha410013, China.
Article Synopsis
- The study aimed to evaluate the effectiveness of 24-hour urinary aldosterone (UEA) for diagnosing and classifying primary aldosteronism (PA) among 282 hypertensive patients admitted to a university hospital between December 2020 and December 2023.
- After excluding patients with secondary hypertension, 243 subjects were analyzed, revealing a distinction between PA (135 patients) and primary hypertension (108 patients) based on the causes of their hypertension.
- Findings showed that specific measurements like serum potassium and plasma renin activity were significantly lower in the PA group compared to the primary hypertension group, indicating potential biomarkers for PA diagnosis and classification.
Diagnosis and Management of Adrenocortical Carcinoma with Co-secretion of Cortisol and Aldosterone: A Case Report.
J ASEAN Fed Endocr Soc
December 2024
Department of Internal Medicine, Chong Hua Hospital, Cebu City, Philippines.
Article Synopsis
- * A 44-year-old Filipino woman showed symptoms like abdominal weight gain and fatigue due to excess hormones from a 12-year-old left adrenal incidentaloma, leading to a diagnosis of Cushing's syndrome and primary hyperaldosteronism following lab tests.
- * The patient underwent successful surgery to remove the adrenal mass, which was confirmed to be ACC, and received radiotherapy post-operation; the case highlights the importance of evaluating adrenal masses for potential malignancy.
ATP2A3 in Primary Aldosteronism: Machine Learning-Based Discovery and Functional Validation.
Hypertension
December 2024
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany (Z.S., Y.P., M.B., M.R., T.A.W.).
Article Synopsis
Glucocorticoids and mineralocorticoids in hair: facilitating accurate diagnosis of adrenal-related endocrine disorders.
Front Endocrinol (Lausanne)
November 2024
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.
Article Synopsis
- A study was conducted to investigate the presence of mineralocorticoids and glucocorticoids, particularly focusing on aldosterone and 18-hydroxycorticosterone, in hair follicles, which has not been reported before.
- Hair samples from 15 healthy volunteers were analyzed using advanced extraction and mass spectrometry techniques, allowing for the detection of various steroids without significant differences between genders.
- Notable findings included the detection of deoxycortisol, deoxycorticosterone, and 18-hydroxycorticosterone for the first time in hair, showing variability in levels for some steroids but stability in others across individuals.
Larger size of Conn's adenoma is associated with lower cure rates post adrenalectomy.
Langenbecks Arch Surg
November 2024
Division of Endocrine Surgery, National University Hospital, Singapore, Singapore.
Article Synopsis
Clinical and Metabolic Characteristics and Follow-Up Results of Adrenal Incidentalomas: A 10-Year Experience.
Cureus
October 2024
Internal Medicine, Birmingham Heartlands Hospital, Birmingham, GBR.
Objective: In this retrospective study, we aimed to investigate the clinical, hormonal, and radiological characteristics of patients with adrenal incidentalomas (AIs), to assess the prevalence of metabolic syndrome components in patients with AIs, and to determine whether changes in tumor size or hormonal activity occur during long-term follow-up in patients with AIs.
Methods: We retrospectively analyzed data from 384 patients diagnosed with AI between 2010 and 2020. Data regarding radiological, hormonal, and metabolic investigations in diagnosis and also during follow-ups were collected.
GAPPA: Enhancing prognosis prediction in primary aldosteronism post-adrenalectomy using graph-based modeling.
Artif Intell Med
January 2025
Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan. Electronic address:
Background And Objective: Predicting postoperative prognosis is vital for clinical decision making in patients undergoing adrenalectomy (ADX). This study introduced GAPPA, a novel GNN-based approach, to predict post-ADX outcomes in patients with unilateral primary aldosteronism (UPA). The objective was to leverage the intricate dependencies between clinico-biochemical features and clinical outcomes using GNNs integrated into a bipartite graph structure to enhance prognostic prediction accuracy.
View Article and Find Full Text PDFChronological outcomes of renal function after adrenalectomy in patients with primary aldosteronism across age groups.
Front Endocrinol (Lausanne)
November 2024
Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai, China.
Article Synopsis
Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism: a cohort study.
Eur J Endocrinol
November 2024
Endocrinology & Nutrition Department, Hospital Clinic, University of Barcelona, IDIPAS, Barcelona 08036, Spain.
Article Synopsis
- The study aimed to assess the impact of smoking on the health profile and surgical outcomes of patients with primary aldosteronism (PA).
- In a retrospective analysis of 881 PA patients from 36 Spanish hospitals, smokers exhibited higher rates of left ventricular hypertrophy (LVH) and larger adrenal tumors compared to non-smokers, although their blood pressure and potassium levels were similar at diagnosis.
- The results indicated that while smoking is linked to a greater prevalence of LVH and mild autonomous cortisol secretion (MACS), it does not significantly influence hypertension cure rates after surgery for PA.
Targeted multiplex proteomics for the development and validation of biomarkers in primary aldosteronism subtyping.
Eur J Endocrinol
November 2024
Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Article Synopsis
Aldosterone in the brain and cognition: knowns and unknowns.
Front Endocrinol (Lausanne)
November 2024
Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland.
Article Synopsis
- Mineralocorticoid receptors are found in various parts of the brain, and although aldosterone levels in the brain are lower than in the bloodstream, they can still lead to significant clinical effects.
- High aldosterone levels, seen in conditions like primary aldosteronism, are linked to secondary hypertension and can negatively affect cerebral functions, contributing to anxiety and depression, which are tied to cognitive impairments.
