Contrast sensitivity deficits in schizophrenia: A psychophysical investigation.

Individuals with schizophrenia have problems with visual contrast processing. The current study investigated contrast sensitivity (CS) in schizophrenia/schizoaffective disorder to elucidate the underlying neural mechanisms affected by this disorder and to identify critical testing conditions that distinguish individuals with the disorder from healthy individuals. Principal component analysis was applied to the data (N = 143) to separate responses from distinct visual pathways.

Healthy Choices Intervention is Associated with Reductions in Stigma Among Youth Living with HIV in the United States (ATN 129).

Considering the lack of validated stigma reduction interventions for youth living with HIV (YLWH), we evaluated effects of the Healthy Choices intervention on HIV-related stigma among YLWH. We analyzed data from the Adolescent Medicine Trials Network protocol 129, multi-site randomized controlled trial, applying latent growth curve modeling with two linear slopes estimating changes in Berger's Stigma Scale pre-intervention, 16, 28, and 52 weeks post-intervention, as well as the trajectory of stigma scores over the follow-up period (N = 183). Expected value for the growth intercept was statistically significant (B = 2.

Treatment Is More Than Prevention: Perceived Personal and Social Benefits of Messaging Among Sexual Minority Men Living with HIV.

Research suggests that the science of undetectable viral load (VL) status and HIV transmission-conveyed with the slogan "" or "U = U"-has gaps in acceptance despite robust scientific evidence. Nonetheless, growing acceptance of U = U creates conditions for a shift in the sociopolitical and personal implications of viral suppression. We conducted an online survey over a 23-month period in 2018 and 2019 among 30,361 adolescent and adult (aged 13-99) sexual minority men living with HIV (SMM-LHIV) across the United States.

Integrating intra-individual and dyadic factors in examining health among gay and bisexual men: A narrative review of recent literature.

Gay and bisexual men (GBM) experience disproportionate rates of mental health and other negative health outcomes. For GBM in relationships, contextualizing the myriad of negative outcomes as a dyadic process may provide insight into the mechanisms through which these adverse outcomes develop. The objective of this review is to examine the current state of the relationship science literature using a health framework, .

Colorectal Cancer-Related Knowledge, Acculturation, and Healthy Lifestyle Behaviors Among Low-Income Vietnamese Americans in the Greater Philadelphia Metropolitan Area.

Colorectal cancer (CRC) is the second and fourth most common cancer in Vietnamese American women and men, respectively. Recent research has highlighted the importance of modifiable lifestyle behaviors such as smoking, alcohol use, dietary behaviors, and physical activities in CRC prevention for the general population. However, it is not well understood how well Vietnamese Americans knew about CRC prevention and risk factors, and whether there were any disparities in knowledge within this vulnerable population.

Topology of the U12-U6 snRNA Complex of the Minor Spliceosome and Binding by NTC-Related Protein RBM22.

Splicing of precursor messenger RNA is catalyzed by the spliceosome, a dynamic ribonucleoprotein assembly including five small nuclear (sn)RNAs and >100 proteins. RNA components catalyze the two transesterification reactions, but proteins perform critical roles in assembly and rearrangement. The catalytic core comprises a paired complex of U2 and U6 snRNAs for the major form of the spliceosome and U12 and U6 snRNAs for the minor variant (∼0.

Leveraging synthetic chlorins for bio-imaging applications.

Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET).

Developmental Barriers to Couples' HIV Testing and Counseling Among Adolescent Sexual Minority Males: A Dyadic Socio-ecological Perspective.

Couples HIV Testing and Counseling (CHTC) is now a standard of care for partnered sexual minority men. While adolescent sexual minority men (ASMM; ages 15-19) face disproportionate HIV risk, the emergent nature of relationships and communication skills may present challenges to accessing and engaging in CHTC. This study utilized qualitative data from 28 ASMM recruited in 4 urban centers in the USA during the formative stage of Adolescent Trials Network study ATN-156.

New Middle Miocene Ape (Primates: Hylobatidae) from Ramnagar, India fills major gaps in the hominoid fossil record.

The fossil record of 'lesser apes' (i.e. hylobatids = gibbons and siamangs) is virtually non-existent before the latest Miocene of East Asia.

Feces are Effective Biological Samples for Measuring Pesticides and Flame Retardants in Primates.

The habitats of wild primates are increasingly threatened by surrounding anthropogenic pressures, but little is known about primate exposure to frequently used chemicals. We applied a novel method to simultaneously measure 21 legacy pesticides (OCPs), 29 current use pesticides (CUPs), 47 halogenated flame retardants (HFRs), and 19 organophosphate flame retardants in feces from baboons in the U.S.

