Critical contribution of the intracellular C-terminal region to TRESK channel activity is revealed by the epithelial Na current ratio method.

TRESK (K18.1) possesses unique structural proportions within the K background potassium channel family. The previously described TRESK regulatory mechanisms are based on the long intracellular loop between the second and the third transmembrane segments (TMS).

PrinCCes: Continuity-based geometric decomposition and systematic visualization of the void repertoire of proteins.

Grooves and pockets on the surface, channels through the protein, the chambers or cavities, and the tunnels connecting the internal points to each other or to the external fluid environment are fundamental determinants of a wide range of biological functions. PrinCCes (Protein internal Channel & Cavity estimation) is a computer program supporting the visualization of voids. It includes a novel algorithm for the decomposition of the entire void volume of the protein or protein complex to individual entities.