2 results match your criteria: "Hungary. Electronic address: hrabak.andras@med.semmelweis-univ.hu.[Affiliation]"
The role of PI3K-Akt-mTOR axis in Warburg effect and its modification by specific protein kinase inhibitors in human and rat inflammatory macrophages.
Int Immunopharmacol
November 2024
Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, Budapest, H-1094 Tűzoltó u. 37-47, Hungary. Electronic address:
Article Synopsis
- The study investigates the role of the PI3K-Akt-mTOR pathway in the Warburg effect, which is a metabolic shift seen in cancer cells and inflammatory macrophages, focusing on different macrophage sources like HL-60, rat peritoneal, and human blood macrophages.
- Findings indicate that M1 polarized macrophages showed increased levels of inflammatory markers, and inhibition of the PI3K-Akt-mTOR pathway reduced these levels, highlighting its significance in metabolic changes during inflammation.
- The research also demonstrates that glucose loading influenced metabolic processes, with certain inhibitors shifting macrophage metabolism, suggesting potential therapeutic uses for these inhibitors in anti-inflammatory treatments.
Decreasing effects of protein kinase inhibitors on the expression of NOS2 and inflammatory cytokines and on phagocytosis in rat peritoneal macrophages is partly related to repolarization.
Mol Immunol
January 2023
Vichem Chemie Research Ltd., Viola u. 2., Veszprém H-8200, Hungary; Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. u. 9., Budapest H-1092, Hungary.
The JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) pathway plays a pivotal role in macrophage polarization, but other signaling routes may also be involved. The aim of this study was to reveal the relationship of activation between rat peritoneal macrophages and their polarization, to detect the signaling routes involved, and find selective protein kinase inhibitors decreasing the production of inflammatory proteins in activated peritoneal macrophages. Rat macrophages were elicited with i.
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