Maternal and neonatal outcomes in pregnant women undergoing cardiac surgery: a systematic review and meta-analysis.

Objective: Cardiac diseases that require surgical intervention present a unique challenge during pregnancy and may affect both maternal and neonatal outcomes. This systematic review and meta-analysis aimed to evaluate maternal and neonatal outcomes in pregnant females undergoing cardiac surgery.

Methods: A comprehensive manual and electronic search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Sciences databases for studies published up to 31 May 2024.

Genetic susceptibility and potential therapeutic targets of unruptured intracranial aneurysms: A genome-wide study based on Mendelian randomization.

Background: At present, although some studies have offered certain insights into the genetic factors related to unruptured intracranial aneurysms (uIAs), the potential genetic targets associated with uIAs remain largely unknown. Thus, this research adopted Mendelian randomization (MR) analysis to study two genome-wide association studies on uIAs, aiming to determine the reliable genetic susceptibility and potential therapeutic targets for uIAs.

Methods: This study summarizes the data of expression quantitative trait loci (eQTL) as exposure data.

Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field.

Due to their exceptional cell compatibility, biodegradability, and capacity to trigger tissue regeneration, extracellular matrix (ECM) materials have drawn considerable attention in tissue healing and regenerative medicine. Interestingly, these materials undergo continuous degradation and release antimicrobial peptides (AMPs) while simultaneously promoting tissue regeneration, thereby exerting a potent antibacterial effect. On this basis, a variety of basic properties of ECM materials, such as porous adsorption, hydrophilic adsorption, group crosslinking, and electrostatic crosslinking, can be used to facilitate the integration of ECM materials and antibacterial agents through physical and chemical approaches in order to enhance the antibacterial efficacy.

Effects of allylestrenol on hormone levels and delivery outcomes in threatened abortion.

Objective: To investigate the effects of allylestrenol on sex hormone levels and delivery outcomes in women with threatened abortion.

Methods: This retrospective analysis examined clinical data of patients with threatened abortion treated at Huzhou Maternity & Child Health Care Hospital from January 1, 2021, to December 31, 2022. A total of 149 eligible patients were screened and divided into two groups: a control group (n=75) treated with progesterone capsules from January to December 2021, and an observation group (n=74) treated with allylestrenol from January to December 2022.

Experiences of healthcare professionals returning to work post breast cancer diagnosis in China: A descriptive qualitative study.

Breast cancer survivors face employment challenges. How to promote BC's return to work is important for improving their quality of life and promoting recovery. Numerous studies have reported that BC survivors encounter employment challenges due to cognitive limitations, alongside factors.

The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.

Skin, as the first line of defence of the human body, is exposed to dangers such as overheating substances, ultraviolet rays, and environmental pollutants, and the incidence of skin diseases is increasing annually. Oxidative stress plays a dominant role in most skin diseases. Abelmoschus manihot (L.

Association of dietary live microbe intake with all-cause and cardiovascular mortality in an older population: Evidence from NHANES 2003-2018.

Background: The relationship between dietary live microbe intake, non-dietary prebiotics/probiotics, and mortality in older adults remains unclear.

Methods: Participants from the National Health and Nutrition Examination Survey 2003-2018 were included. Participants were categorized into three groups based on estimated live microbe intake: low, medium, and high.

Prognostic and clinicopathological value of C-reactive protein in patients with bladder cancer: a meta-analysis.

Background: The prognostic value of C-reactive protein (CRP) in patients with bladder cancer (BCa) has been widely analysed; however, the results remain conflicting. Therefore, we performed this meta-analysis to identify the precise role of CRP level in predicting BCa prognosis.

Methods: PubMed, Web of Science, Embase and Cochrane Library databases were comprehensively searched until 19 April 2024.

Further confirmation of a highly prognostic grading scheme based upon tumour budding and cell cluster size in cervical squamous cell carcinoma.

Aims: Our study aimed to further confirm the clinical significance of the tumour budding activity and cell nest size-based (TBNS) grading scheme in cervical squamous cell carcinomas (SCC).

Methods And Results: We applied the TBNS system to assess the prognostic value in an institutional cohort of well-annotated cervical SCC consisting of 312 consecutive cases with surgical resection, no neoadjuvant chemotherapy and higher than stage pT1a. We found that high budding activity, single cell and TBNS grade 3 were more frequently associated with a decreased overall survival (OS) time and disease-free survival (DFS) time (P < 0.

Haemoglobin for Fall Risk Screening in Gynaecological and Obstetric Wards: Retrospective Survey and Delphi Validation.

Aims: The objective of this study is to ascertain the suitability of haemoglobin as a screening factor for falls among obstetrics and gynaecology inpatients and to formulate a stratified scheme for assessing fall risk based on haemoglobin.

Design: A retrospective analysis and Delphi surveys were employed for this investigation.

Methods: Initially, a retrospective survey analysed falls among obstetrics and gynaecology inpatients in two hospitals from January 1, 2020, to July 10, 2022.

Interleukin-22 promotes endometrial carcinoma cell proliferation and cycle progression via ERK1/2 and p38 activation.

Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors, but its underlying pathogenic mechanisms are largely obscure. Interleukin-22 (IL-22), one cytokine in the tumor immune microenvironment, was reported to be associated with carcinoma progression. Here, we aimed to investigate the regulation of IL-22 in endometrial carcinoma.

