Enhancing Ω Phase Thermal Stability in Al Alloys through Interstitial Ordering.

Scandium (Sc) can orderly occupy interstitial sites within the Ω phase of aluminum alloys, forming a new phase that significantly enhances the thermal stability of the alloy. However, Sc is relatively expensive and rare. In this work, we employ first-principles calculations to delve into the physical essence interstitial ordering of Sc in enhancing thermal stability at the electronic level, thereby revealing the crucial factors responsible for this improvement.

AP2M1 as the potential biomarker for prediction of the response of atopic dermatitis to Dupilumab therapy: Multi-omics analysis and evidence.

Many atopic dermatitis (AD) patients have suboptimal responses to Dupilumab therapy. This study identified key genes linked to this resistance using multi-omics approaches to benefit more patients. We selected a prospective cohort of 54 AD treated with Dupilumab from the GEO database.

Ambient-pressure selective hydrogenation of unsaturated aldehydes and ketones into unsaturated alcohols in the water phase.

A universal and green catalytic system for the hydrogenation of unsaturated aldehydes and ketones into the corresponding alcohols with the CC bonds retained under atmospheric hydrogen pressure in the water phase was realized by -functionalized amino ligand-stabilized ruthenium complexes (-PPhCHNHMe)[(CHNHR)]RuCl (R = H, Me, Et) and (-PPhCHNMe)[(CHNHEt)]RuCl with wide substrate compatibility and excellent functionality tolerance. The structural synergism between -PPhCHNHMe and (CHNHEt) achieves the enhanced performance, with a positive correlation with the electron density of the amino ligand.

Retraction: Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.

[This retracts the article DOI: 10.21037/atm-22-5443.].

Comparison of various liver cancer staging systems in predicting prognosis after initial transcatheter arterial chemoembolization: a retrospective study from China.

Background: Hepatocellular carcinoma (HCC) constitutes approximately 75-85% of primary liver cancers and is a heavy burden on public health. Many innovative prediction systems have integrated radiomics, artificial intelligence, pathological information, or even genetic information for the stratification and prognosis prediction of patients with HCC. However, these systems still lack practical and clinical applications.

Exploration of Body Image in Postoperative Patients With Oral Cancer: An Exploratory Sequential Mixed Methods Study.

Background: Postoperative patients with oral cancer are deeply distressed about their body image. However, their true inner feelings and the factors influencing body image remain unclear.

Aims: This study aims to investigate the experience of body image disturbance in patients 3 months after oral cancer surgery and analyze the influencing factors.

Static and dynamic connectivity structure of white-matter functional networks across the adult lifespan.

Aging of the human brain involves intricate biological processes, resulting in complex changes in structure and function. While the effects of aging on gray matter (GM) connectivity are extensively studied, white matter (WM) functional changes have received comparatively less attention. This study examines age-related WM functional dynamics using resting-state fMRI across the adult lifespan.

Neoadjuvant chemoimmunotherapy for locally advanced squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.

Background: Neoadjuvant chemoimmunotherapy emerged as a promising treatment for locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, a comparison of clinical outcomes with neoadjuvant chemotherapy was lacking.

Objective: To provide evidence supporting clinical decision-making for neoadjuvant chemoimmunotherapy in LA-SCCHN treatment.

Enhancing Ω Phase Thermal Stability in Al Alloys through Interstitial Ordering.

Scandium (Sc) can orderly occupy interstitial sites within the Ω phase of aluminum alloys, forming a new phase that significantly enhances the thermal stability of the alloy. However, Sc is relatively expensive and rare. In this work, we employ first-principles calculations to delve into the physical essence interstitial ordering of Sc in enhancing thermal stability at the electronic level, thereby revealing the crucial factors responsible for this improvement.

LncRNA FGD5-AS1 Facilitates Hepatocellular Carcinoma Cell Stemness by Enhancing PKD1 mRNA Stability Through Binding With MSI2.

Hepatocellular carcinoma (HCC) is a major global health concern that accounts for more than 80% of all primary hepatic carcinomas. The long noncoding RNA FGD5 antisense RNA 1 (FGD5-AS1) has been linked to HCC cell stemness and proliferation. However, the exact function of FGD5-AS1 in HCC remains unclear.

Development and verification of prognostic nomogram for extraskeletal Ewing's sarcoma based on the SEER database.

Background: Extraskeletal Ewing's sarcoma (EES) is a rare tumor, and there is currently no predictive model for overall survival of EES patients. This study sought to use data from the Surveillance, Epidemiology, and End Results (SEER) database to develop a clinical predictive model that could be used to assess the prognosis of EES patients.

Methods: We selected and downloaded prognostic data on 356 patients diagnosed with extraskeletal Ewing's sarcoma based on screening criteria, These patients were distributed between 2004 and 2015.

The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study.

Background: While previous studies have explored the associations and causalities among platelet count (PC), mean platelet volume (MPV), and erectile dysfunction (ED), further investigations are needed to clarify these relationships using advanced methodologies and analyzing specific populations.

Aim: To investigate the associations and causalities among PC, MPV, and ED using observational study and Mendelian randomization (MR) analysis.

