3 results match your criteria: "Hungary al-khrasani.mahmoud@med.semmelweis-univ.hu.[Affiliation]"
Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat.
Cells
March 2019
Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Hungary.
Intestinal dysbiosis is linked to numerous gastrointestinal disorders, including inflammatory bowel diseases. It is a question of debate if coxibs, selective inhibitors of cyclooxygenase (COX)-2, cause dysbiosis. Therefore, in the present study, we aimed to determine the effect of long-term (four weeks) selective inhibition of COX-2 on the small intestinal microbiota in the rat.
View Article and Find Full Text PDFThe Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats.
Neurochem Res
June 2018
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, Budapest, 1445, Hungary.
Opioid analgesics devoid of central side effects are unmet medical need in the treatment of acute pain (e.g. post-operative pain).
View Article and Find Full Text PDFNew Morphine Analogs Produce Peripheral Antinociception within a Certain Dose Range of Their Systemic Administration.
J Pharmacol Exp Ther
October 2016
Departments of Pharmacology and Pharmacotherapy (E.L., P.R., Z.G., L.C., M.B., K.K., Z.S.Z., P.F., S.F., M.A.) and Pharmaceutical Chemistry (A.V., S.H.), Faculty of Medicine, Semmelweis University, Budapest, Hungary; Department of Anaesthesiology and Intensive Care Medicine, Charité University Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany (S.A.M., M.S.); Department of Pharmacology and Pharmacotherapy, Medical School, Szentágothai Research Centre (K.C., Z.H.), and MTA-PTE NAP B Chronic Pain Research Group, Faculty of Medicine (Z.H.), University of Pécs, Pécs, Hungary
Growing data support peripheral opioid antinociceptive effects, particularly in inflammatory pain models. Here, we examined the antinociceptive effects of subcutaneously administered, recently synthesized 14-O-methylmorphine-6-O-sulfate (14-O-MeM6SU) compared with morphine-6-O-sulfate (M6SU) in a rat model of inflammatory pain induced by an injection of complete Freund's adjuvant and in a mouse model of visceral pain evoked by acetic acid. Subcutaneous doses of 14-O-MeM6SU and M6SU up to 126 and 547 nmol/kg, respectively, produced significant and subcutaneous or intraplantar naloxone methiodide (NAL-M)-reversible antinociception in inflamed paws compared with noninflamed paws.
View Article and Find Full Text PDF