Capecitabine regulates proliferation and apoptosis of ovarian cancer SKOV3 cells via the miR-29b-3p/MMP16 molecular axis.

Objective: To investigate the molecular mechanism by which capecitabine regulates the proliferation and apoptosis of ovarian cancer SKOV3 cells through the miR-29b-3p/MMP16 axis.

Methods: SKOV3 ovarian cancer cells were treated with capecitabine, miR-29b-3p mimics, miR-29b-3p inhibitor, and MMP16 siRNA. Cell proliferation was measured using the CCK-8 assay, and apoptosis was assessed by flow cytometry.

Protective role of Yougui Yin in experimental knee osteoarthritis: From the perspective of macrophage polarization.

Knee osteoarthritis (KOA) refers to a prevalent musculoskeletal disorder, frequently complicated by substantial pain and physical disability. Yougui Yin (YGY) is a classic Chinese herbal mixture which has demonstrated potential in treating KOA. Considering that, its cryptic mechanism warrants to be deciphered, which is the subject of our present research.

Meta-analysis of electrical stimulation promoting recovery of gastrointestinal function after gynecological abdominal surgery.

Background: The effects of electrical stimulation on gastrointestinal function recovery after gynecological abdominal surgery was not clear.

Aim: To systematically evaluate the effects of electrical stimulation on gastrointestinal function recovery after gynecological abdominal surgery.

Methods: The Cochrane Library, Web of Science, PubMed, ProQuest, and the Chinese biomedical literature databases Wanfang, Weipu, and CNKI were used to search for relevant studies on controlled trials of electrical stimulation in gynecological abdominal surgery patients from self-established databases to May 2024.

Associations Between Heavy Metal Exposure from Milk and Steroid Hormones in Mothers.

Environmental exposure to heavy metals is ubiquitous. However, its relationship with steroid hormone levels is not well understood, particularly in pregnant women. This study investigated the association between prenatal heavy metal exposure and steroid hormone levels in an e-waste disposal area in China.

Collagen Hydrogel Loaded With 9-cisRA-Lip Is an Option for Treatment of Secondary Lymphedema after Surgery.

Secondary upper limb lymphedema is easy to occur after breast cancer surgery, for which treatment is limited. 9-cis-retinoic acid (9-cisRA) has been demonstrated to increase lymphangiogenesis without enhancing tumor metastasis but has the disadvantages of poor water solubility, easy decomposition in light, unstable to heat, and short half-life. Based on this, 9-cisRA-Lip with a particle size of roughly 143 nm and high dispersibility was prepared by thin-film dispersion method and verified by Malvern Laser Particle Size Analyzer and electron microscopy.

Impact of Body Mass Index on Outcomes of Cervical Cerclage: A Systematic Review and Meta-Analysis.

Introduction: The purpose of the review was to examine the impact of maternal body mass index (BMI) on outcomes of cervical cerclage for cervical insufficiency.

Methods: This prospectively registered review (CRD42024512436) searched PubMed, Embase, Scopus, and Web of Science for comparative studies published before 6 March 2024. Maternal and neonatal outcomes of females undergoing cerclage were compared based on BMI.

A Hybrid Deep Learning Model for Enhanced Structural Damage Detection: Integrating ResNet50, GoogLeNet, and Attention Mechanisms.

Quick and accurate structural damage detection is essential for maintaining the safety and integrity of infrastructure, especially following natural disasters. Traditional methods of damage assessment, which rely on manual inspections, can be labor-intensive and subject to human error. This paper introduces a hybrid deep learning model that combines the capabilities of ResNet50 and GoogLeNet, further enhanced by a convolutional block attention module (CBAM), proposed to improve both the accuracy and performance in detecting structural damage.

(TTTCA)exp Drives the Genotype-Phenotype Correlation and Genetic Anticipation in FCMTE1.

Background: The pentanucleotide (TTTCA) repeat expansion (exp) insertion, along with the accompanying (TTTTA)exp, causes familial cortical myoclonic tremor with epilepsy (FCMTE). The genotype-phenotype correlations and intergenerational instabilities related to (TTTCA)exp and (TTTTA)exp are still unclear.

Objective: The aim was to investigate the genotype-phenotype correlations and intergenerational instabilities related to (TTTCA)exp and (TTTTA)exp in FCMTE1.

Data-independent acquisition-based blood proteomics unveils predictive biomarkers for neonatal necrotizing enterocolitis.

Necrotizing enterocolitis (NEC) is a life-threatening condition affecting preterm infants, sometimes necessitating surgical treatment. This study aimed to analyze differentially expressed proteins (DEPs) and access their biological and clinical significance in the plasma of neonates with NEC. Peripheral blood samples were collected from NEC infants at various time points, and plasma was separated.

Longitudinal change in cervical length measured after prophylactic cerclage in predicting spontaneous preterm birth.

Objective: To evaluate the value of serial post-cerclage cervical length measurements in predicting preterm birth.

Methods: This was a retrospective study of women with a singleton pregnancy who underwent prophylactic transvaginal cerclage from 2017 to 2023. Prophylactic cerclage was performed in women with an obstetric history of cervical insufficiency.

Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis.

Miscarriage is a common adverse pregnancy outcome with physical and emotional effects. Identifying predictive miscarriage biomarkers should improve early detection and management. Serum kisspeptin, known for its critical role in reproductive biology, has emerged as a potential biomarker for miscarriage.