Overlapping qubits from non-isometric maps and de Sitter tensor networks.

The emergence of a local effective theory from a more fundamental theory of quantum gravity with seemingly fewer degrees of freedom is a major puzzle of theoretical physics. A recent approach to this problem is to consider general features of the Hilbert space maps relating these theories. In this work, we construct approximately local observables, or overlapping qubits, from such non-isometric maps.

The diabetes mellitus comorbidity index in European Union member states based on the 2019 European Health Interview Survey.

Multiple chronic conditions reduce the quality of life and increase healthcare needs for people with diabetes mellitus (DM). This study aims to describe the prevalence of comorbidities associated with DM in the European Union (EU) at national and sub-national levels and to assess the utility of a comorbidity burden index. The study was carried out using microdata from European Health Interview Survey 2019 including adults aged 25 and older with DM from 26 EU member states (n = 20,042).

Nanostructural and nanomechanical alterations of photosensitized lipid membranes due to light induced formation of reactive oxygen species.

Photosensitization has a wide range of applications in vastly distant fields. Three key components must be present at the same time to trigger the related photodynamic effect: light, the photosensitizer (PS) and oxygen. Irradiating the sensitizer leads to the formation of reactive oxygen species (ROS).

Generic residue numbering of the GAIN domain of adhesion GPCRs.

The GPCR autoproteolysis inducing (GAIN) domain is an ancient protein fold ubiquitous in adhesion G protein-coupled receptors (aGPCR). It contains a tethered agonist necessary and sufficient for receptor activation. The GAIN domain is a hotspot for pathological mutations.

On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies.

Silicon integrated circuits (ICs) are central to the next-generation miniature active neural implants, whether packaged in soft polymers for flexible bioelectronics or implanted as bare die for neural probes. These emerging applications bring the IC closer to the corrosive body environment, raising reliability concerns, particularly for chronic use. Here, we evaluate the inherent hermeticity of bare die ICs, and examine the potential of polydimethylsiloxane (PDMS), a moisture-permeable elastomer, as a standalone encapsulation material.

Estrogen-regulated lateral septal kisspeptin neurons abundantly project to GnRH neurons and the hypothalamic supramammillary nucleus.

While hypothalamic kisspeptin (KP) neurons play well-established roles in the estrogen-dependent regulation of reproduction, little is known about extrahypothalamic KP-producing (KP) neurons of the lateral septum. As established previously, expression in this region is low and regulated by estrogen receptor- and GABA receptor-dependent mechanisms. Our present experiments on knock-in mice revealed that transgene expression in the LS begins at P33-36 in females and P40-45 in males and is stimulated by estrogen receptor signaling.

Labeling of oligosaccharides and N-linked glycans by a rhodamine-based fluorescent tag for analysis by capillary electrophoresis with laser-induced fluorescence and mass spectrometry detection.

In this work, we present the synthesis and application of fluorescent rhodamine B hydrazide for the derivatization of simple oligosaccharides and complex glycans using a hydrazone formation chemistry approach. The labeling conditions and the experimental setup of CE/LIF were optimized by analyzing oligosaccharide standards. The CE/LIF separations were performed in polybrene-coated capillaries eliminating the need for the purification step after derivatization.

"MoSpec": A customized and integrated system for model development, verification and validation.

Background And Objective: The growing availability of patient data from several clinical settings, fueled by advanced analysis systems and new diagnostics, presents a unique opportunity. These data can be used to understand disease progression and predict future outcomes. However, analysing this vast amount of data requires collaboration between physicians and experts from diverse fields like mathematics and engineering.

Stimulation of Piezo1 mechanosensitive channels inhibits adipogenesis in thyroid eye disease.

Context: Increased orbital tissue volume due to matrix expansion, orbital fibroblast (OF) proliferation and adipocyte differentiation are the hallmarks of thyroid eye disease (TED). Their combination with the presence of hyaluronan-bound excess water in the constrains of the bony orbit results in increased intraorbital pressure. High intraorbital pressure, along with changes in the mechanical properties of orbital tissues, may lead to the activation of mechanosensitive receptors.

Experimental and Computational Synthesis of TiO Sol-Gel Coatings.

During the experimental formation of sol-gel coatings, the colloid dispersions go through a drying process, and the structure of the coatings is formed as a result of complex chemical, colloidal, and capillary interactions. While computer simulations provide guidelines to tune and even design the nanomaterials synthesis, simulations of coating structure formation are hitherto unknown in the literature. Based on real experiments, we establish here a ReaxFF reactive force field-based molecular dynamics simulation protocol in order to investigate and determine the role of the experimental conditions on the pore structure formation in the coatings.

Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.

Introduction: Eating disorders are characterized by maladaptive eating behaviors and preoccupations around body shape, weight, and eating. The serotonin system has been among the most widely studied neurobiological factors in relation to eating disorders. Recent research also highlighted the role of oxytocin.

Queering as a tool of narrative knowledge in Ali Smith's and .