Evaluating the impact of COVID-19: A cohort comparison study of drug use and risky sexual behavior among sexual minority men in the U.S.A.

Background: Sexual minority men who use drugs have high sexual HIV transmission risk. Sexual interactions may also increase COVID-19 risk.This study compared marijuana use, other illegal drugs use (i.

Unusual features of nitrogen substitutions in silicene.

The quasiparticle properties resulting from charge and spin are clearly identified in nitrogen-substituted silicenes, for which a theoretical framework is successfully developed from first-principles calculations. Such systems create extremely non-uniform chemical and physical environments through the distribution of the guest atoms. They present unusual geometric, electronic, and magnetic properties, which can be identified from the optimal honeycomb lattices, the atom- and spin-dominated energy spectra, the spatial charge density distributions, and the atom-, orbital- and spin-projected van Hove singularities [the net magnetic moments].

INFLUENCE OF FRUIT AVAILABILITY ON MACRONUTRIENT AND ENERGY INTAKE BY FEMALE CHIMPANZEES.

Daily energy intake of adult female mammals is influenced by environmental conditions and physiological requirements, including reproduction. We examined the effects of fruit availability on macronutrient and metabolisable energy intake by adult female chimpanzees () of the Kanyawara community in Kibale National Park, Uganda from January 2014 through June 2015. Drupe fruits were abundant for four months, whereas the other fourteen months were dominated by fig fruits.

Oxytocin receptor genetic alterations in hepatocellular carcinoma.

Purpose: Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related deaths with a very poor prognosis. Consequently, there is an urgent need for better understanding the molecular mechanisms, novel prognostic biomarkers, and more effective treatment options. There is an emerging link between oxytocin (OXT), the oxytocin receptor (OXTR), and cancer.

Genetic population structure of endangered ring-tailed lemurs () from nine sites in southern Madagascar.

Madagascar's ring-tailed lemurs () are experiencing rapid population declines due to ongoing habitat loss and fragmentation, as well as increasing exploitation for bushmeat and the illegal pet trade. Despite being the focus of extensive and ongoing behavioral studies, there is comparatively little known about the genetic population structuring of the species. Here, we present the most comprehensive population genetic analysis of ring-tailed lemurs to date from across their likely remaining geographic range.

Li-Ion Diffusion in Nanoconfined LiBH-LiI/AlO: From 2D Bulk Transport to 3D Long-Range Interfacial Dynamics.

Solid electrolytes based on LiBH receive much attention because of their high ionic conductivity, electrochemical robustness, and low interfacial resistance against Li metal. The highly conductive hexagonal modification of LiBH can be stabilized via the incorporation of LiI. If the resulting LiBH-LiI is confined to the nanopores of an oxide, such as AlO, interface-engineered LiBH-LiI/AlO is obtained that revealed promising properties as a solid electrolyte.

Evaluation of a Stepped-Care eHealth HIV Prevention Program for Diverse Adolescent Men Who Have Sex With Men: Protocol for a Hybrid Type 1 Effectiveness Implementation Trial of SMART.

Background: Adolescent men who have sex with men (AMSM), aged 13 to 18 years, account for more than 80% of teen HIV occurrences. Despite this disproportionate burden, there is a conspicuous lack of evidence-based HIV prevention programs. Implementation issues are critical as traditional HIV prevention delivery channels (eg, community-based organizations, schools) have significant access limitations for AMSM.

Biomarkers in Colorectal Cancer: Current Research and Future Prospects.

Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in detection and management through surgery, chemotherapy, radiotherapy, and immunotherapy. Novel therapeutic agents have improved survival in both the adjuvant and advanced disease settings, albeit with an increased risk of toxicity and cost. However, metastatic disease continues to have a poor long-term prognosis and significant challenges remain due to late stage diagnosis and treatment failure.

Magnetoplasmons for the-Tmodel with filled Landau levels.

Using the-Tmodel, we carried out analytical and numerical calculations for the static and dynamic polarization functions in the presence of a perpendicular magnetic field. The model involves a parameterwhich is the ratio of the hopping strength from an atom at the center of a honeycomb lattice to one of the atoms on the hexagon to the hopping strength around its rim. Our results were employed to determine the longitudinal dielectric function and the magnetoplasmon dispersion relation.

Albumin promotes the progression of fibroblasts through late G into S-phase in the absence of growth factors.

G cell cycle progression is controlled largely by growth factors in early G indicating that it is appropriate to divide and by nutrients in late G indicating sufficient raw material for cell division. We previously mapped a late G cell cycle checkpoint for lipids upstream from a mammalian target of rapamycin complex 1 (mTORC1)-mediated checkpoint and downstream from a mid-G checkpoint known as the Restriction point. We therefore investigated a role for lipids in progression through late G into S-phase.