1 results match your criteria: "Hunan University Changsha 410082 P. R. China lyuan@hnu.edu.cn.[Affiliation]"
Engineering a highly selective probe for ratiometric imaging of HS and revealing its signaling pathway in fatty liver disease.
Chem Sci
July 2020
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 P. R. China
Article Synopsis
- Hydrogen polysulfides (HS) play a crucial role as signaling mediators in various physiological processes, but their specific functions in diseases like nonalcoholic fatty liver disease (NAFLD) remain unclear due to detection challenges.
- A new strategy was developed to create a ratiometric probe that selectively detects HS with improved selectivity, stability, and compatibility in biological systems.
- This probe was successfully used for the first time to image HS in a NAFLD cell model, uncovering HS generation pathways that could provide insights for future drug development targeting this liver disease.