Methods: A total of 114 patients with ED and 158 healthy control participants underwent a fasting blood draw to test for PC and MPV along with a comprehensive laboratory examination.

Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024.

Background: Prostate cancer (PCa) ranks as the second most common disease among men and the fourth most prevalent cancer worldwide. Enhanced glycolysis and excessive lactate secretion are recognized as critical factors driving the progression of various cancers. This study systematically investigated the research trends associated with glycolysis in PCa through bibliometric analysis.

Elucidating the roles of voltage sensors in Na1.9 activation and inactivation through a spider toxin.

The gating process of voltage-gated sodium (Na) channels is extraordinary intrinsic and involves numerous factors, such as voltage-sensing domain (VSD), the N-terminus and C-terminus, and the auxiliary subunits. To date, the gating mechanism of Na channel has not been clearly elucidated. Na1.

Fear of progression in Chinese patients after cardiac valve replacement: profiles, influencing factors, and mechanisms.

Aims: This study aims to investigate the latent profiles and influencing factors of fear of progression (FoP) among patients following cardiac valve replacement (CVR) and to explore the mechanisms of FoP and its primary influencing factors.

Methods And Results: This cross-sectional study included 385 patients who had undergone CVR in Hunan Province, China. Data on FoP, Type D personality, death anxiety, medical coping modes, and family function were collected using appropriate questionnaires.

Multifunctional porphyrinic metal-organic framework-based nanoplatform regulating reactive oxygen species achieves efficient imaging-guided cascaded nanocatalytic therapy.

The integration of reactive oxygen species (ROS) related photodynamic therapy (PDT) with the strategy of reshaping the tumor microenvironment (TME) has emerged as a potential approach for nanodiagnostic and therapeutic interventions. However, the therapeutic efficacy based on ROS treatments may be hindered by intracellular antioxidants such as glutathione (GSH) and tumor hypoxia. To address these challenges, a nanoplatform based on GSH-responsive multifunctional porphyrinic metal-organic framework (PCN-224@Au@MnO@HA, PAMH) was proposed.

Diagnosis of Autism Spectrum Disorder (ASD) by Dynamic Functional Connectivity Using GNN-LSTM.

Early detection of autism spectrum disorder (ASD) is particularly important given its insidious qualities and the high cost of the diagnostic process. Currently, static functional connectivity studies have achieved significant results in the field of ASD detection. However, with the deepening of clinical research, more and more evidence suggests that dynamic functional connectivity analysis can more comprehensively reveal the complex and variable characteristics of brain networks and their underlying mechanisms, thus providing more solid scientific support for computer-aided diagnosis of ASD.

Expanding the Potential of Circular RNA (CircRNA) Vaccines: A Promising Therapeutic Approach.

In recent years, circular RNAs (circRNAs) have garnered significant attention due to their unique structure and function, positioning them as promising candidates for next-generation vaccines. The circRNA vaccine, as an RNA vaccine, offers significant advantages in preventing infectious diseases by serving as a vector for protein expression through non-canonical translation. Notably, circRNA vaccines have demonstrated enduring antigenic expression and generate a larger percentage of neutralizing antibodies compared to mRNA vaccines administered at the same dosage.

An Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments.

Myopia is one of the dominant causes of visual impairment in the world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that myopia could be caused by both environmental and genetic risk factors.

Receptor-like Kinase GOM1 Regulates Glume-Opening in Rice.

Glume-opening of thermosensitive genic male sterile (TGMS) rice ( L.) lines after anthesis is a serious problem that significantly reduces the yield and quality of hybrid seeds. However, the molecular mechanisms regulating the opening and closing of rice glumes remain largely unclear.

Comparative impact of exercise variants on depressive symptoms in cancer patients: A systematic review and network meta-analysis.

Purpose: The aim of this study was to conduct a network meta-analysis to assess the effectiveness of various forms of exercise as an intervention for post-cancer depression and to provide a guiding program based on evidence-based medicine for subsequent clinical practice.

Methods: This review was registered on the PROSPERO website with ID CRD42023485407. Pubmed, Embase, Cochrane Library, and Web of Science were comprehensively searched to obtain published articles from the establishment of the database until October 7, 2023.

Near-infrared fluorogenic RNA for in vivo imaging and sensing.

Fluorogenic RNA aptamers have various applications, including use as fluorescent tags for imaging RNA trafficking and as indicators of RNA-based sensors that exhibit fluorescence upon binding small-molecule fluorophores in living cells. Current fluorogenic RNA:fluorophore complexes typically emit visible fluorescence. However, it is challenging to develop fluorogenic RNA with near-infrared (NIR) fluorescence for in vivo imaging and sensing studies.

Analysis of influencing factors of narrative medicine competence in the clinical nursing population in Hunan province, China: a cross-sectional study.

Objective: To explore the current status of clinical nurses' narrative medicine (NM) ability and its related influencing factors, so as to provide a theoretical basis for nursing managers to develop targeted nurse training programmes.

Design: A cross-sectional study.

Setting: A total of 1792 clinical nurses from eight medical institutions in Hunan province were selected as participants using convenience sampling.