111 results match your criteria: "Hunan University of Chinese Medicine Changsha 410208[Affiliation]"
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine of Hunan Province Changsha 410208, China Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
Aurantii Fructus Immaturus and Aurantii Fructus are the dried young and immature fruits of Rutaceae, which mainly originate from the same part of lime. They are harvested from the same part with different maturity levels, which leads to different medicinal materials. It has been reported that Aurantii Fructus Immaturus and Aurantii Fructus contain flavonoids, alkaloids, volatile oils, coumarins and other components, which have a variety of pharmacological effects such as gastrointestinal disorder-alleviating, anti-anxiety, lipid metabolism-modulating, anti-inflammatory, antimicrobial, and antioxidant effects.
View Article and Find Full Text PDFThe evaluation of the effectiveness of traditional Chinese medicine(TCM) has long been a "bottleneck" issue that restricts the healthy development and internationalization of TCM. This article systematically analyzes the differences in diagnostic and treatment principles, material composition, new drug development pathways, efficacy cognition, and evaluation methodology between Chinese and Western medicine from the underlying logic of medical perspective. On this basis, it integrates the evidence elements of clinical experience, experimental research, and clinical trials, and for the first time proposes and establishes a new strategy and methodology for the evaluation of the effectiveness of TCM: the integrated evidence chain-based effectiveness evaluation of traditional Chinese medicine(iEC-Eff), forming an integrated evaluation and confirmation model of "clinical experience-experimental research-clinical trial" for the effectiveness of TCM.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
September 2024
Hunan Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Depressive Diseases Changsha 410208, China Science & Technology Innovation Center, Hunan University of Chinese Medicine Changsha 410208, China.
Zhongguo Zhong Yao Za Zhi
August 2024
the First Affiliated Hospital of Hunan University of Chinese Medicine Changsha 410007, China.
Based on the hepatocyte growth factor(HGF)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt) signaling axis, this study investigated the therapeutic effect of Paeoniae Radix Rubra and Aconiti Lateralis Radix Praeparata(PRR-ALRP) her-bal pair on acute-on-chronic liver failure(ACLF) rats and its impact on hepatocellular regeneration. The rat model of ACLF was constructed by subcutaneous and tail vein injection of bovine serum albumin combined with intraperitoneal injection of lipopolysaccharides(LPS)+D-galactosamine(D-GalN). The rats were divided into normal control(NC) group, model(vehicle) group, PRR-ALRP(5.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
June 2024
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases, Hunan University of Chinese Medicine Changsha 410208, China.
This study aims to explore the effect of Lycii Fructus and Salviae Miltiorrhizae Radix et Rhizoma(LFSMR), a drug pair possesses the function of nourishing Yin, promoting blood circulation, and brightening the eyes, in treating retinitis pigmentosa(RP)by inhibiting the gliosis of Müller cells(MCs) and inducing their reprogramming and differentiation into various types of retinal nerve cells. Twelve C57 mice were used as the normal control group, and 48 transgenic RP(rd10) mice were randomly divided into the model group, positive control group, and low and high dose LFSMR groups, with 12 mice in each group. HE staining was used to detect pathological changes in the retina, and an electroretinogram was used to detect retinal function.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
June 2024
Traditional Chinese Medicine and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
Rheumatoid arthritis(RA) is a condition in which the joints are in a weakly acidic environment. In RA, RA fibroblastlike synoviocytes( RAFLS) in the joints become abnormally activated and secrete a large amount of matrix metalloproteinases(MMPs), and the receptor protein CD44 on the cell membrane is specifically upregulated. Xuetongsu(XTS), an active ingredient in the Tujia ethnomedicine Xuetong, is known to inhibit the proliferation of RAFLS.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
June 2024
School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China.
Cinnamomum camphora chvar. borneol, a rare camphor tree variant recently identified in China, is distinguished by its high concentration of D-borneol, also known as " plant gold" due to its significant value. The essential oil extracted from this variant,rich in monoterpenes and sesquiterpenes, demonstrates a broad spectrum of pharmacological activities, including analgesic, antiinflammatory, antioxidant, cognition-enhancing, anti-bacterial, and insecticidal effects.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
July 2024
School of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
This study aimed to investigate the therapeutic effect of Shenfu Injection on mice with chronic heart failure(CHF) and its effect on macrophage polarization. C57BL/6J mice were randomly assigned to the normal and model groups. The CHF model was established by intraperitoneal injection of isoproterenol(ISO, 7.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
June 2024
Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
Zhongguo Zhong Yao Za Zhi
June 2024
School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
Ventricular remodeling after myocardial infarction(VRAMI) is a pathological phenomenon triggered by the abrupt occlusion of coronary arteries, leading to myocardial ischemia and hypoxia. This intricate process encompasses alterations in the dimensions, composition, and elasticity of the ventricular tissue and reflects pathophysiological reactions and self-repair after cardiomyocytes are damaged. The characteristic pathological manifestation of VRAMI is the presence of myocardial fibrosis(MF), wherein fibrotic cardiac tissue undergoes a loss of contractile and relaxation capacity, ultimately culminating in heart failure(HF) and significantly impacting the patient's prognosis.
View Article and Find Full Text PDF: the aim of this study was to improve the stability and bioavailability of paeoniflorin (PF) by using nanoparticle encapsulation technology. : paeoniflorin nanoparticles (PF NPs) were prepared with PLGA as the carrier using the compound emulsion method. The nanoparticles were characterised by using a Malvern laser particle sizer, transmission electron microscope (TEM), X-ray diffraction (XRD) analyser, and Fourier-transform infrared (FT-IR) spectrometry.
View Article and Find Full Text PDFAm J Transl Res
May 2024
Hunan Academy of Chinese Medicine Changsha 410013, Hunan, China.
