Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway.

Per- and polyfluoroalkyl substances (PFAS) are synthetic perfluorinated compounds known for their persistence in the environment and reproduction toxicity. PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), have been identified in the follicular fluid of infertile women. However, the specific of PFOA and PFOS mixture on oocyte quality and female fertility remain unclear.

Dual-mode ultrasensitive detection of acute leukemia gene Pax-5a based on smart DNA programmed dendrimer.

Accurate and sensitive detection of Pax-5a gene is the basis of early diagnosis and prediction of acute leukemia. This research aims to develop a universal dual-mode sensing method enables ultrasensitive gene detection based on smart control of DNA amplification by nucleic acid beacons e to form programmed dendrimer. The Pax-5a target gene triggers the opening of smart gate hairpin probe (Hp), exposing the stem sequence as the primer to bind with padlock probe for rolling circle amplification (RCA).

Mechanism of oxygen vacancy engineering CoO/FeO regulated electrocatalytic reduction of nitrate to ammonia.

To enhance the activity of the nitrate reduction reaction (NORR), the development of oxygen vacancies electrocatalysts is a promising approach for improving the efficiency of ammonia synthesis. However, the mechanism by which oxygen vacancies regulate NORR to ammonia remains poorly understood. In this study, a series of CoO/FeO composite catalysts derived from ZIF-67 containing oxygen vacancies (OVs) were synthesized to elucidate the role of OVs on the activity and selectivity of ammonia synthesis.

An Ultrastable Integrated Anode with ∼95 wt.% SiO via In Situ Electrode-Scale Conformal Coating.

SiO-based anodes, considered the most promising candidate for high-energy density batteries, have long been bothered by mechanical integrity issues. Research efforts focus on particle modifications, often overlooking the enhancement of interparticle connections, which can reduce the active material content within the electrode. Herein, an integrated electrode with strong covalent bonding at the electrode scale is designed, achieving excellent mechanical stability with ∼95 wt.

Supramolecular ionogels enable highly efficient electrochromism.

Ionogels are a promising solution to improve the functionality of electrochromic devices (ECDs) by solving issues related to traditional liquid electrolytes, such as volatility, toxicity, and leakage. However, manufacturing ionogels is complicated as it often involves cross-linking polymerization or chemical sol-gel processes, requiring large amounts of inorganic or polymeric gelators. This results in low ionic conductivity and poor ECD performance.

Astragali Radix-Angelicae Sinensis Radix inhibits the activation of vascular adventitial fibroblasts and vascular intimal proliferation by regulating the TGF-β1/Smad2/3 pathway.

Ethnopharmacological Relevance: Astragali Radix-Angelicae Sinensis Radix is an important traditional Chinese medicine used for the treatment of cardiovascular diseases. Our previous studies have shown that Astragali Radix-Angelicae Sinensis Radix can inhibit vascular intimal hyperplasia and improve the blood vessel wall's ECM deposition, among which six main active components can be absorbed into the blood, suggesting that these components may be the main pharmacodynamic substances of Astragali Radix-Angelicae Sinensis Radix against vascular intimal hyperplasia.

Aim Of The Study: A mouse model of atherosclerosis was used to study the relationship between the anti-intimal hyperplasia effect of Astragali Radix-Angelicae Sinensis Radix and the inhibition of VAF activation and ECM synthesis.

The clinical value of local consolidative therapy for oligo-residual disease in PD-1/PD-L1 inhibitors-treated non-small cell lung cancer.

Background: Few real-world studies exist regarding the clinical value of local consolidative therapy (LCT) for oligo-residual disease (ORD) in NSCLC patients treated with immune checkpoint inhibitors. Therefore, we retrospectively evaluated whether LCT could improve the prognosis of NSCL patients with ORD after effective first-line PD-1/PD-L1 inhibitors treatment.

Methods: A total of 132 patients with metastatic NSCLC who had received first-line PD-1/PD-L1inhibitors-based systemic treatment and developed ORD (defined as residual tumors limited to three organs and five lesions) were included.

The role of blended learning in improving medical students' academic performance: evidence from Pakistan.

Objective: The study examines the role of blended learning in improving medical students' academic performance through self-regulatory learning and technological competence and identifies the moderating role of perceived institutional support in the relationships between self-regulatory learning, perceived teacher credibility, technological competencies, and academic performance.

Methods: The study was based on behavioral learning theory as a theoretical framework, and an adapted questionnaire was used to collect the data. In total, 275 medical students participated in the study, and the data was analyzed using structural equation modeling techniques with SmartPLS.

The therapeutic effects of induced pluripotent stem cell-derived mesenchymal stem cells on Parkinson's disease.

Parkinson's disease (PD), characterized by progressive degeneration of dopaminergic neurons in substantia nigra, has no disease-modifying therapy. Mesenchymal stem cell (MSC) therapy has shown great promise as a disease-modifying solution for PD. Induced pluripotent stem cell-derived MSC (iMSC) not only has stronger neural repair function, but also helps solve the problem of MSC heterogeneity.

