Development and verification of a nomogram for predicting portal vein tumor thrombosis in hepatocellular carcinoma.

Objective: To develop a nomogram to predict the risk of portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) patients.

Methods: Patients diagnosed with HCC at Hunan Provincial People's Hospital between January 2010 and January 2022 were enrolled. Data on demographic characteristics, comorbidities, and laboratory tests were collected.

A biofuel cell of (methyl violet/AuNPs)/FTO photoanode and bilirubin oxidase/CuCoO bio-photocathode inspired by the photoelectrochemistry activities of fluorescent materials/molecules.

Herein, we discuss the idea that fluorescent materials/molecules should logically show potential photoelectrochemistry (PEC) activity, and, in particular, the PEC of fluorescent small molecules (previously usually acting only as dye sensitizers for conventional semiconductors) is explored. After examining the PEC activities of some typical inorganic or organic fluorescent materials/molecules and by adopting methyl violet (MV) with the highest PEC activity among the examined fluorescent small molecules, a new and efficient (MV/Au nanoparticles (AuNPs))/fluorine-doped tin oxide (FTO) photoanode without conventional semiconductor(s) is prepared by layer-by-layer alternating the electrodeposition of AuNPs and the adsorption of MV. A bilirubin oxidase (BOD)/CuCoO/FTO bio-photocathode is prepared by electrodeposition, calcination and cast-coating.

A new genus, gen. nov., with two new species and the first description of the female of Long & Yu, 2022 (Arachnida, Araneae, Philodromidae) from China.

Three species of the spider family Philodromidae are reported from the south of China. A new genus, , is described from Jiangxi, Fujian, and Hunan Provinces. It can be distinguished from other genera of Philodromidae by the tegular apophysis of the palp and the cymbial process, as well as by its uniquely striped abdomen.

Taxonomic notes of jumping spiders (Araneae, Salticidae) from Guangxi, Hainan, Sichuan, Xizang and Yunnan, China.

Twenty-one new species of jumping spiders from five provinces of South China are described: (♂), (♂♀), (♂♀), (♂♀), (♂♀), (♂), (♂♀), (♂♀), (♀), (♂♀), (♂♀), (♂♀), (♂♀), (♂♀), (♂♀), (♂♀), (♂), (♂♀), (♂♀), (♂♀), and (♂♀). Prószyński, 2016, is proposed as a junior synonym of Prószyński, 2016. Three new combinations are proposed: (Andreeva, Hęciak & Prószyński, 1984), and (Wanless, 1984), transferred from , and (Peng, Gong & Kim, 2000), transferred from Thorell, 1869.

Acid-responsive singlet oxygen nanodepots.

The singlet oxygen carrier addresses the challenges of traditional photodynamic therapy (PDT), which relies on the presence of oxygen within solid tumors and struggles with light penetration issues. However, the inability to control the release of singlet oxygen has hindered precise treatment applications. Here, we introduce an acid-responsive singlet oxygen nanodepot (aSOND) designed to overcome this limitation.

Sub--benziporphyrin: a subcarbaporphyrinoid and its B complex with an unprecedented planar tridentate 14π-aromatic network.

Sub--benziporphyrins were synthesized by Pd-catalyzed cross-coupling of ,'-diboryl--benzitripyrrane with 9,10-bis(1,1-dibromomethylenyl)anthracene. Reaction of sub--benziporphyrin with PhBCl and triethylamine gave its B-phenyl complex as a tetracoordinate nonaromatic B complex. In contrast, the reaction with BBr and triethylamine furnished a neutral B porphyrinoid with a planar and triangular coordination as the first example, in which the -phenylene unit was partially reduced, allowing for the global 14π-aromatic circuit.

Sotorasib inhibits ubiquitination degradation of TXNIP and suppresses glucose metabolism in mutant bladder cancer.

Bladder cancer is the most common malignant tumor of the urinary system. Currently, treatment strategies for bladder cancer remain limited, highlighting the urgent need to explore novel therapeutic approaches. Sotorasib, the first successful small molecule drug targeting KRAS, has been approved for treating non-small cell lung cancer (NSCLC), but it has not yet been studied in bladder cancer.

