Bmi-1 plays an important role in preventing bone aging by regulating the bone microenvironment.

Background: B-cell specific Moloney MLV insertion site-1 (Bmi-1) belongs to the polycomb group (PcG) gene and is a transcriptional suppressor to maintain appropriate gene expression patterns during development. To investigate whether the Bmi-1 gene has a corrective effect on bone senescence induced in Bmi-1 mice through regulating the bone microenvironment.

Methods: Littermate heterozygous male and female mice (Bmi-1) were used in this study.

Exploring the link between exposure to volatile organic chemicals and incidence of infertility:A cross-sectional study.

Background: Growing evidence suggests that environmental pollutants exert a detrimental impact on female fertility. Among these pollutants, volatile organic compounds (VOCs), easily encountered in the environment, have garnered significant attention as prevalent airborne contaminants. Nevertheless, a definitive consensus regarding the association between VOCs and the incidence of infertility remains elusive.

The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study.

Background: While previous studies have explored the associations and causalities among platelet count (PC), mean platelet volume (MPV), and erectile dysfunction (ED), further investigations are needed to clarify these relationships using advanced methodologies and analyzing specific populations.

Aim: To investigate the associations and causalities among PC, MPV, and ED using observational study and Mendelian randomization (MR) analysis.

Methods: A total of 114 patients with ED and 158 healthy control participants underwent a fasting blood draw to test for PC and MPV along with a comprehensive laboratory examination.

Developing Orthogonal Fluorescent RNAs for Photoactive Dual-Color Imaging of RNAs in Live Cells.

Fluorogenic RNA aptamers have revolutionized the visualization of RNAs within complex cellular processes. A representative category of them employs the derivatives of green fluorescent protein chromophore, 4-hydroxybenzlidene imidazolinone (HBI), as chromophores. However, the structural homogeneity of their chromophoric backbones causes severe cross-reactivity with other homologous chromophores.

Reducing Measurement Deviation by Metastable DNA Probes for Aptamer Thermodynamic Characterization.

DNA reaction equilibrium-based calculations have great potential in thermodynamic characterization, but their widespread applications are hindered by significant measurement deviation of equilibrium concentration. Here, we report the advantages of metastable DNA hybridization in reducing quantification deviation of equilibrium concentration and propose a universal and standardized strategy for measuring aptamer binding energy, termed metastable DNA reference calorimetry (MDRC). We built different MDRC-based algorithms tailored to different aptamer binding models, enabling the calculation of thermodynamic parameters for aptamers with one or more binding sites.

Multiple Electron Transfers Enable High-Capacity Cathode Through Stable Anionic Redox.

Single-electron transfer, low alkali metal contents, and large-molecular masses limit the capacity of cathodes. This study uses a cost-effective and light-molecular-mass orthosilicate material, KFeSiO, with a high initial potassium content, as a cathode for potassium-ion batteries to enable the transfer of more than one electron. Despite the limited valence change of Fe ions during cycling, KFeSiO can undergo multiple electron transfers via successive oxygen anionic redox reactions to generate a high reversible capacity.

CellMsg: graph convolutional networks for ligand-receptor-mediated cell-cell communication analysis.

The role of cell-cell communications (CCCs) is increasingly recognized as being important to differentiation, invasion, metastasis, and drug resistance in tumoral tissues. Developing CCC inference methods using traditional experimental methods are time-consuming, labor-intensive, cannot handle large amounts of data. To facilitate inference of CCCs, we proposed a computational framework, called CellMsg, which involves two primary steps: identifying ligand-receptor interactions (LRIs) and measuring the strength of LRIs-mediated CCCs.

Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024.

Background: Prostate cancer (PCa) ranks as the second most common disease among men and the fourth most prevalent cancer worldwide. Enhanced glycolysis and excessive lactate secretion are recognized as critical factors driving the progression of various cancers. This study systematically investigated the research trends associated with glycolysis in PCa through bibliometric analysis.

Boosting One- and Two-Photon Excited Fluorescence of Interpenetrated Tetraphenylethene-Based Metal-Organic Frameworks (TPE-MOFs) by Linker Installation.