- The mini review highlights the known effects of aldosterone on brain health while addressing the uncertainties surrounding its influence on cognitive functions independent of blood pressure.
Role of unilateral-cannulating adrenal venous sampling for the subtyping of primary aldosteronism for adrenalectomy: Experience from a low-volume center.
World J Surg
December 2024
Department of Surgery, Alice Ho Miu Ling Nethersole Hospital, Hospital Authority, Hong Kong, China.
Article Synopsis
- Current guidelines recommend adrenal venous sampling (AVS) for determining the subtype of primary aldosteronism (PA), but success rates can be low at smaller medical centers, especially for bilateral cannulation.
- In a study involving 50 patients from 2009 to 2023, 66% underwent successful unilateral adrenalectomy, with specific indices developed to assess unilateral PA (uPA) effectively through unilateral-cannulating AVS.
- The study found that using a lateralization index and modified thresholds for the contralateral suppression index (CSI) and relative aldosterone secretion index (RASI) could accurately identify patients for unilateral adrenalectomy, achieving a higher positive predictive value than traditional imaging methods.
Soluble αKlotho concentration in the inferior vena cava of patients with primary aldosteronism.
Nefrologia (Engl Ed)
November 2024
Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan.
Article Synopsis
- - The study investigates the levels of soluble αKlotho, a protein linked to aging, found in blood, particularly focusing on its origin from the kidneys.
- - Blood samples were taken from patients during adrenal venous catheterization to measure αKlotho levels in different sections of the inferior vena cava.
- - Results showed higher αKlotho concentrations above the kidneys (suprarenal) compared to below (infrarenal), indicating that the kidneys significantly contribute to αKlotho levels in the bloodstream.
Comparative Analysis of Liquid Chromatography-Tandem Mass Spectrometry and Radioimmunoassay in Determining Plasma Aldosterone Concentration and Plasma Renin Activity for Primary Aldosteronism Screening.
Endocrinol Metab (Seoul)
November 2024
Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Article Synopsis
Beyond pharmacotherapy: bilateral adrenal artery embolization as a potential game-changer for idiopathic hyperaldosteronism patients.
Hypertens Res
November 2024
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Common incidental urological lesions on computed tomography images: What to do with renal and adrenal computed tomography incidentalomas in a primary care setting.
Aust J Gen Pract
November 2024
MBBS, PhD, FRACS (Urol), Professor, Department of Surgery, The University of Melbourne, Melbourne, Vic; Founding Director, EJ Whitten Prostate Cancer Research Centre at Epworth Healthcare, Melbourne, Vic;@Head of Unit, Department of Urology, The Royal Melbourne Hospital, Melbourne, Vic.
Article Synopsis
- The increased use of imaging techniques has led to more frequent detection of incidental findings in the kidneys and adrenal glands, often referred to as incidentalomas, which are commonly encountered by general practitioners.* -
- This review provides guidelines for managing these renal and adrenal masses, highlighting that renal lesions are seen in about 14% of CT scans and should be assessed using the Bosniak classification for cystic lesions.* -
- For renal cell carcinomas larger than 4 cm or showing symptoms, active treatment is recommended, while adrenal lesions require functional testing, with specific screening tests indicated based on clinical signs such as hypertension.*
Autonomous cortisol secretion promotes vascular calcification in vivo and in vitro under hyperaldosteronism.
Hypertens Res
November 2024
Department of Business Administration and Graduate School of Service Management, Chihlee University of Technology, New Taipei City, Taiwan, ROC.
Article Synopsis
- Autonomous cortisol secretion (ACS) is often found in primary aldosteronism (PA) patients, but its impact on cardiovascular health, particularly vascular calcification, is not well understood.
- In a study of 339 PA patients, those with ACS had significantly higher abdominal aortic calcification (AAC) scores compared to those without ACS, indicating a stronger cardiovascular burden.
- The research also shows that cortisol enhances vascular calcification in the presence of high aldosterone levels through a mineralocorticoid receptor mechanism, which can be blocked by the drug eplerenone.
Evolutionary Characteristics in Primary Aldosteronism Patients.
Hypertension
January 2025
National Health Commission Key Laboratory of Endocrinology, Department of Endocrinology (Y.G., Y.W., Y. Zhou, M.N., A.T.), Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Article Synopsis
Article Synopsis
- Primary aldosteronism is a condition marked by excessive aldosterone production due to adrenal gland lesions, primarily characterized by disrupted regulation of aldosterone synthase (CYP11B2).
- In a study of aldosterone-producing adenomas (APAs) without known mutations, researchers discovered specific mutations in the gene for mucolipin-3 (TRPML3) associated with increased calcium activity and aldosterone production.
- These findings suggest that mutations in TRPML3 may contribute to hormone excess in primary aldosteronism, highlighting the disease's underlying genetic factors and their impact on hypertension.
Prognostic Predictors of Hypertension Outcomes After Adrenalectomy in Primary Aldosteronism.
In Vivo
October 2024
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Article Synopsis
- The study investigates why some patients still have hypertension after undergoing adrenalectomy for primary aldosteronism and aims to identify factors influencing their prognosis.
- It analyzed data from 71 patients treated between 2008 and 2022, focusing on various factors like BMI, hypertension duration, and metabolic syndrome-related diseases.
- Key findings suggest that longer duration of hypertension, the presence of metabolic syndrome-related diseases, and higher doses of antihypertensive medications are predictors of persistent hypertension after surgery.