Proteomic analysis of serum from a MeCP2 patient reveals an arginine biosynthesis pathway affected by the p.Lys254* variant.

Key Clinical Message: This study reports a Chinese male patient with a novel MeCP2 p.Lys254*variant. Upon birth, the patient presented with typical symptoms, such as abnormal electroencephalogram, immature sleep rhythm, hypotonia, feeding difficulties, pulmonary fluid accumulation, horizontal fissures in the lungs, hypoventilation, and heart defects.

Protection against cigarette smoke-induced chronic obstructive pulmonary disease via activation of the SIRT1/FoxO1 axis by targeting microRNA-132.

Objective: To investigate the biological role of miR-132 in a murine model of chronic obstructive pulmonary disease (COPD) via activation of the SIRT1/FoxO1 axis.

Methods: COPD was induced in C57BL/6J male mice by exposing them to cigarette smoke (CS) for 8 weeks. A miR-132 knockout mouse model was used to assess the role of miR-132 in CS-induced COPD.

Individualized post-operative prediction of cochlear implantation outcomes in children with prelingual deafness using functional near-infrared spectroscopy.

Objective: The goal of this study was to develop an objective measure and predictor of cochlear implantation (CI) outcomes using functional near-infrared spectroscopy (fNIRS) for young children with prelingual deafness.

Methods: Sound-evoked hemodynamic responses were recorded from auditory and language-related cortical regions of 47 child CI recipients (35.47 ± 17.

Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice.

As a natural pentacyclic triterpenoid, oleanolic acid has hepatoprotective, anti-inflammatory, and antioxidant activities. This work performed the in vitro experiments and animal assay to explore whether oleanolic acid alleviates lipid accumulation induced by high-fat diet by mediating PPARγ. Oil red O staining showed that oleanolic acid can reduce lipid accumulation in HepG2 cells, which were treated with oleic acid and palmitic acid.

Autocatalysis-Integrated Bioorthogonal (Poly)Catalyst-Linked Immunosorbent Assay for Living Cell Membrane Antigens.

Immunoassay methods, notably enzyme-linked immunosorbent assays (ELISAs), renowned for their signal amplification capabilities, are extensively employed in scientific research and clinical diagnostics. However, the instability of enzymes and their sensitivity to cellular environments present significant challenges for the broad application of ELISA in living cells. In this work, we present a bioorthogonal (poly)catalysis-linked immunosorbent assay (BCLISA) designed for the detection of cell membrane antigens, which involves coupling bioorthogonal catalysts based on small molecules or polymers to antibodies.

Description of two new species of the genus L. Koch, 1872 and the male of Jin, Yin & Zhang, 2017 from China (Araneae, Trachelidae).

Two new spider species of the genus L. Koch, 1872 are described from China: (♀) and (♀). The male of Jin, Yin & Zhang, 2017 is described for the first time.

Risk factors for postoperative delirium in adult patients undergoing cardiopulmonary bypass in cardiac surgery.

Objective: To identify risk factors for postoperative delirium in adult patients undergoing cardiopulmonary bypass.

Methods: The medical records of 214 patients who underwent cardiopulmonary bypass at the First Affiliated Hospital of Hunan Normal University from January 2022 to January 2024 were retrospectively analyzed. Based on the occurrence of postoperative delirium, patients were divided into a delirium group (49 cases) and a non-delirium group (165 cases).

A logic-activated nanoswitch for killing cancer cells according to assessment of drug-resistance.

A logic-activated nanoswitch that could diagnose the differences between drug-resistant and non-drug-resistant cancer cells and control the release of drugs was developed for enhanced chemo-gene therapy using a standalone system. Compared to traditional treatments, the nanoswitch displayed improved anti-tumor efficiency .

Clinical utility of multi-row spiral CT in diagnosing hepatic nodular lesions, gastric cancer, and Crohn's disease: a comprehensive meta-analysis.