Immobilizing organic chromophores within the rigid framework of metal-organic frameworks (MOFs) augments fluorescence by effectively curtailing molecular motions. Yet, the substantial interspaces and free volumes inherent to MOFs can undermine photoluminescence efficiency, as they partially constrain intramolecular dynamics. In this study, we achieved optimization of both one- and two-photon excited fluorescence by incorporating linkers into an interpenetrated tetraphenylethene-based MOF (TPE-MOF).

Graphene oxide-based fluorescent biosensors for pathogenic bacteria detection: A review.

Background: Pathogenic bacteria are widespread in nature and can cause infections and various complications, thereby posing a severe risk to public health. Therefore, simple, rapid, sensitive, and cost-effective methods must be developed to detect pathogenic bacteria. Biosensors are prominent platforms for detecting pathogenic bacteria owing to their high sensitivity, specificity, repeatability, and stability.

Turning waste into wealth: Enzyme-activated DNA sensor based on reactant recycle for spatially selective imaging microRNA toward target cells.

Background: Amplified imaging of microRNA (miRNA) in cancer cells is essential for understanding of the underlying pathological process. Synthetic catalytic DNA circuits represent pivotal tools for miRNA imaging. However, most existing catalytic DNA circuits can not achieve the reactant recycling operation in cells and in vivo.

Elucidating the roles of voltage sensors in Na1.9 activation and inactivation through a spider toxin.

The gating process of voltage-gated sodium (Na) channels is extraordinary intrinsic and involves numerous factors, such as voltage-sensing domain (VSD), the N-terminus and C-terminus, and the auxiliary subunits. To date, the gating mechanism of Na channel has not been clearly elucidated. Na1.

The pathogenesis of depression: Roles of connexin 43-based gap junctions and inflammation.

Background: Depression is a leading chronic mental illness worldwide, characterized by anhedonia and pessimism. Connexin is a kind of widely distributed protein in the body. Connexin 43 (Cx43) plays an important role in the pathogenesis of depression.

Palladium Nanosheet Enables Synergistic Electrocatalytic Dehalogenation via Direct and Indirect Electron Transfer Mechanisms.

Electrocatalytic dehalogenation is a promising method for the remediation of chlorinated organic pollutants. The dehalogenation performance is controlled by catalytic activity, and the underlying electrocatalytic dehalogenation mechanisms need to be carefully investigated for guiding the design of catalyst. Here we report the preparation of a new Pd-based catalyst with a nanosheet structure (Pd NS) by a simple wet-chemical reduction method.

Investigating non-target site resistance to pyroxsulam in a glyphosate-resistant Lolium rigidum population.

Background: Resistance to multiple herbicides is common in Lolium rigidum. Here, resistance to acetolactate synthase (ALS)- and susceptibility to acetyl-CoA carboxylase (ACCase)-inhibiting herbicides was confirmed in a glyphosate-resistant L. rigidum population (NLR70) from Australia and the mechanisms of pyroxsulam resistance were examined.

Ensemble All Time-Scale Decomposition Method and Its Application in Bevel Gear Fault Diagnosis.

All time-scale decomposition (ATD) is a non-parametric adaptive signal decomposition method, which relies on zero-crossing points and extreme points to jointly construct the baseline, achieving the suppression of modal mixing caused by the proximity of component frequencies. However, ATD is unable to solve mode mixing induced by noise. To improve this defect, a new noise-assisted signal decomposition method named ensemble all time-scale decomposition (EATD) is proposed in this paper.

L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress.

L. oligo-polysaccharides (CIOs), obtained from L., is a mixture of oligosaccharides and polysaccharides.

Pathophysiology and Management Strategies for Post-Stroke Spasticity: An Update Review.

Post-stroke spasticity (PSS), characterized by a velocity-dependent increase in muscle tone and exaggerated reflexes, affects a significant portion of stroke patients and presents a substantial obstacle to post-stroke rehabilitation. Effective management and treatment for PSS remains a significant clinical challenge in the interdisciplinary aspect depending on the understanding of its etiologies and pathophysiology. We systematically review the relevant literature and provide the main pathogenic hypotheses: alterations in the balance of excitatory and inhibitory inputs to the descending pathway or the spinal circuit, which are secondary to cortical and subcortical ischemic or hemorrhagic injury, lead to disinhibition of the stretch reflex and increased muscle tone.

