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Sirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C Motif) Ligand 2 Secretion through the NF-κB Signaling Pathway.
Am J Pathol
December 2024
The Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, The Key Laboratory of Model Animals and Stem Cell Biology of Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Pharmaceutical Science, Changsha, China. Electronic address:
Article Synopsis
- The progression of Alcohol-associated liver disease (ALD) involves increased gut permeability due to ethanol, leading to bacterial products entering the bloodstream and causing liver inflammation and damage.
- The study used mice without the SIRT7 gene in myeloid cells, finding that this knockout reduced liver injury and inflammation caused by alcohol while minimally impacting lipid metabolism.
- Identification of CCL2 as a key target affected by SIRT7 highlights how its knockout hinders macrophage CCL2 secretion and monocyte recruitment, suggesting that targeting SIRT7 could provide new treatment strategies for ALD.