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A logic-activated nanoswitch for killing cancer cells according to assessment of drug-resistance.

RSC Adv

September 2024

Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research Ministry of Education, Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal University Changsha 410081 China

A logic-activated nanoswitch that could diagnose the differences between drug-resistant and non-drug-resistant cancer cells and control the release of drugs was developed for enhanced chemo-gene therapy using a standalone system. Compared to traditional treatments, the nanoswitch displayed improved anti-tumor efficiency .

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