Background: Rehabilitation after total knee arthroplasty (TKA) has become an indispensable part of the treatment strategy for degenerative joint disease. Despite some current research demonstrating efficacy of transcutaneous electrical acupoint stimulation (TEAS) for post-TKA rehabilitation, the evidence is not conclusive.
Objective: To systematically assess the evidence supporting TEAS for rehabilitation after TKA.
Zhongguo Zhong Yao Za Zhi
April 2024
Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine Changsha 410208, China School of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
This paper aims to explore the effect of Xuming Decoction in the Records of Proved Prescriptions, Ancient and Modern on cerebral ischemic injury and angiogenesis in the rat model of acute cerebral infarction. SD rats were randomized into 6 groups: sham group, model group, low-, medium-, and high-dose(5.13, 10.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
April 2024
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
Chronic heart failure(CHF) is a severe cardiovascular disease characterized by a complex pathogenesis involving myocardial structural and functional abnormalities and the activation of inflammatory responses. The NOD-like receptor thermal protein domain-associated protein 3(NLRP3) inflammasome, acting as a sensor for inflammatory cells, plays a pivotal role in the development of CHF. Research indicates that the activation of the NLRP3 inflammasome can induce inflammatory responses, leading to cardiac inflammation and impairing myocardial function, and it is correlated with the severity of CHF.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
May 2024
College of Pharmacy, Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine Changsha 410208, China.
Prunella vulgaris, aptly named for its withering at the summer solstice, displays significant variation in quality arising from differing harvest time. However, research on the chemical composition changes of its spikes at various stages is limited, and the specific metabolites remain unclear. In order to elucidate the metabolites and metabolic pathways of the spikes of P.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
May 2024
School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Key Laboratory of Germplasm Resources and Standardized Planting of Hunan Large-scale Genuine Medicinal Materials Changsha 410208, China Key Laboratory of Traditional Chinese Medicine Modernization Research in General Colleges and Universities of Hunan Province Changsha 410208, China Hunan Engineering Research Center of Standardization and Function of Chinese Herbal Decoction Pieces Changsha 410208, China.
This study aims to explore the molecular regulatory mechanism of the differential accumulation of flavonoids between 'Xianglei' and the wild type of Lonicera macranthoides. The flowers, stems, and leaves of the two varieties of L. macranthoides were collected.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
May 2024
Science and Technology Innovation Center/State Key Laboratory Cultivation Base of Chinese Medicine Powder and Innovative Drugs, Hunan University of Chinese Medicine Changsha 410208, China.
Zhongguo Zhong Yao Za Zhi
May 2024
Hunan Key Laboratory of Traditional Chinese Medicine Prevention & Treatment of Depressive Diseases Changsha 410208,China National Key Laboratory Cultivation Base of Chinese Medicinal Powder & Innovative Medicinal Jointly Established by Province and Ministry Changsha 410208,China Science & Technology Innovation Center, Hunan University of Chinese Medicine Changsha 410208,China.
The aim of this study was to explore the mechanism of icaritin-induced ferroptosis in hepatoma HepG2 cells. By bioinformatics screening, the target of icariin's intervention in liver cancer ferroptosis was selected, the protein-protein interaction(PPI) network was constructed, the related pathways were focused, the binding ability of icariin and target protein was evaluated by molecular docking, and the impact on patients' survival prognosis was predicted and the clinical prediction model was built. CCK-8, EdU, and clonal formation assays were used to detect cell viability and cell proliferation; colorimetric method and BODIPY 581/591 C1 fluorescent probe were used to detect the levels of Fe~(2+), MDA and GSH in cells, and the ability of icariin to induce HCC cell ferroptosis was evaluated; RT-qPCR and Western blot detection were used to verify the mRNA and protein levels of GPX4, xCT, PPARG, and FABP4 to determine the expression changes of these ferroptosis-related genes in response to icariin.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
March 2024
College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Research Laboratory of Traditional Chinese Medicine Property & Efficacy,Tier 3, National Administration of Traditional Chinese Medicine Changsha 410208, China Mycomedicine Research Laboratory, Hunan University of Chinese Medicine Changsha 410208, China.
Agaricus blazei is a rare medicinal and edible fungus with a crispy taste and delicious flavor. Both fruiting body and mycelium are rich in polysaccharides, sterols, terpenoids, peptides, lipids, polyphenols, and other active ingredients, which have strong pharmacological activities such as anti-tumor, lipid-lowering, glucose-lowering, immunomodulation, optimization of intestinal flora, and anti-oxidation. Therefore, it is a kind of fungal resource with a great prospect of edible and medicinal development.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
March 2024
Traditional Chinese Medicine and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
The dichloromethane fraction of Kadsura heteroclita roots was separated and purified by chromatographic techniques(e.g., silica gel, Sephadex LH-20, ODS, MCI column chromatography) and semi-preparative HPLC.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
February 2024
Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Cardiovascular and Brain Diseases,School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine Changsha 410208,China.
Network pharmacology and animal and cell experiments were employed to explore the mechanism of astragaloside Ⅳ(AST Ⅳ) combined with Panax notoginseng saponins(PNS) in regulating angiogenesis to treat cerebral ischemia. The method of network pharmacology was used to predict the possible mechanisms of AST Ⅳ and PNS in treating cerebral ischemia by mediating angiogenesis. In vivo experiment: SD rats were randomized into sham, model, and AST Ⅳ(10 mg·kg~(-1)) + PNS(25 mg·kg~(-1)) groups, and the model of cerebral ischemia was established with middle cerebral artery occlusion(MCAO) method.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
February 2024
Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases,College of Integrated Traditional and Western Medicine, Hunan University of Chinese Medicine Changsha 410208,China.