Coenzyme Q10 Alleviates Silicosis Fibrosis Inhibiting Ferroptosis in Mice.

Background/aim: Silicosis, the most severe type of occupational pneumoconiosis, leads to diffuse pulmonary fibrosis without specific therapy. Ferroptosis is triggered by reactive oxygen species (ROS) and Fe overload-induced lipid peroxidation, which is involved in the progression of pulmonary fibrosis. As an important coenzyme in the process of aerobic respiration, Coenzyme Q10 (CoQ10) can enhance mitochondrial function and energy supply and reduce malondialdehyde (MDA) to limit the risk of fibrosis.

Advances in research on the mechanism of tsRNA action in tumours.

tsRNA is a class of non-coding RNAs derived from mature or precursor tRNAs. In recent years, more and more studies have explored the correlation between tsRNAs and tumours. tsRNAs can affect the biological behaviours of tumour cells such as proliferation, apoptosis and metastasis by regulating gene expression, protein translation or post-transcriptional regulation.

Fast STEM image simulation in low-energy transmission electron microscopy by the accurate Chen-van-Dyck multislice method.

The Chen-van-Dyck (CVD) formulation as a rigorous numerical solution to the Schrödinger equation has been demonstrated being the only accurate multislice method for calculating diffraction and imaging in low-energy transmission electron microscopy. The CVD formulation not only considers the forward scattering effects but also includes the backscattering effects. However, since its numerical computation has to be performed in real-space, the CVD method may suffer from divergence and inefficiency in computing time, especially when used for low-energy scanning transmission electron microscopy (STEM) image simulation.

Resource utilization of waste solar photovoltaic panels for preparation of microporous silicon nanoparticles.

With the exponential growth of global photovoltaic (PV) installed capacity, the quantity of discarded PV modules continues to rise. This study innovatively explored the sustainable recovery and utilization of raw materials from discarded solar panels, focusing on the transformation of recycled silicon into microporous silica nanoparticles (MSN). Low toxic organic solvent ethyl acetate (EA) was for the first time utilized to reduce the viscosity of ethylene-vinyl acetate (EVA) and facilitated its removal.

Exploring micro(nano)plastics toxicity from an environmental management perspective: Zebrafish as a vital bridge for assessing potential human health risks.

The pollution stemming from the unwarranted utilization and inadequate disposal of plastic products is undergoing rapid escalation. The problem of micro(nano)plastics (MNPs) pollution has recently garnered significant attention, and the issue of human exposure to MNPs cannot be disregarded. However, the present state of research concerning human exposure to MNPs remains in its early stages.

Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics.

Infections caused by gram-negative pathogens continue to be a major risk to human health because of the innate antibiotic resistance endowed by their unique cell membrane architecture. Nature has developed an elegant solution to target gram-negative strains, namely by conjugating toxic antibiotic warheads to a suitable carrier to facilitate the active import of the drug to a specific target organism. Microcin C7 (McC) is a Trojan horse peptide-conjugated antibiotic that specifically targets enterobacteria by exploiting active import through oligopeptide transport systems.

Research on multi-label recognition of tongue features in stroke patients based on deep learning.

Stroke has become the leading cause of disability in adults worldwide. Early precise rehabilitation intervention is crucial for the recovery of stroke patients, with the key lying in accurately identifying patients' physical characteristics during the rehabilitation phase. Compared to diagnostic techniques such as medical neuroimaging, traditional Chinese medicine(TCM) tongue diagnosis offers good accessibility and ease of application.

A fast-modeling framework for personalized human body models based on a single image.

Finite element human body models (HBMs) are the primary method for predicting human biological responses in vehicle collisions, especially personalized HBMs that allow accounting for diverse populations. Yet, creating personalized HBMs from a single image is a challenging task. This study addresses this challenge by providing a framework for HBM personalization, starting from a single image used to estimate the subject's skin point cloud, the skeletal point cloud, and the relative positions of the skeletons.

First-line chemotherapy with tislelizumab for patients with extensive-stage small cell lung cancer: a cost-effectiveness analysis.

The Phase 3 RATIONALE-312 trial (NCT04005716) showed that tislelizumab plus chemotherapy led to a noteworthy enhancement resulted in a significant improvement in overall survival among patients diagnosed with extensive-stage small-cell lung cancer (ES-SCLC) compared to chemotherapy alone. The treatment also had an acceptable level of safety. Nevertheless, the debate over the efficacy of implementing several treatment plans in competition continues due to the significant expenses involved.

Analysis of diagnostic genes and molecular mechanisms of Crohn's disease and colon cancer based on machine learning algorithms.

Crohn's disease (CD) is a chronic inflammatory bowel condition, and colon adenocarcinoma (COAD), as one of the most prevalent malignant tumors of the digestive tract, has been indicated by research to have a close association with CD. This study employs bioinformatics techniques to uncover the potential molecular links between CD and COAD. In this study, two data series related to CD were identified from the Gene Expression Omnibus (GEO) database under specific criteria, and relevant COAD gene data were obtained from The Cancer Genome Atlas (TCGA).