Efficient voltammetric platform combining a molecularly imprinted polymer and silver-nanoparticle-decorated black phosphorus nanosheets for selective determination of Gatifloxacin.

An ultrasensitive and selective voltammetric platform combined a molecularly imprinted poly(pyrrole) membrane with Ag-nanoparticle-functionalized black phosphorus nanosheets (MIP/BPNS-AgNPs) was developed for trace GAT detection. The physicochemical properties of the MIP/BPNS-AgNPs were studied by various spectroscopic and electrochemical techniques. BPNS-AgNPs improved the ambient stability and electrochemical activity of the BPNS and possessed a large surface area for accommodating abundant templates to produce specific imprinted sites.

Organic Metasurfaces with Contrasting Conducting Polymers.

Conducting polymers have emerged as promising active materials for metasurfaces due to their electrically tunable states and large refractive index modulation. However, existing approaches are often limited to infrared operation or single-polymer systems, restricting their versatility. In this Letter, we present organic metasurfaces featuring dual conducting polymers, polyaniline (PANI) and poly(3,4-ethylenedioxythiophene) (PEDOT), to achieve contrasting dynamic optical responses at visible frequencies.

Porphyrin-Based Metal-Organic Framework Photocatalysts: Structure, Mechanism and Applications.

In recent years, porphyrins have been frequently reported as photocatalysts due to their fascinating photochemical properties. However, porphyrins have the same shortcomings as other homogeneous photocatalysts, such as poor stability and difficulty in recovering. To solve this problem, it is a good strategy to form a porphyrin-based metal-organic framework (PMOF) by modifying porphyrin functional groups and adding metals as nodes to connect and control the arrangement of porphyrins.

Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases.

Diverse liver diseases are characterised by late diagnosis and rapid progression and have become one of the major threats to human health. To delay the transition from benign tissue lesions to a substantial organ injury, scientists have gradually applied natural compounds derived from plants as a complementary therapy in the field of hepatology. Ginseng (Panax ginseng C.

Chitosan-based injectable porous microcarriers with enhanced adipogenic differentiation and angiogenesis for subcutaneous adipose tissue regeneration.

Chitosan is a promising biomaterial for tissue engineering, but its functionality is limited by a lack of bioactive sites. This study develops chitosan/amniotic membrane microcarriers to enhance vascularization and tissue regeneration for subcutaneous adipose tissue. The incorporation of decellularized amniotic membrane enhances the bioactivities of chitosan in promoting cell differentiation and angiogenesis.

Effectiveness of nurse-led care in patients with rheumatoid arthritis: a systematic review and meta-analysis.

Objectives: This study sought to assess the effectiveness of nurse-led care (NLC) in patients with rheumatoid arthritis (RA).

Methods: We conducted a comprehensive search of the Cochrane Library, Web of Science, PubMed, Embase, CINAHL, ClinicalTrials.gov databases and the references from relevant literature published prior to May 2023.

Actuation performance of MXenes in response to moisture gradients: A systematic investigation.

Humidity-responsive actuators (HRA) have garnered significant interest across various domains. Since 2020, MXene have been extensively studied for their potential in HRA, demonstrating remarkable performance. Thus far, more than 70 MXene materials have been found.

Two-dimensional identification of lower limb gait features based on the variational modal decomposition of sEMG signal and convolutional neural network.

Background: Gait feature recognition is crucial to improve the efficiency and coordination of exoskeleton assistance. The recognition methods based on surface electromyographic (sEMG) signals are popular. However, the recognition accuracy of these methods is poor due to ignoring the correlation of the time series of sEMG signals.

Enhancing university students' engagement in studying assistive technology by case-based active learning: a pilot study in Hong Kong.

Assistive technology (AT) professionals are in pressing need with nowadays growing aged/disabled population, so as well-designed higher education programs in this field. This study designed and implemented a case-based active learning approach within an undergraduate course related to AT in Hong Kong, and assessed its impact on enhancing student engagement over two academic years. A total of twelve multimedia patient case dossiers on six major physical disabilities were created.

The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study.

Objective: This study aims to elucidate the therapeutic efficacy and safety of a taxane-based chemotherapy in combination with immune checkpoint inhibitors regimen in patients diagnosed with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).

Methods: We retrospectively collected clinical data from 154 patients who received at least two cycles of PD-1 inhibitors in combination with a taxane-based chemotherapy as first-line treatment in seven hospitals in Hunan Province, between December 2018 and December 2023. These patients were subjected to long-term follow-up.

Effect of magnetized water on the fundamental grouting properties of cement grout under varying magnetization conditions.