A retrieval of relevant literature on hepatic nodular lesions, gastric cancer (GC), and Crohn's disease (CD) was conducted from Chinese and English databases. Meta-analysis was performed using Review Manager 5.4 software and the MIDAS package in Stata 18.

Three new ramarioid species of (Gomphaceae, Gomphales) from China.

Three new species of from China are described: , , and . Recognition of the new species is supported by morphological and molecular evidence. Phylogenetic analyses of concatenated ITS1-5.

Four new species of the spider genus (Araneae, Mesothelae, Liphistiidae, Liphistiinae) from Myanmar.

Four new species of belonging to the species group are described from Myanmar based on both sexes: Zhan & Xu, (♂♀), Zhan & Xu, (♂♀), Zhan & Xu, (♂♀) and Zhan & Xu, (♂♀). Currently, Myanmar stands as the westernmost country where is distributed, with the new species being found in the westernmost region of Myanmar.

[Effect of Tianma Gouteng Decoction on PINK1/Parkin pathway in oxidative stress in vascular smooth muscle cell induced by AngⅡ].

This study explored the effect of Tianma Gouteng Decoction on oxidative stress induced by angiotensin Ⅱ(AngⅡ) in vascular smooth muscle cell(VSMC) and its molecular mechanism. Primary rat VSMC were cultured using tissue block method, and VSMC were identified by α-actin immunofluorescence staining. AngⅡ at a concentration of 1×10~(-6) mol·L~(-1) was used as the stimulating factor, and Sprague Dawley(SD) rats were orally administered with Tianma Gouteng Decoction to prepare drug serum.

The unprecedented strong paratropic ring current of a bis-Pd complex of 5,10,23-trimesityl [28]heptaphyrin(1.1.0.0.1.0.0).

Acid-catalyzed Friedel-Crafts-type cyclization of tetrapyrrolic BF complex 1 and α,α'-dibromotripyrrin 2 gave 5,10,23-trimesityl [28]heptaphyrin(1.1.0.

[Effect of chronic periodontitis on quality of life and severity in patients with bronchiectasis].

Purpose: To investigate the effects of chronic periodontitis on the quality of life and severity of the disease in patients with bronchiectasis.

Methods: A total of 80 bronchiectasis patients admitted to The Fourth Hospital of Changsha between April 2021 and April 2023 were randomly selected. Patients were divided into two groups according to whether they had moderate to severe chronic periodontitis: bronchiectasis with periodontitis group (n=45) and bronchiectasis without periodontitis group (n=35).

Very severe oligozoospermia with AZFc microdeletion patients may affect intracytoplasmic sperm injection clinical outcomes: A propensity score matching analysis.

Purpose: To explore whether spermatozoa from AZFc microdeletion patients affect their outcomes of intracytoplasmic sperm injection (ICSI).

Methods: Eighty-five patients with AZFc microdeletion were recruited. A control group of one hundred and forty patients with severe oligozoospermia but without AZF microdeletion was selected using propensity score matching analysis with a 1:2 nearest neighbor algorithm ratio.

Synthesis of Ni porphyrin-Ni 5,15-diazaporphyrin hybrid tapes.

Ni porphyrin (P) and Ni 5,15-diazaporphyrin (DAP) hybrid tapes were synthesized by Suzuki-Miyaura cross-coupling reactions of - or β-borylated P with β-brominated DAP followed by intramolecular oxidative fusion reactions. -β doubly linked hybrid tapes were synthesized by oxidation of singly linked precursors with DDQ-FeCl. Synthesis of triply linked hybrid tapes was achieved by oxidation with DDQ-FeCl-AgOTf with suppression of peripheral β-chlorination.

LncRNA /IGFBP3 axis is involved in liver fibrosis by promoting the proliferation and activation of mouse hepatic stellate cells.

Liver fibrosis is a persistent damage repair response triggered by various injury factors, which leads to an abnormal accumulation of extracellular matrix within liver tissue samples. The current clinical treatment of liver fibrosis is currently ineffective; therefore, elucidating the mechanism of liver fibrogenesis is of significant importance. Herein, the function and related mechanisms of lncRNA within hepatic fibrosis were investigated.