Phosphoenolpyruvate and Related Metabolic Pathways Contribute to the Regulation of Plant Growth and Development.

Phosphoenolpyruvate (PEP) plays a key role in the development of plants and exists in a wide variety of species. Research on the metabolic activities of PEP in plants has received increasing attention. PEP regulates multiple processes in plant growth and development.

Improving the Electrochemical and Electrochromic Properties of Copolymerized 3,4-Ethylenedioxythiophene with Pyrene.

Pyrene (Pr) was used to improve the electrochemical and electrochromic properties of polythiophene copolymerized with 3,4-ethylenedioxythiophene (EDOT). The corresponding product, poly(3,4-ethylenedioxythiophene-co-Pyrene) (P(EDOT-co-Pr)), was successfully synthesized by electrochemical polymerization with different monomer concentrations in propylene carbonate solution containing 0.1 M lithium perchlorate (LiClO/PC (0.

Crosslinking-induced compatibility and toughness enhancement in poly(lactic acid)/poly(3-hydroxybutyrate-co-4-hydroxybutyrate) blends with epoxidized soybean oil.

Polylactide (PLA) is inherently brittle and lacks ductility, which greatly restricts its range of applications. In order to address these issues, we blended PLA with biodegradable poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)), and introduced epoxidized soybean oil (ESBO) as a reactive modifier to enhance the properties of the PLA/P(3HB-co-4HB) blends. Furthermore, we used theoretical calculations, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Soxhlet extraction, differential scanning calorimetry (DSC), polarising optical microscopy (POM), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and mechanical testing to investigate the compatibility, crystallization behavior, microstructure, thermal and mechanical properties of the PLA/P(3HB-co-4HB)/ESBO blends.

Study on the adsorption performance of carbon-magnetic modified sepiolite nanocomposite for Sb(V), Cd(II), Pb(II), and Zn(II): Optimal conditions, mechanisms, and practical applications in mining areas.

A carbon-magnetic modified sepiolite nanocomposite (γ-FeO/SiO-Mg(OH)@BC) was synthesized using a hydrothermal method, consisting of γ-FeO, activated sludge biochar (BC), and alkali-modified sepiolite. Its ability to remove heavy metals such as Sb(V), Pb(II), Cd(II), and Zn(II) was investigated through adsorption experiments. Using response surface optimization, the optimal adsorption conditions were determined: adsorption time = 3.

The impact of art and design competencies on positive psychological qualities among college students in Hainan Province: The chain mediating roles of teacher support and learning adaptability.

Research Objective: Early adulthood students are at the peak of their rapid psychological development and face an important transition from "mere cognition" to "social cognition" and experiences or guidance during this period are particularly important for psychological quality. From a positive psychology perspective, this study examines the impact of art and design competencies in college students on their positive psychological qualities and analyzes the mediating roles of teacher support and learning adaptability.

Methods: Using the Art and Design Competencies Scale for College Students, the Chinese College Students' Positive Psychological Qualities Scale, the Learning Adaptability Scale, and the Teacher Support Scale, a survey was conducted among 950 college students majoring in art.

Trace detection of antibiotics in wastewater using tunable core-shell nanoparticles SERS substrate combined with machine learning algorithms.

Surface-enhanced Raman scattering (SERS) show great potential for rapid and highly sensitive detection of trace amounts of contamination from the environment in the surface aquatic ecosystem. The widespread use of antibiotics has resulted in serious degradation of the water environment in the past few years, and their substantial residual contamination of wastewater has a harmful effect on ecosystems, which is associated with the development of antibiotic-resistant bacterial strains. However, in this study, a novel approach of core-shell nanoparticles GNRs@1,4-BDT@Ag was used for the quantitative measurement of the concentration of antibiotics in wastewater solutions using the SERS technique coupled with computational methods.