The development and modification of grouting materials constitute crucial factors influencing the effectiveness of grouting. Given the pivotal role of water in the hydration of cement-based composite materials and construction processes, this study proposes an exploratory approach using green, economical magnetized water technology to enhance the performance of cement grouts. The research systematically investigates the effects of magnetized water on the fundamental grouting properties (stability, rheological behavior, and stone body strength) of cement grouts, prepared under varying magnetization conditions (including magnetic intensity, water flow speed, and cycle times).

DrugAssist: a large language model for molecule optimization.

Recently, the impressive performance of large language models (LLMs) on a wide range of tasks has attracted an increasing number of attempts to apply LLMs in drug discovery. However, molecule optimization, a critical task in the drug discovery pipeline, is currently an area that has seen little involvement from LLMs. Most of existing approaches focus solely on capturing the underlying patterns in chemical structures provided by the data, without taking advantage of expert feedback.

Effectiveness and Safety of Glue-based Dural Closure in Cranial Surgery: A Retrospective Cohort Study.

Dural closure is a crucial step in cranial surgery, essential for preventing complications like cerebrospinal fluid leakage, wound infections, and meningitis. Traditional suturing techniques, however, pose challenges such as technical difficulty and the potential for tissue damage. This retrospective study aimed to assess the safety and effectiveness of a nonsuture dural closure method using medical glue for direct adhesion of a patch to the dura mater.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

P-Dopant with Spherical Anion for Stable n-i-p Perovskite Solar Cells.

Li-TFSI/t-BP is the most widely utilized p-dopant for hole-transporting materials (HTMs) in state-of-the-art perovskite solar cells (PSCs). However, its nonuniformity of doping, along with the hygroscopicity and migration of dopants, results in the devices that exhibit limited stability and performance. This study reports the use of a spherical anion of the p-dopant, regulated by its radius and shape, as an alternative to the linear TFSI- anion.

Copper/iron controlled regioselective 1,2-carboazidation of 1,3-dienes with acetonitrile and azidotrimethylsilane.

Carboazidation and diazidation were carried out on 1,3-diene compounds using TMSN as the azide source and MeCN as the cyanoalkylation reagent. This method exhibits excellent functional group tolerance, a broad substrate range, and a short reaction time, providing an effective pathway for synthesizing valuable azides. Our report introduces an unprecedented strategy for the carboazidation and diazidation of 1,3-dienes, with mechanism studies indicating that the reaction involves a radical pathway.

Pretreatment neutrophil-to-lymphocyte ratio is associated with immunotherapy efficacy in patients with advanced cancer: a systematic review and meta-analysis.

This study aimed to systematically investigate the value of the pre-treatment neutrophil-to-lymphocyte ratio (NLR) in prognosticating the outcome of patients with advanced cancer receiving immunotherapy. We searched Embase, PubMed, Web of Science, and Cochrane Library to identify studies about cancer patients with immunotherapy until November 29, 2024. Retrospective or prospective cohort studies with pretreatment NLR data were included.

Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to purine metabolism-associated genes.

Sepsis, characterized as a systemic inflammatory response triggered by pathogen invasion, represents a continuum that may progress from mild systemic infection to severe sepsis, potentially culminating in septic shock and multiple organ dysfunction syndrome. A pivotal element in the pathogenesis and progression of sepsis involves the significant disruption of oncological metabolic networks, where cells within the pathological milieu exhibit metabolic functions that diverge from their healthy counterparts. Among these, purine metabolism plays a crucial role in nucleic acid synthesis.

A stable open-shell peri-hexacene with remarkable diradical character.

[n]Peri-acenes ([n]PA) have attracted great interest as promising candidates for nanoelectronics and spintronics. However, the synthesis of large [n]PA (n > 4) is extremely challenging due to their intrinsic open-shell radical character and high reactivity. Herein, we report the successful synthesis and isolation of a derivative (1) of peri-hexacene in crystalline form.

General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines.

(Hetero)polyaryl amines are extensively prevalent in pharmaceuticals, fine chemicals, and materials but the intricate and varied nature of their structures severely restricts their synthesis. Here, we present a selective multicomponent cycloaromatization of structurally and functionally diverse amine substrates for the general and modular synthesis of (hetero)polyaryl amines through copper(I)-catalysis. This strategy directly constructs a remarkable range of amino group-functionalized (hetero)polyaryl frameworks (194 examples), including naphthalene, binaphthalene, phenanthren, benzothiophene, dibenzothiophene, benzofuran, dibenzofuran, quinoline, isoquinoline, quinazoline, and others, which are challenging or impossible to obtain using alternative methods.

Electronic structure formed by YO-doping in lithium position assists improvement of charging-voltage for high-nickel cathodes.

High-capacity power battery can be attained through the elevation of the cut-off voltage for LiNiCoMnO high-nickel material. Nevertheless, unstable lattice oxygen would be released during the lithium deep extraction. To solve the above issues, the electronic structure is reconstructed by substituting Li ions with Y ions.