My paper analyses Ali Smith's innovative use of queering as a narrative strategy in (2007) and (2008), focusing on her transformation of narrative structures, epistemic realities, and identity through intertextual engagement. Smith's fiction queers temporality and narrative agency by reimagining classical and literary texts, including Ovid's , John Lyly's , Shakespeare's plays, and . I suggest that in , Smith reinterprets Ovid's myth of Iphis and Ianthe to celebrate fluid and transformative identities, intertwining this with feminist activism and queer desire.

Overlooked and underserved: how healthcare fails men in the pursuit of equity.

Purpose Of Review: Men face distinctive health-related challenges as a result of biological, behavioral, and sociocultural factors. In addition, the modern healthcare system does not offer men equal opportunities and options to ensure sex-specific access and delivery to health services. Men's health concerns are, indeed, often not addressed or even forgotten.

Incidence and Management of Splanchnic Vein Thrombosis in Pancreatic Diseases.

Splanchnic vein thrombosis (SVT) in pancreatic disease has a 20%-30% incidence rate, leading to increased mortality and complication rates. Therefore, the aim of this review is to summarize recent evidence about the incidence, risk factors, and management of pancreatic cancer, pancreatic cystic neoplasm-, and pancreatitis-related SVT. Doppler ultrasound should be the first imaging choice, followed by contrast-enhanced computed tomography or magnetic resonance imaging.

Divergent contribution of environmental factors to soil organic and inorganic carbon in different land use types in a forest-grassland ecotone of Inner Mongolia, China.

Understanding the comprehensive impacts of environmental factors on soil organic carbon (SOC) and soil inorganic carbon (SIC) in different land use types is of great significance for sustainable soil management. Least absolute shrinkage and selection operator (LASSO) and structural equation modelling were applied to reveal the driving mechanism of SOC, SIC and the ratio between SOC to SIC (SOC/SIC) in three major land use types (forest, grassland and farmland) in a forest-grassland ecotone (FGE) of Inner Mongolia, Northeast China. Mean annual temperature (MAT), mean annual temperature (MAP) and Enhanced Vegetation Index (EVI) were selected by LASSO as the three most important environmental factors affecting SOC, SIC and SOC/SIC in all land use types.

Corrigendum: Investigating antimicrobial resistance genes in probiotic products for companion animals.

[This corrects the article DOI: 10.3389/fvets.2024.

Inhibition of the H1 voltage-gated proton channel compromises the viability of human polarized macrophages in a polarization- and ceramide-dependent manner.

The human voltage-gated proton channel (H1) provides an efficient proton extrusion pathway from the cytoplasm contributing to the intracellular pH regulation and the oxidative burst. Although its pharmacological inhibition was previously shown to induce cell death in various cell types, no such effects have been examined in polarized macrophages albeit H1 was suggested to play important roles in these cells. This study highlights that 5-chloro-2-guanidinobenzimidazole (ClGBI), the most widely applied H1 inhibitor, reduces the viability of human THP-1-derived polarized macrophages at biologically relevant doses with M1 macrophages being the most, and M2 cells the least sensitive to this compound.

The association between adverse childhood experiences and adult cardiac function in the UK Biobank.

Aims: The importance of early life factors in determining health in later adulthood is increasingly recognized. This study evaluated the association of adverse childhood experiences (ACEs) with cardiovascular magnetic resonance (CMR) phenotypes.

Methods And Results: UK Biobank participants who had completed CMR and the self-reported questionnaire on traumatic childhood experiences were included.

Pregnancy-induced gait alterations: meta-regression evidence of spatiotemporal adjustments.

During pregnancy, women undergo significant physiological, hormonal, and biomechanical changes that influence their gait. The forward shift of the center of mass and increased joint loads often result in a "waddling gait," elevating the risk of falls. While gait changes during pregnancy have been documented, findings across studies remain inconsistent, particularly regarding variations at different pregnancy stages.

Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis.

ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading to a mutation of G: C to T: A during DNA replication. 8-Oxoguanine DNA glycosylase 1 (OGG1) is a tailored repair enzyme that recognizes 8-oxoGua in DNA duplex and initiates the base excision repair (BER) pathway to remove the lesion and ensure the fidelity of the genome.

Understanding pathways for effective interprofessional education: a thematic analysis of medical and nursing students' insights.

Background: As the healthcare field is undergoing a paradigm shift, the role of interprofessional education (IPE) is being widely accepted and recognized. Despite this, IPE interventions are not employed globally and the use of such interventions is variable. Additionally, there is an ongoing debate over how and when to employ IPE interventions.

Environmental microbial reservoir influences the bacterial communities associated with Hydra oligactis.

The objective to study the influence of microbiome on host fitness is frequently constrained by spatial and temporal variability of microbial communities. In particular, the environment serves as a dynamic reservoir of microbes that provides potential colonizers for animal microbiomes. In this study, we analyzed the microbiome of Hydra oligactis and corresponding water samples from 15 Hungarian lakes to reveal the contribution of environmental microbiota on host microbiome.