[Mechanism of n-butanol fraction of Wenxia Formula combining with gefitinib in treating non-small cell lung cancer based on network pharmacology and in vitro experiment].

This study combined network pharmacology, molecular docking, and in vitro experiments to explore the potential mechanism of the active components of the n-butanol fraction of Wenxia Formula(NWXF) combined with gefitinib(GEF) in treating non-small cell lung cancer(NSCLC). Ultra-performance liquid chromatography-quadrupole Orbitrap mass spectrometry(UPLC-Q-Orbitrap MS) was employed to detect the main chemical components of NWXF. The active components of NWXF were retrieved from SwissADME, and the candidate targets of these active components were retrieved from SwissTargetPrediction.

Effect of implantable cardioverter defibrillator on primary prevention of sudden cardiac death in high-risk patients.

Objective: To investigate the effect of implantable cardioverter defibrillator (ICD) on primary prevention of sudden cardiac death (SCD) in patients with high risk.

Methods: This retrospective analysis included 70 patients who received primary prevention of SCD by ICD implantation in Huzhou Central Hospital from March 2016 to May 2019. Based on survival, 15 patients who died during follow-up were placed into the death group and the 55 patients who survived were set as the survival group.

[The influence of zoledronic acid on proliferation, migration and apoptosis of fibroblasts].

Purpose: Bisphosphonates are commonly used to treat bone-derived malignant tumors currently. In recent years, with the widespread use of these drugs, reports on the difficulty of wound healing (DWH) increase remarkably. However, the mechanism is still unclear.

Erratum: COUP-TFII promotes colorectal carcinoma resistance to doxorubicin involving inhibition of epithelial-mesenchymal transition.

[This corrects the article on p. 3921 in vol. 8, PMID: 27725871.

[Curative effects of partial caries removal in permanent molars with deep dental caries].

Purpose: To evaluate the clinical efficacy of incomplete caries removal in permanent molars with deep dental caries.

Methods: One hundred and two permanent molars with deep dental caries were treated with partial caries removal combined with tight resin restoration. The patients were followed up for more than 6 months, the pulp retention rate and subjective feelings were evaluated.

[Experimental study of double-root implantation with the aid of template in rabbits].

Purpose: To evaluate the feasibility of double-root implantation with the aid of template.

Methods: Implant templates were fabricated based on CT data from the tibia of 12 rabbits. 12 double-root implants were placed in the tibia of rabbits under the guidance of implant templates, and single-root implants were placed in contralateral tibia of the same rabbits.

COUP-TFII promotes colorectal carcinoma resistance to doxorubicin involving inhibition of epithelial-mesenchymal transition [corrected].

Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) promotes progression of a variety of tumors. The study was designed to explore the role of COUP-TFII in colorectal carcinoma (CRC) resistance to doxorubicin. The sensitivity of CRC cell lines to doxorubicin was calculated by different proliferation rate measured with cell count kit-8 and EdU (5-Ethynyl-2'-deoxyuridine) assay.

Inhibitory effect of midkine-binding peptide on tumor proliferation and migration.

Background: To investigate the inhibitory effect of midkine-binding peptides on human umbilical vein endothelial cells (HUVECs) proliferation and angiogenesis of xenograft tumor.

Methods: The midkine-binding peptides were panned by Ph.D.

[IgG4-associated parotitis:case report and review of the literature].

A case of immunoglobulin G4 (IgG4)-associated parotitis was reported and related literatures were reviewed,in order to improve the recognization of this systemic diseases and reduce the misdiagnosis and mistreatment in clinical practice for the stomatologists.